Adverse effects of hyperlipidemia on bone regeneration and strength

Journal of Bone and Mineral Research

Volumn 27, Issue 2, 2012, Pages 309-318

  Pirih, Flavia ^a   Lu, Jinxiu ^b   Ye, Fei ^b   Bezouglaia, Olga ^a   Atti, Elisa ^a   Ascenzi, Maria Grazia ^a   Tetradis, Sotirios ^a   Demer, Linda ^b,c   Aghaloo, Tara ^a   Tintut, Yin ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

HYPERLIPIDEMIA; OSTEOPOROSIS; PARATHYROID HORMONE; REGENERATION

Indexed keywords

CALCIUM; PARATHYROID HORMONE; PHOSPHORUS; PROCOLLAGEN C PROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE BOWING; BONE REGENERATION; BONE REMODELING; BONE STRENGTH; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; CORTICAL BONE; FEMUR; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIPID DIET; LIPID OXIDATION; MALE; MECHANICAL TORSION; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; POROSITY; SKULL; SKULL DEFECT;

EID: 84862968185     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.541     Document Type: Article

References (48)

1. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM,. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol. 1996; 16 (7): 831-42. (Pubitemid 26234980)
2. Tintut Y, Morony S, Demer LL,. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol. 2004; 24 (2): e6-10.
3. Brodeur MR, Brissette L, Falstrault L, Ouellet P, Moreau R,. Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells. Free Radic Biol Med. 2008; 44 (4): 506-17. (Pubitemid 351181262)
4. Bilezikian JP, Davidson M, Hendrix S, Liu L, Louie M,. Co-morbidity of decreased bone mineral density (BMD) and increased cholesterol levels among women aged 65 years and older: results from NHANES III. ASBMR 27th Annu Meet. 2005; SU130.
5. Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, Park KS, Choi JS,. Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int. 2005; 16 (12): 1975-81.
6. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X,. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006; 83 (1): 146-54. (Pubitemid 44699248)
7. Nuzzo V, de Milita AM, Ferraro T, Monaco A, Florio E, Miano P, Montemarano E, Zuccoli A, de Terlizzi F,. Analysis of skeletal status by quantitative ultrasonometry in a cohort of postmenopausal women with high blood cholesterol without documented osteoporosis. Ultrasound Med Biol. 2009; 35 (5): 717-22.
8. Tanko LB, Bagger YZ, Christiansen C,. Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women. Calcif Tissue Int. 2003; 73 (1): 15-20. (Pubitemid 37022074)
9. Wu S, De Luca F,. Role of cholesterol in the regulation of growth plate chondrogenesis and longitudinal bone growth. J Biol Chem. 2004; 279 (6): 4642-7. (Pubitemid 38199056)
10. Lekamwasam S, Weerarathna T, Rodrigo M, Arachchi WK, Munidasa D,. Osteoporosis and cardiovascular risk among premenopausal women in Sri Lanka. J Clin Densitom. 2009; 12 (2): 245-50.
11. Hirasawa H, Tanaka S, Sakai A, Tsutsui M, Shimokawa H, Miyata H, Moriwaki S, Niida S, Ito M, Nakamura T,. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res. 2007; 22 (7): 1020-30. (Pubitemid 351339724)
12. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL,. Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res. 2001; 16: 182-8. (Pubitemid 32046204)
13. Turek JJ, Watkins BA, Schoenlein IA, Allen KG, Hayek MG, Aldrich CG,. Oxidized lipid depresses canine growth, immune function, and bone formation. J Nutr Biochem. 2003; 14 (1): 24-31. (Pubitemid 36143748)
14. Saarinen A, Saukkonen T, Kivela T, Lahtinen U, Laine C, Somer M, Toiviainen-Salo S, Cole WG, Lehesjoki AE, Makitie O,. Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. Clin Endocrinol (Oxf). 2010; 72 (4): 481-8.
15. Laurila A, Cole SP, Merat S, Obonyo M, Palinski W, Fierer J, Witztum JL,. High-fat, high-cholesterol diet increases the incidence of gastritis in LDL receptor-negative mice. Arterioscler Thromb Vasc Biol. 2001; 21 (6): 991-6. (Pubitemid 34168658)
16. Navab M, Hama SY, Cooke CJ, Anantharamaiah GM, Chaddha M, Jin L, Subbanagounder G, Faull KF, Reddy ST, Miller NE, Fogelman AM,. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. J Lipid Res. 2000; 1; 41 (9): 1481-94.
17. Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL,. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009; 284 (40): 27438-48.
18. Mody N, Parhami F, Sarafian TA, Demer LL,. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med. 2001; 31 (4): 509-19. (Pubitemid 32728438)
19. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL,. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol. 1997; 17 (4): 680-7. (Pubitemid 27169128)
20. Huang MS, Morony S, Lu J, Zhang Z, Bezouglaia O, Tseng W, Tetradis S, Demer LL, Tintut Y,. Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts. J Biol Chem. 2007; 282 (29): 21237-43. (Pubitemid 47099940)
21. Parhami F, Fang ZT, Fogelman AM, Andalibi A, Territo MC, Berliner JA,. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J Clin Invest. 1993; 92 (1): 471-8. (Pubitemid 23209031)
22. Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL,. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002; 277 (16): 14221-6. (Pubitemid 34968036)
23. Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y,. Hyperlipidemia impairs osteoanabolic effects of PTH. J Bone Miner Res. 2008; 23 (10): 1672-9.
24. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y,. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res. 2011; 26 (6): 1197-206.
25. Cowan CM, Shi YY, Aalami OO, Chou YF, Mari C, Thomas R, Quarto N, Contag CH, Wu B, Longaker MT,. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol. 2004; 22 (5): 560-7. (Pubitemid 38585908)
26. Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S,. SHED repair critical-size calvarial defects in mice. Oral Dis. 2008; 14 (5): 428-34. (Pubitemid 351841717)
27. Bischoff DS, Sakamoto T, Ishida K, Makhijani NS, Gruber HE, Yamaguchi DT,. CXC receptor knockout mice: characterization of skeletal features and membranous bone healing in the adult mouse. Bone. 2011; 48 (2): 267-74.
28. Huang MS, Sage AP, Lu J, Demer LL, Tintut Y,. Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification. Biochem Biophys Res Commun. 2008; 374 (3): 553-8.
29. Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL,. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation. 2008; 117 (3): 411-20.
30. Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E,. Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. Eur Heart J. 2010; 31 (16): 1975-84.
31. Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF,. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem. 1998; 273 (46): 30427-34. (Pubitemid 28545516)
32. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D,. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002; 106 (16): 2067-72. (Pubitemid 35192812)
33. Yan SF, Ramasamy R, Naka Y, Schmidt AM,. Glycation, inflammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res. 2003; 93 (12): 1159-69. (Pubitemid 37543056)
34. Morgantini C, Imaizumi S, Grijalva V, Navab M, Fogelman AM, Reddy ST,. Apolipoprotein A-I mimetic peptides prevent atherosclerosis development and reduce plaque inflammation in a murine model of diabetes. Diabetes. 2010; 59 (12): 3223-8.
35. Kroll MH,. Evaluating interference caused by lipemia. Clin Chem. 2004; 50 (11): 1968-9. (Pubitemid 39425829)
36. Koh AJ, Beecher CA, Rosol TJ, McCauley LK,. 3′,5′-Cyclic adenosine monophosphate activation in osteoblastic cells: effects on parathyroid hormone-1 receptors and osteoblastic differentiation in vitro. Endocrinology. 1999; 140 (7): 3154-62. (Pubitemid 30650631)
37. Elis S, Courtland HW, Wu Y, Fritton JC, Sun H, Rosen CJ, Yakar S,. Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact. J Bone Miner Res. 2010; 25 (9): 2051-8.
38. Schoppet M, Sattler AM, Schaefer JR, Herzum M, Maisch B, Hofbauer LC,. Increased osteoprotegerin serum levels in men with coronary artery disease. J Clin Endocrinol Metab. 2003; 88 (3): 1024-8. (Pubitemid 36337751)
39. Schoppet M, Schaefer JR, Hofbauer LC,. Low serum levels of soluble RANK ligand are associated with the presence of coronary artery disease in men. Circulation. 2003; 107 (11): e76 author reply e76.
40. Hemingway F, Taylor R, Knowles HJ, Athanasou NA,. RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II. Bone. 2011; 48 (4): 938-44.
41. Derfoul A, Carlberg AL, Tuan RS, Hall DJ,. Differential regulation of osteogenic marker gene expression by Wnt-3a in embryonic mesenchymal multipotential progenitor cells. Differentiation. 2004; 72 (5): 209-23. (Pubitemid 41702130)
42. Semenov M, Tamai K, He X,. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem. 2005; 280 (29): 26770-5. (Pubitemid 41040710)
43. Meunier P, Aaron J, Edouard C, Vignon G,. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res. 1971; 80: 147-54.
44. Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M, Demer LL,. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res. 1999; 14 (12): 2067-78. (Pubitemid 30026956)
45. Getz GS, Reardon CA,. Diet and murine atherosclerosis. Arterioscler Thromb Vasc Biol. 2006; 26 (2): 242-9. (Pubitemid 43732181)
46. Vergnes L, Phan J, Strauss M, Tafuri S, Reue K,. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem. 2003; 278 (44): 42774-84. (Pubitemid 37345887)
47. Yesilaltay A, Daniels K, Pal R, Krieger M, Kocher O,. Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice. PLoS One. 2009; 4 (12): e8103.
48. Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK,. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest. 1994; 93 (5): 1885-93. (Pubitemid 24143065)