Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity

Toxicological Sciences

Volumn 125, Issue 2, 2012, Pages 335-344

  Yang, Xi ^a   Greenhaw, James ^a   Shi, Qiang ^a   Su, Zhenqiang ^b   Qian, Feng ^b   Davis, Kelly ^c   Mendrick, Donna L ^a   Salminen, William F ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b ICF INTERNATIONAL   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Biomarkers; Hepatotoxicity; microRNA; Urinary

Indexed keywords

ALANINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; MICRORNA; PARACETAMOL; PENICILLIN G;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CLUSTER ANALYSIS; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE TARGETING; HISTOPATHOLOGY; LIVER LEVEL; LIVER NECROSIS; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; NONHUMAN; RAT; URINALYSIS; URINE LEVEL;

ANIMALIA; RATTUS;

EID: 84862954550     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr321     Document Type: Article

References (44)

1. Bartels, C. L., and Tsongalis, G. J. (2009). MicroRNAs: Novel biomarkers for human cancer. Clin. Chem. 55, 623-631.
2. Bessems, J. G. M., and Vermeulen, N. P. E. (2001). Paracetamol (Acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches. Crit. Rev. Toxicol. 31, 55-138.
3. Bushel, P. R., Heinloth, A. N., Li, J., Huang, L., Chou, J. W., Boorman, G. A., Malarkey, D. E., Houle, C. D., Ward, S. M., Wilson, R. E., et al. (2007). Blood gene expression signatures predict exposure levels. Proc. Natl. Acad. Sci. U.S.A. 104, 18211-18216.
4. Dunnick, J. K., and Elwell, M. R. (1989). Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, [alpha]-methyldopa, penicillin VK and propantheline bromide in rats and mice. Toxicology 56, 123-136.
5. Etheridge, A., Lee, I., Hood, L., Galas, D., and Wang, K. (2011). Extracellular microRNA: A new source of biomarkers. Mutat. Res. 717, 85-90.
6. Fang, H., Harris, S., Su, Z., Chen, M., Qian, F., Shi, L., Perkins, R., and Tong, W. (2009). ArrayTrack: An FDA and public genomic tool. Methods Mol. Biol. 563, 379-398
7. Fannin, R. D., Russo, M., O'Connell, T. M., Gerrish, K., Winnike, J. H., Macdonald, J., Newton, J., Malik, S., Sieber, S. O., Parker, J., et al. (2010). Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation. Hepatology 51, 227-236.
8. Friedman, J. M., and Jones, P. A. (2009). MicroRNAs: Critical mediators of differentiation, development and disease. Swiss Med. Wkly. 139, 466-472.
9. Friedman, R. C., Farh, K. K., Burge, C. B., and Bartel, D. P. (2009). Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92-105.
10. Fukushima, T., Hamada, Y., Yamada, H., and Horii, I. (2007). Changes of micro-RNA expression in rat liver treated by acetaminophen or carbon tetrachloride-regulating role of micro-RNA for RNA expression. J. Toxicol. Sci. 32, 401-409.
11. He, L., and Hannon, G. J. (2004). MicroRNAs: Small RNAs with a big role in gene regulation. Nat. Rev. Genet. 5, 522-531.
12. Heinloth, A. N., Irwin, R. D., Boorman, G. A., Nettesheim, P., Fannin, R. D., Sieber, S. O., Snell, M. L., Tucker, C. J., Li, L., Travlos, G. S., et al. (2004). Gene expression prolfiing of rat livers reveals indicators of potential adverse effects. Toxicol. Sci. 80, 193-202.
13. Khan, M. R., Rizvi, W., Khan, G. N., Khan, R. A., and Shaheen, S. (2009). Carbon tetrachloride-induced nephrotoxicity in rats: Protective role of Digera muricata. J. Ethnopharmacol. 122, 91-99.
14. Kim, W. R., Flamm, S. L., Di Bisceglie, A. M., and Bodenheimer, H. C. (2008). Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology 47, 1363-1370.
15. Lagos-Quintana, M., Rauhut, R., Meyer, J., Borkhardt, A., and Tuschl, T. (2003). New microRNAs from mouse and human. RNA (N.Y.) 9, 175-179.
16. Laterza, O. F., Lim, L., Garrett-Engele, P. W., Vlasakova, K., Muniappa, N., Tanaka, W. K., Johnson, J. M., Sina, J. F., Fare, T. L., Sistare, F. D., et al. (2009). Plasma microRNAs as sensitive and specific biomarkers of tissue injury. Clin. Chem. 55, 1977-1983.
17. Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., Bartel, D. P., and Burge, C. B. (2003). Prediction of mammalian microRNA targets. Cell 115, 787-798.
18. Lobenhofer, E. K., Auman, J. T., Blackshear, P. E., Boorman, G. A., Bushel, P. R., Cunningham, M. L., Fostel, J. M., Gerrish, K., Heinloth, A. N., Irwin, R. D., et al. (2008). Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biol. 9, R100.
19. Luo, H., Zhang, H., Zhang, Z., Zhang, X., Ning, B., Guo, J., Nie, N., Liu, B., and Wu, X. (2009). Down regulated miR-9 and miR-433 in human gastric carcinoma. J. Exp. Clin. Cancer Res. 28, 82.
20. Ma, F., Liu, X., Li, D., Wang, P., Li, N., Lu, L., and Cao, X. (2010). MicroRNA-466l upregulates IL-10 expression in TLR-triggered macro-phages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J. Immunol. 184, 6053-6059.
21. Maziasz, T. J., Liu, J., Madhu, C., and Klaassen, C. D. (1991). The differential effects of hepatotoxicants on the sulfation pathway in rats. Toxicol. Appl. Pharmacol. 110, 365-373.
22. Mendrick, D. L. (2011). Transcriptional profiling to identify biomarkers of disease and drug response. Pharmacogenomics 12, 235-249.
23. Mendrick, D. L., and Schnackenberg, L. (2009). Genomic and metabolomic advances in the identification of disease and adverse event biomarkers. Biomark. Med. 3, 605-615.
24. Nathwani, R. A., Pais, S., Reynolds, T. B., and Kaplowitz, N. (2005). Serum alanine aminotransferase in skeletal muscle diseases. Hepatology 41, 380-382.
25. Newton, J. F., Bailie, M. B., and Hook, J. B. (1983). Acetaminophen nephrotoxicity in the rat. Renal metabolic activation in vitro. Toxicol. Appl. Pharmacol. 70, 433-444.
26. Ozturk, F., Ucar, M., Ozturk, I. C., Vardi, N., and Batcioglu, K. (2003). Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology 62, 353-356.
27. Shah, A. A., Leidinger, P., Blin, N., and Meese, E. (2010). miRNA: Small molecules as potential novel biomarkers in cancer. Curr. Med. Chem. 17, 4427-4432.
28. Shi, Q., Hong, H., Senior, J., and Tong, W. (2010). Biomarkers for drug-induced liver injury. Expert Rev. Gastroenterol. Hepatol. 4, 225-234.
29. Song, G., and Wang, L. (2008). miR-433 and miR-127 arise from independent overlapping primary transcripts encoded by the miR-433-127 locus. PLoS One 3, e3574.
30. Stine, J. G., and Lewis, J. H. (2011). Drug-induced liver injury: A summary of recent advances. Expert Opin. Drug Metab. Toxicol. 7, 875-890.
31. Takahashi, Y., Forrest, A. R., Maeno, E., Hashimoto, T. Daub, C. O., and Yasuda, J. (2009). miR-107 and miR-185 can induce cell cycle arrest in human non-small-cell lung cancer cell lines. PLoS One 4, e6677.
32. Taylor, E. L., and Gant, T. W. (2008). Emerging fundamental roles for non-coding RNA species in toxicology. Toxicology 246, 34-39.
33. Thomson, D. W., Bracken, C. P., and Goodall, G. J. (2011). Experimental strategies for microRNA target identification. Nucleic Acids Res. 39, 6845-6853.
34. Vaira, V., Faversani, A., Dohi, T., Montorsi, M., Augello, C., Gatti, S., Coggi, G., Altieri, D. C., and Bosari, S. miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. Oncogene. Forthcoming.
35. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., and Speleman, F. (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, research0034.1-research0034.11.
36. Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L. E., and Galas, D. J. (2009). Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl. Acad. Sci. U.S.A. 106, 4402-4407.
37. Wang, K., Zhang, S., Weber, J., Baxter, D., and Galas, D. J. (2010). Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res. 38, 7248-7259.
38. Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y., How Huang, K., Jen Lee, M., Galas, D. J., and Wang, K. (2010). The microRNA spectrum in 12 body fluids. Clin. Chem. 56, 1733-1741.
39. Wei, J., Xie, L., Taron, M., Rosell, R., and Liu, B. (2010). Epigenetic alterations of tumor marker microRNAs: Towards new cancer therapies. Drug News Perspect. 23, 655-661.
40. Würdinger, T., Tannous, B. A., Saydam, O., Skog, J., Grau, S., Soutschek, J., Weissleder, R., Breakefield, X. O., and Krichevsky, A. M. (2008). miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 14, 382-393.
41. Yang, X., Li, Z., Su, Z., Davis, K., Chen, T., Mendrick, D. L., and Salminen, W. F. (2011). Urinary microRNAs as noninvasive biomarkers for acetaminophen-induced liver injury. J. Postgenom. Drug Biomark. Develop. 1, 101.
42. Yokoi, T., and Nakajima, M. (2011). Toxicological implications of modulation of gene expression by microRNAs. Toxicol. Sci. 123, 1-14.
43. Zhang, Y., Jia, Y., Zheng, R., Guo, Y., Wang, Y., Guo, H., Fei, M., and Sun, S. (2010). Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clin. Chem. 56, 1830-1838.
44. Zidek, N., Hellmann, J., Kramer, P.-J., and Hewitt, P. G. (2007). Acute hepatotoxicity: A predictive model based on focused Illumina microarrays. Toxicol. Sci. 99, 289-302.