Synthesis of (-)-arctigenin derivatives and their anticancer activity

Natural Product Research

Volumn 26, Issue 2, 2012, Pages 177-181

  Chen, Gui Rong ^a   Cai, Li Ping ^a   Dou, De Qiang ^a   Kang, Ting Guo ^a   Li, Hong Fu ^a   Li, Fu Rui ^a   Jiang, Ning ^a  

^a LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

( ) arctigenin; anticancer bioactivity; synthesis; synthetic derivatives

Indexed keywords

ANTINEOPLASTIC AGENT; ARCTIGENIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FRUCTUS ARCTII; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ALKYLATION; ANTINEOPLASTIC AGENTS; ARCTIUM; BUTYLAMINES; CELL LINE, TUMOR; CELL SURVIVAL; ETHYLAMINES; FRUIT; FURANS; HUMANS; INHIBITORY CONCENTRATION 50; LIGNANS; METHYLAMINES; MOLECULAR STRUCTURE;

EID: 84863011975     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2010.541874     Document Type: Article

References (4)

1. Echart, E, Heinz, P, Macki, K, Jutta, S, Mark, RF, Abhijit, M, and, Yves, P. 1996. (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase. Journal of Medicinal Chemistry, 29: 86-95.
2. Qiu, YK., Dou, DQ, Cai, LP, Jiang, HP, Kang, TG, Yang, BY, Michael, ZCL. 2009. Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells. Fitoterapia, 80: 219-222.
3. Suresh, A, Jie, L, Surya, KK, Yukiko, K, Yasuhiro, T, Shigetoshi, K, and, Hiroyasu, E. 2006. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Research, 66: 1751-1757.
4. Takasi, M, Konoshtma, T, Bardeesy, N, Sharpless, NE, and, DePinho, R. 2000. Antitumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Letter, 158: 53-59.