The pharmacokinetics of inhaled morphine delivered by an ultrasonic nebulizer in ventilated dogs

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 25, Issue 1, 2012, Pages 41-46

  Xu, Xin ^a   Wang, Xiaohai ^a   Ge, Weihong ^a   Pan, Lin ^a   Zheng, Man ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Inhaled; Mechanical ventilation; Morphine; Nebulized; Pharmacokinetic; Ultrasonic

Indexed keywords

MORPHINE;

ARTERIAL BLOOD; ARTICLE; BIOAVAILABILITY; CHINA; CONTROLLED STUDY; DOG; DRUG ABSORPTION; FEMALE; MALE; NEBULIZER; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; ULTRASOUND;

ADMINISTRATION, INHALATION; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; FEMALE; MALE; MORPHINE; NEBULIZERS AND VAPORIZERS; ULTRASONICS;

EID: 84863045854     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2010.0858     Document Type: Article

References (16)

1. Thipphawong J, Babul N, Morishige R, Morishige RJ, Findlay HK, Reber KR, Millward GJ, and Otulana BA: Analgesic efficacy of inhaled morphine in patients after bunionectomy surgery. Anesthesiology. 2003;99: 693-700. (Pubitemid 37051986)
2. Fulda GJ, Giberson F, and Fagraeus L: A prospective randomized trial of nebulized morphine compared with patient-controlled analgesia morphine in the management of acute thoracic pain. J Trauma. 2005;59:383-388.
3. Slatkin N, Rauck R, Koczwara B, Chevlen E, Thipphawong J, Morishige R, Otulana B, Beckman R, and Gonda I: Analgesic efficacy of inhaled morphine delivered with the AERXTMmPMS for breakthrough cancer pain. J Pain 2002; 3(Suppl.1):43.
4. Onal SA, Kelesx E, Toprak GC, Demirel I, Alpay HC, and Avci L: Preliminary findings for preemptive analgesia with inhaled morphine: Efficacy in septoplasty and septorhinoplasty cases. Otolaryngol Head Neck Surg. 2006;135: 85-89. (Pubitemid 43946548)
5. Samir KB, Eugene RV, and Kenneth RE: Management of acute chest wall sickle cell pain with nebulized morphine. Am J Hematol. 2004;76:190-191.
6. Chrubasik J, Wüst H, Friedrich G, and Geller E: Absorption and bioavailability of nebulized morphine. Br J Anaesth. 1988;61:228-230.
7. Ward ME, Woodhouse A, Mather LE, Farr SJ, Okikawa JK, Lloyd P, Schuster JA, and Rubsamen RM: Morphine pharmacokinetics after pulmonary administration from a novel aerosol delivery system. Clin Pharmacol Ther. 1997;62: 596-609. (Pubitemid 28068063)
8. Masood AR, and Thomas SH: Systemic absorption of nebulized morphine compared with oral morphine in healthy subjects. Br J Clin Pharmacol. 1996;41:250-252. (Pubitemid 26079186)
9. Dershwitz M, Walsh JL, Morishige RJ, Connors PM, Rubsamen RM, Shafer SL, and Rosow CE: Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers. Anesthesiology. 2000;93: 619-628.
10. Fok TF, Al-Essa M, Monkman S, Dolovich M, Girard L, Coates G, and Kirpalani H: Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler, jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits. Pediatr Res. 1997;42:721-727. (Pubitemid 27459484)
11. Köhler E, Sollich V, Schuster-Wonka R, and Hühnerbein J: Lung deposition in cystic fibrosis patients using an ultrasonic or a jet nebulizer. J Aerosol Med. 2003;16:37-46. (Pubitemid 36457652)
12. Dhand R: Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv. 2008;21:45-60.
13. MacLoughlin RJ, Higgins BD, Laffey JG, and O'Brien T: Optimized aerosol delivery to a mechanically ventilated rodent. J Aerosol Med Pulm Drug Deliv. 2009;22:323-332.
14. Khatri L, Taylor KM, Craig DQ, and Palin K: An assessment of jet and ultrasonic nebulisers for the delivery of lactate dehydrogenase solutions. Int J Pharmacol. 2001;227:121-131. (Pubitemid 32868765)
15. Xu X, and Wang X: Simulation analysis on nebulizing effects of supersonic atomizer adapted to ventilator. Inform Medical Equip. 2007;22:11-13.
16. Xu X, Xu J, and Wang X: Morphine nebulized by supersound atomizer for postoperative pain relieve in gynaecologic and obstetric patients. Chin J Postgrad Med. 2008, 31:21-24.