Effects of intraperitoneal administration of gabapentin on the minimum alveolar concentration of isoflurane in adult male rats

Laboratory Animals

Volumn 46, Issue 2, 2012, Pages 108-113

  Boruta, D T ^a   Sotgiu, G ^b   Golder, F J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

Anaesthesia; Gabapentin; Isoflurane; MAC; MAC sparing effect; Rats

Indexed keywords

G 1092 25 GM; GABAPENTIN; ISOFLO; ISOFLURANE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; AMINE; ANTICONVULSIVE AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; INHALATION ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; BLOOD GAS ANALYSIS; CHRONIC PAIN; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MEGADOSE; END TIDAL CARBON DIOXIDE TENSION; HYPOTHESIS; LINEAR REGRESSION ANALYSIS; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NEUROPATHIC PAIN; NONHUMAN; RAT; SEIZURE; SINGLE DRUG DOSE; ANIMAL; INHALATION ANESTHESIA; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG ALVEOLUS; METABOLISM; SPRAGUE DAWLEY RAT;

AMINES; ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; ANIMALS; ANTICONVULSANTS; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, INTRAPERITONEAL; ISOFLURANE; MALE; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84863007845     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2011.011127     Document Type: Article

References (23)

1. Crawford P, Ghadiali E, Lane R, Blumhardt L, Chadwick D. Gabapentin as an antiepileptic drug in man. J Neurol Neurosurg Psychiatry 1987; 50: 682-6
2. Segal AZ, Rordorf G. Gabapentin as a novel treatment for postherpetic neuralgia. Neurology 1996; 46: 1175-6
3. Zochodne DW. Diabetic neuropathies. Curr Treat Options Neurol 2000; 2: 23-30
4. Ho K, Gan T, Habib A. Gabapentin and postoperative pain: a systematic review of randomized controlled trials. Pain 2006; 126: 91-101
5. Cheng J, Chiou L. Mechanism of the antinociceptive action of gabapentin. J Pharmacol Sci 2006; 100: 471-86
6. Shimoyama N, Shimoyama M, Davis AM, Inturrisi CE, Elliott KJ. Spinal gabapentin is antinociceptive in the rat formalin test. Neurosci Lett 1997; 222: 65-7
7. Grabow TS, Dougherty PM. Gabapentin produces dose-dependent antinociception in the orofacial formalin test in the rat. Reg Anesth Pain Med 2002; 27: 277-83
8. Feng Y, Cui M, Willis WD. Gabapentin markedly reduces acetic acid-induced visceral nociception. Anesthesiology 2003; 98: 729-33
9. Kazi J, Gee CF. Effect of gabapentin on c-Fos expression in the CNS after paw surgery in rats. J Mol Neurosci 2007; 32: 228-34
10. Reid P, Pypendop BH, Ilkiw JE. The effects of intravenous gabapentin administration on the minimum alveolar concentration of isoflurane in cats. Anaesth Analg 2010; 111: 633-7
11. Golder FJ, Pascoe PJ, Bailey CS, Ilkiw JE, Tripp LD. The effect of epidural morphine on the minimum alveolar concentration of isoflurane in cats. Vet Anaesth Analg 1998; 25: 52-6
12. Quasha AL, Eger EI, Tinker JH. Determination and applications of MAC. Anesthesiology 1980; 53: 315-34
13. Liu Y, Uboh CE, Soma LR, et al. Analysis of gabapentin in equine plasma with measurement uncertainty estimation by liquid chromatography-tandem mass spectrometry. J Anal Toxicol 2011; 35: 75-84
14. Sidak Z. Rectangular confidence regions for means of multivariate normal distributions. J Am Stat Assoc 1967; 67: 626-33
15. Keppel G, Wickens TD. Design and Analysis: A Researcher's Handbook. 4th edn. Upper Saddle River, NJ: Pearson Education International, 2004
16. Gaines Das R, North D. Implications of experimental techniques for analysis and interpretation of data from animal experiments: outliers and increased variability resulting from failure of intraperitoneal procedures. Lab Anim 2007; 41: 312-20
17. Gatti G, Ferrari AR, Guerrini R, Bonanni P, Bonomi I, Perucca E. Plasma gabapentin in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response. Ther Drug Monit 2003; 25: 54-60
18. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg 2000; 91: 185-91
19. Kusunose N, Koyanagi S, Hamamura K, et al. Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. Molecular Pain 2010; 83: 1-8
20. Ross EM. Pharmacodynamics - mechanisms of drug action and the relationship between drug concentration and effect. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 9th edn. New York: McGraw-Hill, 1996: 29-41
21. Yoon MH, Choi JI. Hemodynamic effects of gabapentin in rats. J Korean Med Sci 2003; 18: 478-82
22. Clarke H, Pereira S, Kennedy D, et al. Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption, or chronic pain after total hip arthroplasty. Acta Anesthesiol Scand 2009; 53: 1073-83
23. Staahl C, Olesen AE, Andresen T, Arendt-Nielsen L, Drewes AM. Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review. Br J Clin Pharmacol 2009; 68: 322-41