A miniature, single use, skin-adhered, low-voltage, electroosmotic pumping-based subcutaneous infusion system

Drug Delivery and Translational Research

Volumn 1, Issue 4, 2011, Pages 342-347

  Shin, Woonsup ^a,b   Shin, Samuel Jaeho ^a   Lee, Jong Myung ^a,b   Nagarale, Rajaram Krishna ^a   Heller, Adam ^a  

^a The University of Texas at Austin   (United States)

^b Sogang University   (South Korea)

Author keywords

Drug pumps; Infusion systems; Subcutaneous infusion; Transdermal drug infusion

Indexed keywords

INSULIN; OIL; SILVER; WATER;

ARTICLE; CERAMICS; DRUG DELIVERY SYSTEM; DRUG INFUSION; ELECTRIC POTENTIAL; ELECTRODE; ELECTROLYSIS; ELECTROOSMOSIS; FLOW RATE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NEEDLE; OSMOTIC PUMP; POROSITY; PRIORITY JOURNAL; THERMODYNAMICS;

EID: 84862988686     PISSN: 2190393X     EISSN: 21903948     Source Type: Journal    
DOI: 10.1007/s13346-011-0021-7     Document Type: Article

References (12)

1. Alsaleh FM, Smith FJ, Keady S, Taylor KMG. Insulin pumps: from inception to the present and toward the future. J Clin Pharm Ther. 2010; 35: 127-38.
2. Chen L, Lee S, Choo J, Lee EK. Continuous dynamic flow micropumps for microfluid manipulation. J Micromech Microeng. 2008; 18: 1-22.
3. Evans AT, Park JM, Chiravuri S, Gianchandani YB. A low power, microvalve regulated architecture for drug delivery systems. Biomed Microdev. 2010; 12: 159-68.
4. Kim D, Posner JD, Santiago JG. High flow rate per power electroosmotic pumping using low ion density solvents. Sens Actuators A. 2008; A141: 201-12.
5. Litster S, Suss ME, Santiago JG. A two-liquid electroosmotic pump using low applied voltage and power. Sens Actuators A. 2010; A163: 311-4.
6. NFT Electro-Osmotic Pumps. NanoFusion-Technologies, Tokyo. 2010. http://www. nft-eop. co. jp/en/index. html.
7. Nie F-Q, Macka M, Barron L, Connolly D, Kent N, Paull B. Robust monolithic silica-based on-chip electro-osmotic micro-pump. Analyst. 2007; 132: 417-24.
8. Paudel KS, Milewski M, Swadley CL, Brogden NK, Ghosh P, Stinchcomb AL. Challenges and opportunities in dermal/transdermal delivery. Ther Delivery. 2010; 1: 109-31.
9. Potti LG, Haines ST. Continuous subcutaneous insulin infusion therapy: a primer on insulin pumps. J Am Pharm Assoc. 2009; 49: e1-13. quiz e4-7.
10. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008; 26: 1261-8.
11. Shin W, Lee JM, Nagarale RK, Shin SJ, Heller A. A miniature, non-gassing electroosmotic pump operating at 0. 5 V. J Am Chem Soc. 2011; 133: 2374.
12. Tsai NC, Sue CY. Review of MEMS-based drug delivery and dosing systems. Sens Actuators A. 2007; 134: 555-64.