Small interfering RNA targeting Krüppel-like factor 8 inhibits U251 glioblastoma cell growth by inducing apoptosis

Molecular Medicine Reports

Volumn 5, Issue 2, 2012, Pages 347-350

  Wan, Weifeng ^a   Zhu, Ji ^a   Sun, Xiaochuan ^a   Tang, Wenyuan ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Glioblastoma; Kr ppel like factor 8; Proliferation; Small interfering RNA

Indexed keywords

KRUPPEL LIKE FACTOR 8; NUCLEIC ACID BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CONTROLLED STUDY; DOWN REGULATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; TUMOR CELL; TUMOR GROWTH;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; G2 PHASE; GLIOBLASTOMA; HUMANS; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84862975489     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.669     Document Type: Article

References (23)

1. Voelzke WR, Petty WJ and Lesser GJ: Targeting the epidermal growth factor receptor in high-grade astrocytomas. Curr Treat Opt Oncol 9: 23-31, 2008.
2. Ohgaki H and Kleihues P: Epidemiology and etiology of gliomas. Acta Neuropathol 109: 93-108, 2005. (Pubitemid 40287792)
3. Wrensch M, Minn Y, Chew T, et al: Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol 4: 278-299, 2002.
4. Schwartzbaum JA, Fisher JL, Aldape KD, et al: Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol 2: 494-503, 2006. (Pubitemid 44275725)
5. Elbashir S, Harborth J, Lendeckel W, et al: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001. (Pubitemid 32494397)
6. Pearson R, Fleetwood J, Eaton S, et al: Krüppel-like transcription factors: a functional family. Int J Biochem Cell Biol 40: 1996-2001, 2008. (Pubitemid 352004270)
7. Zhao J, Bian ZC, Yee K, et al: Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell 11: 1503-1515, 2003. (Pubitemid 36776537)
8. Wang X and Zhao J: KLF8 transcription factor participates in oncogenic transformation. Oncogene 26: 456-461, 2007. (Pubitemid 46122835)
9. Quadrini KJ and Bieker JJ: Krüppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Krüppel-like factor. J Biol Chem 277: 32243-32252, 2002. (Pubitemid 34969040)
10. Wang X, Urvalek AM, Liu J, et al: Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. J Biol Chem 283: 13934-13942, 2008.
11. Wei H, Wang X, Gan B, et al: Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. J Biol Chem 281: 16664-16671, 2006.
12. Ding Q, Grammer JR, Nelson MA, et al: p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. J Biol Chem 280: 6802-6815, 2005. (Pubitemid 40341235)
13. Eaton SA, Funnell AP, Sue N, et al: A network of Kruppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. J Biol Chem 283: 26937-26947, 2008.
14. Wang X, Zheng M, Liu G, et al: Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res 67: 7184-7193, 2007. (Pubitemid 47206546)
15. Wang X and Zhao J: KLF8 transcription factor participates in oncogenic transformation. Oncogene 26: 456-461, 2007. (Pubitemid 46122835)
16. Imyanitov EN and Moiseyenko VM: Molecular-based choice of cancer therapy: realities and expectations. Clin Chim Acta 379: 1-13, 2007. (Pubitemid 46366983)
17. Masiero M, Nardo G, Indraccolo S, et al: RNA interference: implications for cancer treatment. Mol Aspects Med 28: 143-166, 2007.
18. Tschoep K, Kohlmann A, Schlemmer M, et al: Gene expression profiling in sarcomas. Crit Rev Oncol Hematol 63: 111-124, 2007. (Pubitemid 46990915)
19. Elbashir SM, Harborth J, Lendeckel W, et al: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498, 2001. (Pubitemid 32494397)
20. McManus MT and Sharp PA: Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 3: 737-747, 2002.
21. Mandriota SJ, Jussila L, Jeltsch M, et al: Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 20: 672-682, 2001. (Pubitemid 32167632)
22. Padera TP, Kadambi A, di Tomaso E, et al: Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296: 1883-1886, 2002. (Pubitemid 34596277)
23. Rocchi P, Jugpal P, So A, et al: Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro. BJU Int 98: 1082-1089, 2006. (Pubitemid 44536463)