Epitope peptides of influenza H3N2 virus neuraminidase gene designed by immunoinformatics

Acta Biochimica et Biophysica Sinica

Volumn 44, Issue 2, 2012, Pages 113-118

  Liang, Lijun ^a,c   Huang, Ping ^a,c   Wen, Miaoheng ^b   Ni, Hanzhong ^a   Tan, Songnuan ^b   Zhang, Yonghui ^a   Chen, Qiuxia ^a  

^a GUANGZHOU CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b Sinoasis Pharmaceuticals (Guangzhou) Inc   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

B cell epitope; H3N2; immunoinformatics; neuraminidase (NA)

Indexed keywords

EPITOPE; SIALIDASE; VIRUS ANTIBODY; VIRUS ANTIGEN;

AMINO ACID SUBSTITUTION; ANIMAL; ARTICLE; BIOLOGY; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYMOLOGY; GENETICS; HEMAGGLUTINATION INHIBITION TEST; HUMAN; IMMUNOLOGY; INFLUENZA VIRUS A H3N2; PATHOGENICITY; RABBIT; VIRUS GENE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; COMPUTATIONAL BIOLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; GENES, VIRAL; HEMAGGLUTINATION INHIBITION TESTS; HUMANS; INFLUENZA A VIRUS, H3N2 SUBTYPE; MODELS, MOLECULAR; NEURAMINIDASE; RABBITS;

ORYCTOLAGUS CUNICULUS;

EID: 84863020838     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmr101     Document Type: Article

References (19)

1. Cox NJ and Subbarao K. Global epidemiology of influenza: Past and present. Annu Rev Med 2000, 51: 407-421.
2. Suwannakarn K, Chieochansin T, Thongmee C, Makkoch J, Praianantathavorn K, Theamboonlers A and Sreevatsan S, et al. Molecular evolution of human H1N1 and H3N2 influenza A virus in Thailand, 2006-2009. PLoS One 2010, 5: E9717.
3. Huang P and Deng F. Influenza. Guangzhou: Guangdong Technological Press, 2004, 89-91.
4. Huang IC, Li W, Sui J, Marasco W, Choe H and Farzan M. Influenza A virus neuraminidase limits viral superinfection. J Virol 2008, 82: 4834-4843.
5. Huang P, Xu Y, Ni H, Zhong J, Zhang X, Tan S and Wu D, et al. Linear B-cell epitope mapping of neuraminidases of the H1N1 viruses based on immunoinformatics. Vaccine 2011, 29: 1278-1282.
6. Huang P, Yu S and Ke C. Stepwise prediction and statistical screening: The B-cell epitopes on neuraminidase of human avian H5N1 virus. Chin Sci Bull 2008, 53: 3642-3647.
7. Tomar N and De RK. Immunoinformatics: An integrated scenario. Immunology 2010, 31: 153-168.
8. Huang P, Xu YS, Zhong J, Ni HZ, Zhang YH, Chen QX and Tan SN, et al. Characterization of epitope peptides of neuraminidases of the 2009 A H1N1 viruses designed by immunoinformatics. Prog Biochem Biophys 2011, 38: 929-935.
9. Arnold K, Bordoli L, Kopp J and Schwede T. The SWISS-MODEL Workspace: A web-based environment for protein structure homology modeling. Bioinformatics 2006, 22: 195-201.
10. Krieger E, Koraimann G and Vriend G. Increasing the precision of comparative models with YASARA NOVA: A self-parametrizing force field. Proteins 2002, 47: 393-402.
11. Qin H, Jin X, Huang W and Liu Y. Production of an anti-idiotypic antibody single chain variable fragment vaccine against Edwardsiella tarda. Acta Biochim Biophys Sin 2010, 42: 129-136.
12. Uhlendorff J, Matrosovich T, Klenk H and Matrosovich M. Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses. Arch Virol 2009, 154: 945-957.
13. Rambaut A, Pybus OG, Nelson MI, Viboud C, Taubenberger JK and Holmes EC. The genomic and epidemiological dynamics of human influenza A virus. Nature 2008, 453: 615-619.
14. Tamura K, Peterson D, Peterson N, Stecher G, Nei M and Kumar S. MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011, 28: 2731-2739.
15. Hall TA. BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/ 98/NT. Nucleic Acids Symp 1999, 41: 95-98.
16. Yen HL, Hoffmann E, Taylor G, Scholtissek C, Monto AS, Webster RG and Govorkova EA. Importance of neuraminidase active site residues to the neuraminidase inhibitor resistance of influenza viruses. J Virol 2006, 80: 8787-8795.
17. Kamps BS, Hoffmann C and Preiser W. Influenza Report 2006. Paris: Flying Publisher, 2006, 54-56.
18. Rajik M, Omar AR, Ideris A, Hassan SS and Yusoff K. A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells. Int J Biol Sci 2009, 5: 543-548.
19. Zhu S, Xue X, Liu J, Lu L, Zhao P, Wang J and Li W, et al. Expression of HPV6b L1/EBV LMP2 multiepitope and immunogenicity in mice. Acta Biochim Biophys Sin 2010, 42: 515-521.