Allele-specific siRNA knockdown as a personalized treatment strategy for vascular Ehlers-Danlos syndrome in human fibroblasts

FASEB Journal

Volumn 26, Issue 2, 2012, Pages 668-677

  Müller, Gerd A ^a,c   Hansen, Uwe ^b   Xu, Zhi ^a   Griswold, Benjamin ^a   Talan, Mark I ^a   McDonnell, Nazli B ^a   Briest, Wilfried ^a,d  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

Collagen; Extracellular matrix; RNA interference

Indexed keywords

COLLAGEN FIBER; SMALL INTERFERING RNA;

ADULT; ALLELE; ARTICLE; CASE REPORT; CELL STRESS; CONTROLLED STUDY; EHLERS DANLOS SYNDROME; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN UNFOLDING; RNA INTERFERENCE; TREATMENT PLANNING;

ALLELES; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CELLS, CULTURED; COLLAGEN TYPE III; EHLERS-DANLOS SYNDROME; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GENES, REPORTER; GENETIC THERAPY; HAPLOINSUFFICIENCY; HUMANS; INDIVIDUALIZED MEDICINE; LUCIFERASES; MICROSCOPY, IMMUNOELECTRON; MUTANT PROTEINS; MUTATION; MUTATION, MISSENSE; PHENOTYPE; RNA INTERFERENCE; RNA, SMALL INTERFERING; UNFOLDED PROTEIN RESPONSE;

EID: 84863020661     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-182162     Document Type: Article

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