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Volumn 27, Issue 3, 2012, Pages 628-636

A study of the suppressive effect on human pancreatic adenocarcinoma cell proliferation and angiogenesis by stable plasmid-based siRNA silencing of c-Src gene expression

Author keywords

Angiogenesis; c Src; Pancreatic cancer; Proliferation; siRNA

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CD34 ANTIGEN; GEMCITABINE; GREEN FLUORESCENT PROTEIN; LIPOFECTAMINE; MESSENGER RNA; PLASMID VECTOR; PROTEIN KINASE P60; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; VASCULOTROPIN;

EID: 84863031064     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/oror.2011.1602     Document Type: Article
Times cited : (8)

References (31)
  • 1
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M: Pancreatic cancer. N Engl J Med 362: 1605-1617, 2010.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 2
    • 0016429845 scopus 로고
    • Tumor angiogenesis: A possible control point in tumor growth
    • Folkman J: Tumor angiogenesis: a possible control point in tumor growth. Ann Intern Med 82: 96-100, 1975.
    • (1975) Ann Intern Med , vol.82 , pp. 96-100
    • Folkman, J.1
  • 3
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS: Tumor angiogenesis. New Engl J Med 358: 2039-2049, 2008.
    • (2008) New Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 4
    • 35348855682 scopus 로고    scopus 로고
    • VEGF: An essential mediator of both angiogenesis and endochondral ossification
    • Dai J and Rabie A: VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res 86: 937-950, 2007.
    • (2007) J Dent Res , vol.86 , pp. 937-950
    • Dai, J.1    Rabie, A.2
  • 5
    • 24744466384 scopus 로고    scopus 로고
    • Bevacizumab - Current status and future directions
    • DOI 10.1093/annonc/mdi208
    • Midgley R, Kerr D: Bevacizumab - current status and future directions. Ann Oncol 16: 999-1004, 2005. (Pubitemid 41418303)
    • (2005) Annals of Oncology , vol.16 , Issue.7 , pp. 999-1004
    • Midgley, R.1    Kerr, D.2
  • 7
    • 51349141767 scopus 로고    scopus 로고
    • Inhibition growth by adenovirus-mediated human Interleukin-24 expression in animal model
    • Pan X, Sheng WH, Zhu QY, et al: Inhibition growth by adenovirus-mediated human Interleukin-24 expression in animal model. Cancer Biother Radio 23: 425-434, 2008.
    • (2008) Cancer Biother Radio , vol.23 , pp. 425-434
    • Pan, X.1    Sheng, W.H.2    Zhu, Q.Y.3
  • 8
    • 77950843538 scopus 로고    scopus 로고
    • The dicey role dicer: Implications for RNAi therapy
    • Merritt WM, Bar-Eli M and Sood AK: The dicey role dicer: implications for RNAi therapy. Cancer Res 70: 2571-2574, 2010.
    • (2010) Cancer Res , vol.70 , pp. 2571-2574
    • Merritt, W.M.1    Bar-Eli, M.2    Sood, A.K.3
  • 10
    • 84863080113 scopus 로고    scopus 로고
    • Pathways for aberrant angiogenesis in cancer
    • Korc M: Pathways for aberrant angiogenesis in cancer. Mol Cancer 2: 1-8, 2003.
    • (2003) Mol Cancer , vol.2 , pp. 1-8
    • Korc, M.1
  • 11
    • 0035553274 scopus 로고    scopus 로고
    • Pancreatic Cancer: Factors Regulating Tumor Development, Maintenance and Metastasis
    • DOI 10.1159/000055854
    • Shi X, Friess H, Kleeff J, et al: Pancreatic cancer: factors regulating tumor development, maintenance and metastasis. Pancreatology 1: 517-524, 2001. (Pubitemid 33681754)
    • (2001) Pancreatology , vol.1 , Issue.5 , pp. 517-524
    • Shi, X.1    Friess, H.2    Kleeff, J.3    Ozawa, F.4    Buchler, M.W.5
  • 12
    • 2942536487 scopus 로고    scopus 로고
    • Invasion and metastasis in pancreatic cancer
    • Keleg S, Buchler P, Ludwig R, et al: Invasion and metastasis in pancreatic cancer. Mol Cancer 2: 14-20, 2003.
    • (2003) Mol Cancer , vol.2 , pp. 14-20
    • Keleg, S.1    Buchler, P.2    Ludwig, R.3
  • 13
    • 4444366400 scopus 로고    scopus 로고
    • Molecular therapy in pancreatic adenocarcinonoma
    • MacKenzie MJ: Molecular therapy in pancreatic adenocarcinonoma. Lancet Oncol 5: 541-549, 2004.
    • (2004) Lancet Oncol , vol.5 , pp. 541-549
    • MacKenzie, M.J.1
  • 15
    • 33646550512 scopus 로고    scopus 로고
    • Molecular biomarkers: Their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer
    • DOI 10.1158/1535-7163.MCT-06-0005
    • Jimeno A and Hidalgo M: Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. Mol Cancer Ther 5: 787-796, 2006. (Pubitemid 43724577)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.4 , pp. 787-796
    • Jimeno, A.1    Hidalgo, M.2
  • 16
    • 0037150728 scopus 로고    scopus 로고
    • Src in cancer: Deregulation and consequences for cell behaviour
    • Frame CM: Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 1602: 114-130, 2002.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 114-130
    • Frame, C.M.1
  • 17
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM and Brugge JS: Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513-607, 1997.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-607
    • Thomas, S.M.1    Brugge, J.S.2
  • 18
    • 0038386613 scopus 로고    scopus 로고
    • Src family kinases in tumor progression and metastasis
    • DOI 10.1023/A:1023772912750
    • Summy JM and Gallick GE: Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 22: 337-358, 2003. (Pubitemid 36791891)
    • (2003) Cancer and Metastasis Reviews , vol.22 , Issue.4 , pp. 337-358
    • Summy, J.M.1    Gallick, G.E.2
  • 19
    • 4344610825 scopus 로고    scopus 로고
    • Src family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells
    • DOI 10.1158/0008-5472.CAN-04-0504
    • Zhang Q, Thomas SM, Xi S, et al: Src family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res 64: 6166-6173, 2004. (Pubitemid 39129418)
    • (2004) Cancer Research , vol.64 , Issue.17 , pp. 6166-6173
    • Zhang, Q.1    Thomas, S.M.2    Xi, S.3    Smithgall, T.E.4    Siegfried, J.M.5    Kamens, J.6    Gooding, W.E.7    Grandis, J.R.8
  • 21
    • 13944282937 scopus 로고    scopus 로고
    • Identification of Src-specific phosphorylation site on focal adhesion kinase: Dissection the role Src SH2 and catalytic functions and their consequences for tumor cell behaviour
    • Brunton VG, Avizienyte E, Fincham VJ, et al: Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection the role Src SH2 and catalytic functions and their consequences for tumor cell behaviour. Cancer Res 65: 1335-1345, 2005.
    • (2005) Cancer Res , vol.65 , pp. 1335-1345
    • Brunton, V.G.1    Avizienyte, E.2    Fincham, V.J.3
  • 23
    • 0034603197 scopus 로고    scopus 로고
    • New roles for Src kinases in control of cell survival and angiogenesis
    • Schlessinger J: New roles for Src kinases in control of cell survival and angiogenesis. Cell 100: 293-296, 2000.
    • (2000) Cell , vol.100 , pp. 293-296
    • Schlessinger, J.1
  • 24
    • 85047696594 scopus 로고    scopus 로고
    • Src kinase contributes to the metastatic spread of carcinoma cells
    • DOI 10.1038/sj/onc/1205298
    • Boyer B, Bourgeois Y and Poupon MF: Src kinase contributes to metastatic spread of cells. Oncogene 21: 2347-2356, 2002. (Pubitemid 34407294)
    • (2002) Oncogene , vol.21 , Issue.15 , pp. 2347-2356
    • Boyer, B.1    Bourgeois, Y.2    Poupon, M.-F.3
  • 27
    • 2942607458 scopus 로고    scopus 로고
    • siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity
    • DOI 10.1016/j.jamcollsurg.2004.01.037, PII S1072751504001978
    • Duxbury MS, Ito H, Zinner MJ, et al: siRNA directed against c-Src enhances pancreatic adenocarcinoma cell gemcitabine chemosensitivity. J Am Coll Surg 198: 953-959, 2004. (Pubitemid 38759847)
    • (2004) Journal of the American College of Surgeons , vol.198 , Issue.6 , pp. 953-959
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 28
    • 72949121716 scopus 로고    scopus 로고
    • Regulation endometrial vascular remodelling: Role of the vascular endothelial growth factor family and the angiopoietin-TIE signaling system
    • Girling JE and Rogers PAW: Regulation endometrial vascular remodelling: role of the vascular endothelial growth factor family and the angiopoietin-TIE signaling system. Reproduction 138: 883-893, 2009.
    • (2009) Reproduction , vol.138 , pp. 883-893
    • Girling, J.E.1    Rogers, P.A.W.2
  • 29
    • 34548798765 scopus 로고    scopus 로고
    • Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoietin-2
    • DOI 10.1158/0008-5472.CAN-07-1684
    • Lewis CE, De Palma M and Naldini L: Tie2 expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res 67: 8429-8432, 2007. (Pubitemid 47437413)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8429-8432
    • Lewis, C.E.1    De Palma, M.2    Naldini, L.3
  • 30
    • 0030028585 scopus 로고    scopus 로고
    • CD34: Structure, biology, and clinical utility
    • Krause DS, Fackler MJ, Civin CI, et al: CD34: structure, biology, and clinical utility. Blood 87: 1-13, 1996. (Pubitemid 26018389)
    • (1996) Blood , vol.87 , Issue.1 , pp. 1-13
    • Krause, D.S.1    Fackler, M.J.2    Civin, C.I.3    May, W.S.4
  • 31
    • 59549100452 scopus 로고    scopus 로고
    • Novel functions of the CD34 family
    • Nielsen JS and McNagny KM: Novel functions of the CD34 family. J Cell Sci 121: 3683-3692, 2008.
    • (2008) J Cell Sci , vol.121 , pp. 3683-3692
    • Nielsen, J.S.1    McNagny, K.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.