Perioperative methylprednisolone and outcome in neonates undergoing heart surgery

Pediatrics

Volumn 129, Issue 2, 2012, Pages

  Pasquali, Sara K ^a,b   Li, Jennifer S ^a,b   He, Xia ^b   Jacobs, Marshall L ^c   O'Brien, Sean M ^a,b   Hall, Matthew ^d   Jaquiss, Robert D B ^a   Welke, Karl F ^e   Peterson, Eric D ^a,b   Shah, Samir S ^f   Gaynor, J William ^g   Jacobs, Jeffrey P ^h,i  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Child Health Corporation of America   (United States)

^e SEATTLE CHILDREN S HOSPITAL   (United States)

^f CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h UNIVERSITY OF SOUTH FLORIDA   (United States)

ⁱ JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

Author keywords

Congenital heart disease; Heart surgery; Outcomes

Indexed keywords

METHYLPREDNISOLONE;

ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; FEMALE; HEART SURGERY; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN MORTALITY; OBSERVATIONAL STUDY; PERIOPERATIVE PERIOD; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROGNOSIS; SURGICAL RISK;

EID: 84863048754     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2011-2034     Document Type: Article

References (20)

1. Checchia PA, Bronicki RA, Costello JM, Nelson DP. Steroid use before pediatric cardiac operations using cardiopulmonary bypass: an international survey of 36 centers. Pediatr Crit Care Med. 2005;6(4):441-444 (Pubitemid 40980824)
2. Lindberg L, Forsell C, Jögi P, Olsson AK. Effects of dexamethasone on clinical course, C-reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery. Br J Anaesth. 2003;90(6):728-732 (Pubitemid 36700774)
3. Bronicki RA, Backer CL, Baden HP, Mavroudis C, Crawford SE, Green TP. Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children. Ann Thorac Surg. 2000;69(5):1490-1495 (Pubitemid 30434881)
4. Clarizia NA, Manlhiot C, Schwartz SM, et al. Improved outcomes associated with intraoperative steroid use in high-risk pediatric cardiac surgery. Ann Thorac Surg. 2011;91(4):1222-1227
5. Robertson-Malt S, Afrane B, El Barbary M. Prophylactic steroids for pediatric open heart surgery. Cochrane Database Syst Rev. 2007;(4)CD005550
6. Pasquali SK, Hall M, Li JS, et al. Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database. Circulation. 2010;122(21):2123-2130
7. Lodge AJ, Chai PJ, Daggett CW, Ungerleider RM, Jaggers J. Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: timing of dose is important. J Thorac Cardiovasc Surg. 1999;117(3):515-522 (Pubitemid 29117532)
8. Graham EM, Atz AM, Butts RJ, et al. Standardized preoperative corticosteroid treatment in neonates undergoing cardiac surgery: results from a randomized trial [published online ahead of print May 19, 2011]. J Thorac Cardiovasc Surg. doi:10.1016/j.jtcvs.2011.04.019
9. Pasquali SK, Jacobs JP, Shook GJ, et al. Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population. Am Heart J. 2010;160(6):1099-1104
10. Pasquali SK, Li JS, He X, et al. Comparative analysis of antifibrinolytic medications in pediatric heart surgery. J Thorac Cardiovasc Surg. 2011, In press
11. Franklin RC, Jacobs JP, Krogmann ON, et al. Nomenclature for congenital and paediatric cardiac disease: historical perspectives and The International Pediatric and Congenital Cardiac Code. Cardiol Young. 2008;18(suppl 2):70-80
12. Clarke DR, Breen LS, Jacobs ML, et al. Verification of data in congenital cardiac surgery. Cardiol Young. 2008;18(suppl 2):177-187
13. Johnson JN, Jaggers J, Li S, et al. Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2010;139(5):1205-1210
14. O'Brien SM, Clarke DR, Jacobs JP, et al. An empirically based tool for analyzing mortality associated with congenital heart surgery. J Thorac Cardiovasc Surg. 2009;138(5):1139-1153
15. Congenital Database Full Specifications STS. Available at: www.sts.org/documents/pdf/Congenital-DataSpecs-250.pdf. Accessed June 1, 2011
16. Casey LC. Role of cytokines in the pathogenesis of cardiopulmonary- induced multisystem organ failure. Ann Thorac Surg. 1993;56(suppl 5):S92-S96 (Pubitemid 23328711)
17. Boyle EM, Jr;Pohlman TH, Johnson MC, Verrier ED. Endothelial cell injury in cardiovascular surgery: the systemic inflammatory response. Ann Thorac Surg. 1997;63(1):277-284 (Pubitemid 27039090)
18. Shum-Tim D, Tchervenkov CI, Laliberté E, et al. Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest: minimal protection of pump prime methylprednisolone. Eur J Cardiothorac Surg. 2003;24(1):125-132 (Pubitemid 36802351)
19. Jansen NJG, van Oeveren W, van Vliet M, Stoutenbeek CP, Eysman L, Wildevuur CRH. The role of different types of corticosteroids on the inflammatory mediators in cardiopulmonary bypass. Eur J Cardiothorac Surg. 1991;5(4):211-217
20. Li JS, Cohen-Wolkowiez M, Pasquali SK. Pediatric cardiovascular drug trials, lessons learned. J Cardiovasc Pharmacol. 2011;58(1):4-8