Expression and significance of neurogenic differentiation protein in pancreatic carcinoma

Chinese Journal of Pathology

Volumn 41, Issue 1, 2012, Pages 23-27

  Wang, Yang ^a   Chen, Ying ^a   Gao, Li ^a   Zhu, Ming Hua ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Neurobiology; Pancreatic neoplasms; Proliferating cell nuclear antigen; Tumor suppressor protein p53

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLINE; NEUROD1 PROTEIN, HUMAN; PROTEIN P53; TP53 PROTEIN, HUMAN;

ADENOCARCINOMA; ADENOSQUAMOUS CARCINOMA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER INVASION; CYSTADENOCARCINOMA; CYSTADENOMA; FEMALE; HUMAN; LYMPH NODE METASTASIS; MALE; METABOLISM; MIDDLE AGED; PANCREAS TUMOR; PATHOLOGY; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, ADENOSQUAMOUS; CYSTADENOCARCINOMA, MUCINOUS; CYSTADENOMA, MUCINOUS; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PROLIFERATING CELL NUCLEAR ANTIGEN; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 84863015156     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0529-5807.2012.01.007     Document Type: Article

References (18)

1. Hiroshima K, Iyoda A, Shida T, et al. Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis. Mod Pathol, 2006, 19( 10) : 1358-1368. (Pubitemid 44423084)
2. Shida T, Furuya M, Kishimoto T, et al. The expression of NeuroD and mASHl in the gastroenteropancreatic neuroendocrine tumors. Mod Pathol, 2008,21(11) :1363-1370.
3. Fujii A, Kamiakito T, Takayashiki N, et al. Neuroendocrine tissue-specific transcription factor, BETA2/NeuroD, in gastric carcinomas: a comparison with chromogranin A and synaptophysin expressions. Pathol Res Pract, 2003,199(8) :513-519. (Pubitemid 37193073)
4. Bosnian FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system. Lyon: IARC Press, 2010.
5. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med, 1998,4(7) =844-847. (Pubitemid 28331029)
6. Rostomily RC, Bermingham-McDonogh O, Berger MS, et al. Expression of neurogenic basic helix-loop-helix genes in primitive neuroectodermal tumors. Cancer Res, 1997, 57( 16) :3526-3531. (Pubitemid 27355503)
7. Megiomi F, Mora B, Indovina P, et al. Expression of neuronal markers during NTera2/cloneDl differentiation by cell aggregation method. Neurosci Lett, 2005, 373(2) :105-109. (Pubitemid 39572970)
8. Bhat KM, Maddodi N, Shashikant C, et al. Transcriptional regulation of human MAP2 gene in melanoma; role of neuronal bHLH factors and Notchl signaling. Nucleic Acids Res, 2006, 34 (13):3819-3832. (Pubitemid 44400431)
9. Ochocinska MJ, Hitchcock PF. NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish. Mech Dev, 2009, 126(3-4) :128-141.
10. Ahnfelt-Rønne J, Hald J, Bødker A, et al. Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Dev Biol, 2007, 7:63.
11. Liu Y, Encinas M, Cornelia JX, et al. Basic helix-loop-helix proteins bind to TrkB and p21 (Cipl) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. Mol Cell Biol, 2004, 24(7) =2662-2672. (Pubitemid 38381259)
12. Demir IE, Ceyhan GO, Rauch U, et al. The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity. Neurogastroenterol Motil, 2010, 22(4) :480-490.
13. Shimada K, Nara S, Esaki M, et al. Intrapancreatic nerve invasion as a predictor for recurrence after pancreaticoduodenectomy in patients with invasive ductal carcinoma of the pancreas. Pancreas, 2011, 40(3) ;464-468.
14. Kayahara M, Nakagawara H, Kitagawa H, et al. The nature of neural invasion by pancreatic cancer. Pancreas,2007,35(3) =218- 223. (Pubitemid 47482513)
15. Westerman BA, Poutsma A, Maruyama K, et al. The proneural genes NEUR0D1 and NEUROD2 are expressed during human trophoblast invasion. Mech Dev, 2002, 113(1): 85-90. (Pubitemid 34233729)
16. Naya FJ, Stellrecht CM, Tsai MJ. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev, 1995, 9(8) :1009-1019.
17. Brazelton TR, Rossi FM, Keshet Gl, et al. From marrow to brain; expression of neuronal phenotypes in adult mice. Science, 2000, 290(5497); 1775-1779. (Pubitemid 32004810)
18. Lee JE, Hollenberg SM, Snider L, et al. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science, 1995, 268(5212): 836-844.