Prunella vulgaris suppresses HG-induced vascular inflammation via Nrf2/HO-1/eNOS activation

International Journal of Molecular Sciences

Volumn 13, Issue 1, 2012, Pages 1258-1268

  Hwang, Sun Mi ^a,b   Lee, Yun Jung ^a,c   Yoon, Jung Joo ^a,c   Lee, So Min ^a,c   Kim, Jin Sook ^d   Kang, Dae Gill ^a,c   Lee, Ho Sub ^a,c  

^a Wonkwang University   (South Korea)

^b Korea Research Institute of Standards and Science   (South Korea)

^c Wonkwang University   (South Korea)

^d Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Atherosclerosis; ENOS; Inflammation; NF b; Nrf2; Prunella vulgaris

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; NUCLEAR FACTOR E2 RELATED FACTOR 2; PROTEIN KINASE B; PRUNELLA VULGARIS EXTRACT; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; GLUCOSE; NOS3 PROTEIN, HUMAN; PLANT EXTRACT; TRANSCRIPTION FACTOR NRF2;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULITIS; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; HL 60 CELL LINE; INFLAMMATION; METABOLISM; PHOSPHORYLATION; PRUNELLA; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

PRUNELLA VULGARIS;

CELL ADHESION; CELLS, CULTURED; GELATINASES; GLUCOSE; HEME OXYGENASE-1; HL-60 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; NF-E2-RELATED FACTOR 2; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; PRUNELLA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84863027681     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13011258     Document Type: Article

References (19)

1. Ding, H.; Hashem, M.; Wiehler, W.B.; Lau, W.; Martin, J.; Reid, J.; Triggle, C. Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse. Br. J. Pharmacol. 2005, 146, 1110-1118.
2. Quagliaro, L.; Piconi, L.; Assaloni, R.; Da Ros, R.; Maier, A.; Zuodar, G.; Ceriello, A. Intermittent HG enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: The distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005, 183, 259-267.
3. Shanmugam, N.; Reddy, M.A.; Guha, M.; Natarajan, R. HG-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 2003, 52, 1256-1264.
4. Adya, R.; Tan, B.K.; Chen, J.; Randeva, H.S. Nuclear factor-kappaB induction by visfatin in human vascular endothelial cells: its role in MMP-2/9 production and activation. Diabetes Care 2008, 31, 758-760.
5. Itoh, K.; Wakabayashi, N.; Katoh, Y.; Ishii, T.; Igarashi, K.; Engel, J.D.; Yamamoto, M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 1999, 13, 76-86.
6. Jaiswal, A.K. Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radical Biol. Med. 2000, 29, 254-262.
7. Chen, X.L.; Dodd, G.; Thomas, S.; Zhang, X.; Wasserman, M.A.; Rovin, B.H.; Kunsch, C. Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am. J. Physiol. Heart Circ. Physiol. 2006, 290, H1862-H1870.
8. Braam, B.; Verhaar, M.C. Understanding eNOS for pharmacological modulation of endothelial function: a translational view. Curr. Pharm. Des. 2007, 13, 1727-1740.
9. Zhu, Y.-P. Chinese materia medica-chemistry, pharmacology and application. Phytochemistry 2000, 54, 111-112.
10. Lamaison, J.L.; Petitjean-Freytet, C.; Carnat, A. Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid. Pharm. Acta Helv. 1991, 66, 185-188.
11. Chen, J.W.; Chen, Y.H.; Lin, F.Y.; Chen, Y.L.; Lin, S.J. Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2003, 23, 1559-1566.
12. Rizzo, N.O.; Maloney, E.; Pham, M.; Luttrell, I.; Wessells, H.; Tateya, S.; Daum, G.; Handa, P.; Schwartz, M.W.; Kim, F. Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 758-765.
13. Lee, Y.J.; Kang, D.G.; Kim, J.S.; Lee, H.S. Effect of Buddleja officinalis on high-glucose-induced vascular inflammation in human umbilical vein endothelial cells. Exp. Biol. Med. (Maywood) 2008, 233, 694-700.
14. Surh, Y.J.; Kundu, J.K.; Li, M.H.; Na, H.K.; Cha, Y.N. Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Arch. Pharm. Res. 2009, 32, 1163-1176.
15. Heiss, E.H.; Schachner, D.; Werner, E.R.; Dirsch, V.M. Active NF-E2-related factor (Nrf2) contributes to keep endothelial NO synthase (eNOS) in the coupled state: role of reactive oxygen species (ROS), eNOS, and heme oxygenase (HO-1) levels. J. Biol. Chem. 2009, 284, 31579-31586.
16. Gong, P.; Stewart, D.; Hu, B.; Li, N.; Cook, J.; Nel, A.; Alam, J. Activation of the mouse heme oxygenase-1 gene by 15-deoxy-Delta(12,14)-prostaglandin J(2) is mediated by the stress response elements and transcription factor Nrf2. Antioxid. Redox. Signal. 2002, 4, 249-257.
17. Steinkamp-Fenske, K.; Bollinger, L.; Völler, N.; Xu, H.; Yao, Y.; Bauer, R.; Förstermann, U.; Li, H. Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Atherosclerosis 2007, 195, 104-111.
18. Pae, H.O.; Oh, G.S.; Choi, B.M.; Kim, Y.M.; Chung, H.T. A molecular cascade showing nitric oxide-heme oxygenase-1-vascular endothelial growth factor-interleukin-8 sequence in human endothelial cells. Endocrinology 2005, 146, 2229-2238.
19. Mackman, N.; Brand, K.; Edgington, T.S. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites. J. Exp. Med. 1991, 174, 1517-1526.