Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 4, 2012, Pages

  Chen, Jian Xiong ^a   Zeng, Heng ^a   Reese, Jeff ^a   Aschner, Judy L ^a   Meyrick, Barbara ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Myocardial capillary density; Type 2 diabetes; Vascular endothelial growth factor

Indexed keywords

ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; CALVASCULIN; CASPASE 3; INTERCELLULAR ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; WNT7B PROTEIN;

ADENOVIRUS; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATTENUATION; CAPILLARY DENSITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE EXACERBATION; DRUG EXPOSURE; ENZYME ACTIVITY; GENE SILENCING; HEART MUSCLE FIBROSIS; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; MYOCARDIAL ANGIOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANGIOPOIETIN-2; ANIMALS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CORONARY VESSELS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FIBROSIS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICE; MICE, MUTANT STRAINS; MYOCARDIUM; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS; RECEPTOR, TIE-2; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WNT PROTEINS;

EID: 84863026962     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00866.2011     Document Type: Article

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