Dexmedetomidine and clonidine in epidural anaesthesia: A comparative evaluation

Indian Journal of Anaesthesia

Volumn 55, Issue 2, 2011, Pages 116-121

  Bajwa, Sukhminder Jit Singh ^a   Bajwa, Sukhwinder Kaur ^b   Kaur, Jasbir ^a   Singh, Gurpreet ^a   Arora, Vikramjit ^a   Gupta, Sachin ^a   Kulshrestha, Ashish ^a   Singh, Amarjit ^a   Parmar, S S ^a   Singh, Anita ^b   Goraya, S P S ^b  

^a Departments of Anaesthesiology and Intensive Care   (India)

^b GIAN SAGAR MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

Clonidine; Dexmedetomidine; Epidural anaesthesia; Ropivacaine; Vaginal hysterectomy

Indexed keywords

CLONIDINE; DEXMEDETOMIDINE; ROPIVACAINE;

ADULT; AGED; ANALGESIA; ANESTHESIA LEVEL; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; EPIDURAL ANESTHESIA; FEMALE; HEADACHE; HUMAN; INTRAOPERATIVE PERIOD; MAJOR CLINICAL STUDY; NAUSEA; NERVE BLOCK; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SEDATION; SHIVERING; VAGINAL HYSTERECTOMY; VOMITING; XEROSTOMIA;

EID: 84863011744     PISSN: 00195049     EISSN: None     Source Type: Journal    
DOI: 10.4103/0019-5049.79883     Document Type: Article

References (41)

1. Höhener D, Blumenthal S, Borgeat A. Sedation and regional anaesthesia in the adult patient. Br J Anaesth 2008;100:8-16.
2. Helgeson LE. Sedation during regional anaesthesia: Inhalational versus intravenous. Curr Opin Anaesthesiol 2005;18:534-9.
3. Nemethy M, Paroli L, Williams-Russo PC, Blanck TJ. Assessing sedation with regional anaesthesia: Inter-rater agreement on a modified Wilson Sedation Scale. Anesth Analg 2002;94:723-8.
4. Asehnoune K, Albaladejo P, Smail N, Heriche C, Sitbon P, Gueneron JP, et al. Information and anaesthesia: What does the patient desire? Ann Fr Anesth Reanim 2000;19:577-81.
5. Badner NH, Nielson WR, Munk S, Kwiatkowska C, Gelb AW. Preoperative anxiety: Detection and contributing factors. Can J Anaesth 1990;37:444-7.
6. Schnider TW, Minto CF. Predictors of onset and offset of drug effect. Eur J Anaesthesiol 2001;23:26-31.
7. McNamee DA, Parks L, McClelland AM, Scott S, Milligan KR, Ahlén K, et al. Intrathecal ropivacaine for total hip arthroplasty: Double-blind comparative study with isobaric 7.5mg. ml-1 and 10mg. ml-1 solutions. Br J Anaesth 2001;87:743-7.
8. Kamibayashi T, Maze M. Clinical uses of alpha-2 adrenergic agonists. Anaesthesiology 2000;93:1345-9.
9. Scafati A. Analgesia and alpha agonists 2. Medens Rev 2004;4-7.
10. Mauro VA, Brandão ST. Clonidine and dexmedetomidine through epidural route for post-operative analgesia and sedation in a colecistectomy. Rev Bras Anestesiol 2004;4:1-10.
11. Gabriel JS, Gordin V. Alpha 2 agonists in regional anaesthesia and analgesia. Curr Opin Anaesthesiol 2001;14:751-3.
12. Hall JE, Uhrich TD, Ebert TJ. Sedative, analgesic and cognitive effects of clonidine infusions in humans. Br J Anaesth 2001;86:5-11.
13. Hall JE, Uhrich TD, Barney JA, Arain SR, Ebert TJ. Sedative, amnesic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg 2000;90:699-705.
14. Bucklin B, Eisenach JC, Tucker B. Pharmacokinetics and dynamic studies of intrathecal, epidural and intravenous dexmedetomidine. Anaesthesiology 1991;75(suppl):662.
15. Bischoff P, Kochs E. Alpha2-agonists in anaesthesia and intensive medicine. Anasthesiol Intensivmed Notfallmed Schmerzther 1993;28:2-12.
16. Ribeiro RN, Nascimento JP. The use of dexmedetomidine in anesthesiology. Rev Bras Anestesiol 2003;53:97-113.
17. Linde H e Mo. The clinical use of dexmedetomidine. Rev Bras Anestesiol 2004;54:1-4.
18. Schnaider TB, Vieira AM, Brandão AC, Lobo MV. Intra-operative analgesic effect of cetamine, clonidine and dexmedetomidine, administered through epidural route in surgery of the upper abdomen. Rev Bras Anestesiol 2005;55:525-31.
19. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology 2000;93:382-94.
20. Milligan KR, Convery PN, Weir P. The efficacy and safety of epidural infusions of levobupivacaine with and without clonidine for postoperative pain relief in patients undergoing total hip replacement. Anesth Analg 2000;91:393-7.
21. Klimscha W, Chiari A, Krafft P. Hemodynamic and analgesic effects of clonidine added repetitively to continuous epidural and spinal blocks. Anesth Analg 1995;80:322-7.
22. Fukushima K, Nishimi Y, Mori K. The effect of epidural administered dexmedetomidine on central and peripheral nervous system in man. Anesth Analg 1997;84:S292.
23. 2-adrenoceptor agonists. Baillière's Clin Anaesth 2000;14:247-60.
24. Correa-Sales C. A hypnotic response to dexmedetomidine, an alpha-2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology 1992;76:948-52.
25. Taittonen MT, Kirvelä OA, Aantaa R, Kanto JH. Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state. Br J Anaesth 1997;78:400-6.
26. 2-adrenoceptor agonists. Baillière's Clin Anaesth 2000;14:411-8.
27. Filos KS, Goudas LC, Patroni O, Polizou V. Hemodynamic and analgesic profile after intrathecal clonidine in humans. A doseresponse study. Anesthesiology 1994;81:591-601.
28. Chiary A, Lorber C, Eisnach JC, Wildling E, Krenn C, Zavrsky A, et al. Analgesic and hemodynamic effects of intrathecal clonidine as the sole analgesic agent during first stage of labor. Anesthesiology 1999;91:388-96.
29. Arian SR, Ruehlow RM, Uhrich TD, Ebert TJ. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg 2004;98:153-8.
30. Gertler R, Brown HC, Mitchell DH, Silvius EN. Dexmedetomidine: A novel sedative-analgesic agent. Proc (Bayl Univ Med Cent) 2001;14:13-21.
31. Paris A, Tonner PH. Dexmedetomidine in anaesthesia. Curr Opin Anaesthesiol 2005;18:412-8.
32. Coskuner I, Tekin M, Kati I. Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block. Eur J Anaesthesiol 2007;24:535-40.
33. El-Hennawy AM, Abd-Elwahab AM, Abd-Elmaksoud AM, El-Ozairy HS, Boulis SR. Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. Br J Anaesth 2009;103:268-74.
34. Sia AT. Optimal dose of intrathecal clonidine added to sufentanil plus bupivacaine for labour analgesia. Can J Anaesth 2000;47:875-80.
35. Benhamou D, Thorin D, Brichant JF, Dailand P, Milon D, Schneider M. Intrathecal clonidine and fentanyl with hyperbaric bupivacaine improves analgesia during cesarean section. Anesth Analg 1998;87:609-13.
36. Aantaa R, Kanto J, Scheinin M, Kallio A, Scheinin H. Dexmedetomidine, an alpha 2-adrenoceptor agonist, reduces anesthetic requirements for patients undergoing minor gynaecologic surgery. Anesthesiology 1990;73:230-5.
37. Ogun CO, Kirgiz EN, Duman A, Kara I, Okesli S. The comparison of intrathecal isobaric ropivacaine and isobaric ropivacaineclonidine for caesarean delivery. Internet J Anesthesiol 2007;15:1.
38. El Saied AH, Steyn MP, Ansermino JM. Clonidine prolongs the effect of ropivacaine for axillary brachial plexus blockade. Can J Anaesth 2000;47:962-7.
39. Cortinez LI, Hsu YW, Sum-Ping ST, Young C, Keifer JC, Macleod D, et al. Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 2004;101:1077-83.
40. Mato M, Pérez A, Otero J, Torres LM. Dexmedetomidine, a promising drug. Rev Esp Anestesiol Reanim 2002;49:407-20.
41. Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs 2000;59:263-8.