Expression of platelet-derived growth factor-C and insulin-like growth factor i in hepatic stellate cells is inhibited by miR-29

Laboratory Investigation

Volumn 92, Issue 7, 2012, Pages 978-987

  Kwiecinski, Monika ^a   Elfimova, Natalia ^a   Noetel, Andrea ^a   Töx, Ulrich ^a   Steffen, Hans Michael ^a   Hacker, Ulrich ^a   Nischt, Roswitha ^a   Dienes, Hans Peter ^a   Odenthal, Margarete ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

hepatic stellate cells; IGF I; liver fibrogenesis; microRNA 29; miR 29 targets; myofibroblasts; PDGF C

Indexed keywords

MICRORNA 29; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR C; SCLEROPROTEIN; SOMATOMEDIN C; VASCULOTROPIN A;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BILE DUCT OBSTRUCTION; BINDING SITE; CELL DIFFERENTIATION; GENE TARGETING; LIVER CELL; LIVER FIBROSIS; MOLECULAR CLONING; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEQUENCE ANALYSIS; STELLATE CELL; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION; HEPATIC STELLATE CELLS; INSULIN-LIKE GROWTH FACTOR I; LIVER CIRRHOSIS, EXPERIMENTAL; LYMPHOKINES; MICRORNAS; MYOFIBROBLASTS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, WISTAR; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863002362     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.70     Document Type: Article

References (57)

1. Kozomara A, Griffiths-Jones S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 2011;39, (database issue) D152-D157.
2. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;2:215-233.
3. Ambros V. The functions of animal microRNAs. Nature 2004;7006: 350-355. (Pubitemid 39265675)
4. Varnholt H, Drebber U, Schulze F, et al. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 2008;4:1223-1232. (Pubitemid 351547908)
5. Gramantieri L, Fornari F, Callegari E, et al. MicroRNA involvement in hepatocellular carcinoma. J Cell Mol Med 2008;6A:2189-2204.
6. Braconi C, Henry JC, Kogure T, et al. The role of microRNAs in human liver cancers. Semin Oncol 2011;6:752-763.
7. Cheung O, Puri P, Eicken C, et al. Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology 2008;6:1810-1820.
8. Jin X, Ye YF, Chen SH, et al. MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease. Dig Liver Dis 2009;4:289-297.
9. Morita K, Taketomi A, Shirabe K, et al. Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C. Liver Int 2011;4:474-484.
10. Chang Y, Jiang HJ, Sun XM, et al. Hepatic stellate cell-specific gene silencing induced by an artificial microRNA for antifibrosis in vitro. Dig Dis Sci 2010;3:642-653.
11. Lakner AM, Bonkovsky HL, Schrum LW. microRNAs: fad or future of liver disease. World J Gastroenterol 2011;20:2536-2542.
12. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008;6:1655-1669. (Pubitemid 351615417)
13. Schuppan D, Krebs A, Bauer M, et al. Hepatitis C and liver fibrosis. Cell Death Differ 2003;10:S59-S67. (Pubitemid 36511853)
14. Kisseleva T, Uchinami H, Feirt N, et al. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 2006;3:429-438. (Pubitemid 44142115)
15. Knittel T, Kobold D, Saile B, et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999;5:1205-1221. (Pubitemid 29512681)
16. Schuppan D, Porov Y. Hepatic fibrosis: from bench to bedside. J Gastroenterol Hepatol 2002;17:S300-S305. (Pubitemid 35454302)
17. Ramadori G, Veit T, Schwogler S, et al. Expression of the gene of the alpha-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells. Virchows Arch B Cell Pathol Incl Mol Pathol 1990;6:349-357.
18. Mann J, Chu DC, Maxwell A, et al. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology 2010;2:705-714 714 e1-4.
19. Guo CJ, Pan Q, Cheng T, et al. Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways. FEBS J 2009;18:5163-5176.
20. Ji J, Zhang J, Huang G, et al. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett 2009;4:759-766.
21. Guo CJ, Pan Q, Jiang B, et al. Effects of upregulated expression of microRNA-16 on biological properties of culture-activated hepatic stellate cells. Apoptosis 2009;11:1331-1340.
22. Sekiya Y, Ogawa T, Iizuka M, et al. Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-beta-induced inhibition of hepatic stellate cell proliferation. J Cell Physiol 2010;10:2535-2542.
23. Chen C, Wu CQ, Zhang ZQ, et al. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation. Exp Cell Res 2011;12:1714-1725.
24. Lakner AM, Steuerwald NM, Walling TL, et al. Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis. Hepatology 2012 (in press).
25. Venugopal SK, Jiang J, Kim TH, et al. Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells and their over-expression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol 2010;1:G101-G106.
26. Roderburg C, Urban GW, Bettermann K, et al. Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology 2011;1:209-218.
27. Kwiecinski M, Noetel A, Elfimova N, et al. Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction. PLoS One 2011;9:e24568.
28. Maurer B, Stanczyk J, Jungel A, et al. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum 2010; 6:1733-1743.
29. Ogawa T, Iizuka M, Sekiya Y, et al. Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun 2010;1:316-321.
30. van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008;35:13027-13032.
31. Mott JL, Kobayashi S, Bronk SF, et al. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007;42:6133-6140. (Pubitemid 47414372)
32. Wang H, Garzon R, Sun H, et al. NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 2008;5:369-381.
33. John B, Enright AJ, Aravin A, et al. Human MicroRNA targets. PLoS Biol 2004;11:e363.
34. Creighton CJ, Nagaraja AK, Hanash SM, et al. A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions. Rna 2008;11:2290-2296.
35. Krek A, Grun D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet 2005;5:495-500. (Pubitemid 40617277)
36. Geerts A, Vrijsen R, Rauterberg J, et al. In vitro differentiation of fatstoring cells parallels marked increase of collagen synthesis and secretion. J Hepatol 1989;1:59-68. (Pubitemid 19181364)
37. Vogel S, Piantedosi R, Frank J, et al. An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J Lipid Res 2000;6:882-893. (Pubitemid 30434319)
38. Siebolts U, Varnholt H, Drebber U, et al. Tissues from routine pathology archives are suitable for microRNA analyses by quantitative PCR. J Clin Pathol 2009;1:84-88.
39. Boigk G, Stroedter L, Herbst H, et al. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology 1997;3:643-649. (Pubitemid 27392355)
40. Tox U, Scheller I, Kociok N, et al. Expression of angiotensin II receptor type 1 is reduced in advanced rat liver fibrosis. Dig Dis Sci 2007; 8:1995-2005. (Pubitemid 47024643)
41. Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005;7027:769-773. (Pubitemid 40292988)
42. Wang X, Wang X. Systematic identification of microRNA functions by combining target prediction and expression profiling. Nucleic Acids Res 2006;5:1646-1652.
43. Park SY, Lee JH, Ha M, et al. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 2009;1:23-29.
44. Xiong Y, Fang JH, Yun JP, et al. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010;3:836-845.
45. Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 2007;40:15805-15810. (Pubitemid 350035380)
46. Reeves HL, Friedman SL. Activation of hepatic stellate cells-a key issue in liver fibrosis. Front Biosci 2002;7:d808-d826.
47. Sekiya Y, Ogawa T, Yoshizato K, et al. Suppression of hepatic stellate cell activation by microRNA-29b. Biochem Biophys Res Commun 2011;1:74-79.
48. Breitkopf K, Roeyen C, Sawitza I, et al. Expression patterns of PDGF-A,-B,-C and-D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Cytokine 2005;5:349-357. (Pubitemid 41188056)
49. Svegliati-Baroni G, Ridolfi F, Di Sario A, et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology 1999;6:1743-1751. (Pubitemid 29247048)
50. Saile B, DiRocco P, Dudas J, et al. IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF). Lab Invest 2004;8:1037-1049. (Pubitemid 39025038)
51. Bridle KR, Li L, O0Neill R, et al. Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells. J Lab Clin Med 2006;5: 234-241. (Pubitemid 43668485)
52. Novosyadlyy R, Dudas J, Pannem R, et al. Crosstalk between PDGF and IGF-I receptors in rat liver myofibroblasts: implication for liver fibrogenesis. Lab Invest 2006;7:710-723. (Pubitemid 43901668)
53. Bandyopadhyay S, Friedman RC, Marquez RT, et al. Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture. J Infect Dis 2011;12:1753-1762.
54. Gilbertson DG, Duff ME, West JW, et al. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem 2001;29:27406-27414.
55. Li X, Ponten A, Aase K, et al. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol 2000;5:302-309.
56. Campbell JS, Hughes SD, Gilbertson DG, et al. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci USA 2005;9:3389-3394. (Pubitemid 40328055)
57. Scharf JG, Dombrowski F, Ramadori G. The IGF axis and hepatocarcinogenesis. Mol Pathol 2001;3:138-144. (Pubitemid 32539603)