Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice

Bioscience Reports

Volumn 32, Issue 2, 2012, Pages 185-195

  Huang, Hui ^a   Xin, Hong ^a   Liu, Xinhua ^a   Xu, Yajun ^a   Wen, Danyi ^a   Zhang, Yahua ^a   Zhu, Yi Zhun ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Anti inflammatory; Db db mice; Nuclear factor B (NF B); SCM 198; Tumour necrosis factor (TNF ); Type 2 diabetes

Indexed keywords

GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEONURINE; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PIOGLITAZONE; PROTEIN KINASE B; SCM 198; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG SCREENING; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORAL GLUCOSE TOLERANCE TEST; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION REGULATION; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; GALLIC ACID; HYPOGLYCEMIC AGENTS; INFLAMMATION MEDIATORS; LEONURUS; LIVER; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B;

MUS;

EID: 84863037209     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20110017     Document Type: Article

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