Efficacy of ursodeoxycholic acid combined with Tongdan Decoction on immunological indices and histopathological changes in primary biliary cirrhosis patients

Chinese Journal of Integrative Medicine

Volumn 18, Issue 1, 2012, Pages 16-22

  Tong, Guang Dong ^a   Tang, Hai Hong ^a   Wei, Chun Shan ^a   Chen, Ying Jie ^a   He, Jin Song ^a   Zhou, Xiao Zhou ^a   Zheng, Ying Jun ^a   Zhou, Da Qiao ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Chinese medicine; combined treatment; immunology; pathology; primary biliary cirrhosis; ursodeoxycholic acid

Indexed keywords

CHINESE DRUG; DIAMMONIUM GLYCYRRHIZINATE; ESSENTIALE; GLYCYRRHIZIC ACID; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; STRONGER NEO MINOPHAGEN C; TIOPRONIN; TONGDAN DECOCTION; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ANTIGENS, CD; BIOLOGICAL MARKERS; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; IMMUNOGLOBULIN G; INFLAMMATION; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; URSODEOXYCHOLIC ACID;

EID: 84863019194     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-0112-0962-9     Document Type: Article

References (29)

1. P. Charatcharoenwitthaya K.D. Lindor 2005 Current concepts in the pathogenesis of primary biliary cirrhosis Ann Hepatol 4 161 175 16177655 1:CAS:528:DC%2BD28XjtlWltb8%3D
2. U. Leuschner 2003 Primary biliary cirrhosis-presentation and diagnosis Clin Liver Dis 7 741 758 14594129 10.1016/S1089-3261(03)00101-6 (Pubitemid 37229502)
3. Y. Dahlan L. Smith D. Simmonds L.D. Jewell I. Wanless E.J. Heathcote V.G. Bain 2003 Pediatric-onset primary biliary cirrhosis Gastroenterology 125 1476 1479 14598264 10.1016/j.gastro.2003.08.022 (Pubitemid 37409768)
4. T. Kumagi E.J. Heathcote 2008 Primary biliary cirrhosis Orphanet J Rare Dis 3 1 18215315 10.1186/1750-1172-3-1
5. F. Zhang J. Jia B. Wang L. Qian S. Yin Y. Wang, et al. 2002 Clinical characteristics of primary biliary cirrhosis: a report of 45 cases Chin J Int Med (Chin) 41 163 167
6. G.B. Yao 2002 A prospective study of primary biliary cirrhosis in Chinese patients Chin Hepatol (Chin) 7 146 149
7. J.L. Siegel R. Jorgensen P. Angulo K.D. Lindor 2003 Treatment with ursodeoxycholic acid is associated with weight gain in patients with primary biliary cirrhosis J Clin Gastroenterol 37 183 185 12869893 10.1097/00004836- 200308000-00018 1:CAS:528:DC%2BD3sXlvFClur0%3D (Pubitemid 36875583)
8. K. Lindor 2007 Ursodeoxycholic acid for the treatment of primary biliary cirrhosis N Engl J Med 357 1524 1529 17928600 10.1056/NEJMct074694 1:CAS:528:DC%2BD2sXhtFKmurbN (Pubitemid 47572638)
9. A. Pares J. Rodes 2000 Treatment of primary biliary cirrhosis Minerva Gastroenterol Dietol 46 165 174 16498378 1:STN:280:DC%2BD287htFeqsQ%3D%3D (Pubitemid 32155101)
10. R.E. Poupon B. Balkau E. Eschwege R. Poupon 1991 A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group N Engl J Med 324 1548 1554 1674105 10.1056/ NEJM199105303242204 1:STN:280:DyaK3M3is1CrsA%3D%3D
11. E.J. Heathcote K. Cauch-Dudek V. Walker R.J. Bailey L.M. Blendis C.N. Ghent, et al. 1994 The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 19 1149 1156 8175136 10.1002/hep.1840190512 1:STN:280:DyaK2c3ivFOntQ%3D%3D (Pubitemid 24134236)
12. J. Goulis G. Leandro A.K. Burroughs 1999 Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis Lancet 354 1053 1060 10509495 10.1016/S0140-6736(98)11293-X 1:CAS:528: DyaK1MXmsl2ltLc%3D (Pubitemid 29452816)
13. R.E. Poupon K.D. Lindor A. Pares O. Chazouilleres R. Poupon E.J. Heathcote 2003 Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis J Hepatol 39 12 16 12821038 10.1016/S0168-8278(03)00192-2 1:CAS:528:DC%2BD3sXkvVSqtL4%3D (Pubitemid 36724102)
14. P.C. ter Borg S.W. Schalm B.E. Hansen H.R. van Buuren 2006 Prognosis of ursodeoxycholic acid-treated patients with primary biliary cirrhosis. Results of a 10yr cohort study involving 297 patients Am J Gastroenterol 101 2044 2050 16848809 10.1111/j.1572-0241.2006.00699.x (Pubitemid 44337630)
15. J. Ludwig E.R. Dickson G.S. Mcdonald 1978 Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis) Virchows Arch A Pathol Anat Histol 379 103 112 150690 10.1007/BF00432479 1:STN:280:DyaE1c3ltF2qsg%3D%3D (Pubitemid 8388145)
16. Qiu DK, Ma X. Bases and clinics of autoimmune liver diseases. Shanghai: Shanghai Scientific and Technical Publishers (Chin); 2006.
17. + T cells as a regulatory subset in primary biliary cirrhosis Cell Mol Immunol 7 485 490 20729906 10.1038/cmi.2010.40 1:CAS:528:DC%2BC3cXhtlKjt7jE
18. Y. Zhang W.Z. Chen J.M. Shi 2010 Effect of estrogen receptor alpha gene polymorphism on the variations of T lymphocyte subsets and its related cell factors in female patients with primary cholestasis cirrhosis Chin J Hepatol (Chin) 18 740 744 1:CAS:528:DC%2BC3MXhtF2qs7o%3D
19. C.Z. Su H.H. Dong R. Zhong 2011 Treatment of primary biliary cirrhosis with Chinese medicine J China Tradit Chin Med Inform (Chin) 3 140
20. H. Tang Y. Chen G. Tong D. Zhou J. He X. Zhou Y. Zheng 2008 Efficacy of ursodeoxycholic acid combined with Tongdan Decoction in treatment of patients with primary biliary cirrhosis World Chin J Digestol (Chin) 16 1417 1424 (Pubitemid 352007052)
21. E.J. Heathcote 2000 Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines Hepatology 31 1005 1013 10733559 10.1053/he.2000.5984 1:STN:280:DC%2BD3c7pvVWktg%3D%3D
22. Chinese Medical Association. 2000 Prevention and solution of viral hepatitis Chin J Hepatol (Chin) 8 324
23. G. Chen L. Li J. Gao F. Li B. Li 2002 Primary biliary cirrhosis: an analysis of 153 cases Chin Med J (Chin) 82 1625 1628
24. P. Zhao L. Zhu D.K. Yao 2007 Progress in the study of recurrent primary biliary cirrhosis after orthotopic liver transplantation Chin J Hepatol (Chin) 15 396 398
25. R. Klein H. Pointner W. Zilly B. Glassner-Bittner N. Breuer W. Garbe, et al. 1997 Antimitochondrial antibody profiles in primary biliary cirrhosis distinguish at early stages between a benign and a progressive course: a prospective study on 200 patients followed for 10 years Liver 17 119 128 9249725 1:STN:280:DyaK2szptlajug%3D%3D (Pubitemid 27363862)
26. R. Klein J.R. Huizenga C.H. Gips P.A. Berg 1994 Antimitochondrial antibody profiles in patients with primary biliary cirrhosis before orthotopic liver transplantation and titres of antimitochondrial antibody-subtypes after transplantation J Hepatol 20 181 189 8006398 10.1016/S0168-8278(05)80056-X 1:STN:280:DyaK2c3nsFWgsA%3D%3D (Pubitemid 24086831)
27. W.J. Duan J.D. Jia 2009 Diagnosis and Management of Primary Biliary Cirrhosis Chin J Gastroenterol (Chin) 14 209 213
28. F. Bernuzzi D. Fenoglio F. Battaglia M. Fravega M.E. Gershwin F. Indiveri, et al. 2010 Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis J Autoimmun 35 176 180 20638239 10.1016/j.jaut.2010.06.004 1:CAS:528:DC%2BC3cXht12ltLnP
29. low/- regulatory T cells and their immunological functions in patients with primary biliary cirrhosis Chin J Hepatol (Chin) 16 620 621