Human ABCC1 interacts and colocalizes with ATP synthase α, revealed by interactive proteomics analysis

Journal of Proteome Research

Volumn 11, Issue 2, 2012, Pages 1364-1372

  Yang, Youyun ^a   Li, Zhaomin ^a   Mo, Wei ^a   Ambadipudi, Raghuram ^b   Arnold, Randy J ^c   Hrncirova, Petra ^c   Novotny, Milos V ^c   Georges, Elias ^b   Zhang, Jian Ting ^a  

^a INDIANA UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c INDIANA UNIVERSITY   (United States)

Author keywords

ABC transporter; ABCC1; ATP synthase; drug resistance; MRP1; oligomers

Indexed keywords

ABC TRANSPORTER; ABCC1 PROTEIN; ADENOSINE TRIPHOSPHATASE; ATP SYNTHASE ALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPRECIPITATION; NANOANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL ELECTROPHORESIS;

AMINO ACID SEQUENCE; BINDING SITES; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEOMICS; REPRODUCIBILITY OF RESULTS;

EID: 84863010960     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr201003g     Document Type: Article

References (23)

1. Holland, I. B.; Cole, S. P.; Kuchler, K.; Higgins, C. F. ABC proteins, from bacteria to man; Academic Press: London, U.K., 2003.
2. Kim, I. W.; Booth-Genthe, C.; Ambudkar, S. V. Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1) Mini Rev. Med. Chem. 2008, 8 (3) 193-200
3. Sharom, F. J. ABC multidrug transporters: structure, function and role in chemoresistance Pharmacogenomics 2008, 9 (1) 105-27
4. Zhang, J. T. Use of arrays to investigate the contribution of ATP-binding cassette transporters to drug resistance in cancer chemotherapy and prediction of chemosensitivity Cell Res. 2007, 17 (4) 311-23
5. Mo, W.; Liu, J. Y.; Zhang, J. T. Biochemistry and pharmacology of human ABCC1/MRP1 and its role in detoxification and in multidrug resistance of cancer chemotherapy. In Recent Advances on Cancer Research and Therapy; Pestka, S.; Shi, Y.; Liu, X. Y., Eds.; Elsevier: Oxford, United Kingdom, 2011; In press.
6. Yang, Y.; Chen, Q.; Zhang, J. T. Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1 J. Biol. Chem. 2002, 277 (46) 44268-77
7. Chen, Q.; Yang, Y.; Li, L.; Zhang, J. T. The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function J. Biol. Chem. 2006, 281 (41) 31152-63
8. Chen, Q.; Yang, Y.; Liu, Y.; Han, B.; Zhang, J. T. Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1 Biochemistry 2002, 41 (29) 9052-62
9. Yang, Y.; Liu, Y.; Dong, Z.; Xu, J.; Peng, H.; Liu, Z.; Zhang, J. T. Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1 J. Biol. Chem. 2007, 282 (12) 8821-30
10. Yang, Y.; Mo, W.; Zhang, J. T. Role of transmembrane segment 5 and extracellular loop 3 in the homodimerization of human ABCC1 Biochemistry 2010, 49 (51) 10854-61
11. Georges, E. The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins Biochemistry 2007, 46 (25) 7337-42
12. Xu, J.; Liu, Y.; Yang, Y.; Bates, S.; Zhang, J. T. Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2 J. Biol. Chem. 2004, 279 (19) 19781-9
13. Dong, Z.; Zhang, J. T. EIF3 p170, a Mediator of Mimosine Effect on Protein Synthesis and Cell Cycle Progression Mol. Biol. Cell 2003, 14 (9) 3942-51
14. Liu, Y.; Chen, Q.; Zhang, J. T. Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling J. Proteome Res. 2004, 3 (4) 728-35
15. Dong, Z.; Arnold, R. J.; Yang, Y.; Park, M. H.; Hrncirova, P.; Mechref, Y.; Novotny, M. V.; Zhang, J. T. Modulation of differentiation-related gene 1 expression by cell cycle blocker mimosine, revealed by proteomic analysis Mol. Cell. Proteomics 2005, 4 (7) 993-1001
16. Liu, Y.; Liu, H.; Han, B.; Zhang, J. T. Identification of 14-3-3sigma as a contributor to drug resistance in human breast cancer cells using functional proteomic analysis Cancer Res. 2006, 66 (6) 3248-55
17. Perkins, D. N.; Pappin, D. J.; Creasy, D. M.; Cottrell, J. S. Probability-based protein identification by searching sequence databases using mass spectrometry data Electrophoresis 1999, 20 (18) 3551-67
18. Moser, T. L.; Stack, M. S.; Wahl, M. L.; Pizzo, S. V. The mechanism of action of Angiostatin: can you teach an old dog new tricks? Thromb. Haemost. 2002, 87 (3) 394-401
19. Burnstock, G. Purine and pyrimidine receptors Cell. Mol. Life Sci. 2007, 64 (12) 1471-83
20. Lavie, Y.; Fiucci, G.; Liscovitch, M. Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells J. Biol. Chem. 1998, 273 (49) 32380-3
21. Chi, S. L.; Pizzo, S. V. Cell surface F1Fo ATP synthase: a new paradigm? Ann. Med. 2006, 38 (6) 429-38
22. Moser, T. L.; Stack, M. S.; Asplin, I.; Enghild, J. J.; Hojrup, P.; Everitt, L.; Hubchak, S.; Schnaper, H. W.; Pizzo, S. V. Angiostatin binds ATP synthase on the surface of human endothelial cells Proc. Natl. Acad. Sci. U.S.A. 1999, 96 (6) 2811-6
23. Klappe, K.; Hummel, I.; Hoekstra, D.; Kok, J. W. Lipid dependence of ABC transporter localization and function Chem. Phys. Lipids 2009, 161 (2) 57-64