A double-blind randomized controlled comparison of apddr-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris

European Journal of Dermatology

Volumn 21, Issue 6, 2011, Pages 959-965

  Lee, Ha Eun ^a   Ko, Joo Yeon ^a   Kim, Young Hoon ^a   Yoo, Seo Rye ^a   Moon, Sang Ho ^a   Kim, Nack In ^b   Park, Chunwook ^c   Kim, Jeong Hwan ^d   Koh, Hyun Ju ^d   Park, Won Seok ^d   Ro, Young Suck ^a  

^a Hanyang University College of Medicine   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

^c Hallym University College of Medicine   (South Korea)

^d AmorePacific Corporation   (South Korea)

Author keywords

Acne vulgaris; Adapalene; Cosmeceutical; Hexamidine diisethionate; Retinol; Rose extract

Indexed keywords

ACLENE GEL; ADAPALENE; APDDR 0901; COSMETIC; HEXAMIDINE ISETIONATE; PLANT EXTRACT; RETINOL; ROSE EXTRACT; UNCLASSIFIED DRUG;

ACNE VULGARIS; ADOLESCENT; ADULT; ARTICLE; BURNING SENSATION; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD TO MODERATE ACNE VULGARIS; MULTICENTER STUDY; PRICKING; RANDOMIZED CONTROLLED TRIAL; ROSE; SCALING; SELF EVALUATION; SIDE EFFECT; SKIN IRRITATION;

ACNE VULGARIS; ADOLESCENT; ADULT; BENZAMIDINES; COSMETICS; DERMATOLOGIC AGENTS; DOUBLE-BLIND METHOD; FEMALE; GELS; HUMANS; MALE; NAPHTHALENES; PLANT EXTRACTS; TREATMENT OUTCOME; VITAMIN A; YOUNG ADULT;

EID: 84862942905     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2011.1546     Document Type: Article

References (15)

1. James WD. Clinical practice. Acne. N Engl J Med 2005; 352: 1463-72.
2. Ascenso A, Marques HC. Acne in the adult. Mini Rev Med Chem 2009; 9: 1-10.
3. Thielitz A, Gollnick H. Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol 2008; 9: 369-81.
4. Thielitz A, Krautheim A, Gollnick H. Update in retinoid therapy of acne. Dermatol Ther 2006; 19: 272-9.
5. Michel G, Truquet M, Mondain J, et al. Comparison of in vivo antibacterial activity of hydro-alcoholic solutions of hexamidine and chlorhexidine. J Int Med Res 1986; 14: 205-9.
6. Kligman A. Cosmeceuticals: do we need a new category? In: Elsner P, Maiback H, eds. Cosmeceuticals. New York: Marcel Dekker, 2000: 1.
7. Draelos ZD. The cosmeceutical realm. Clin Dermatol 2008; 26: 627-32.
8. Gao XH, Zhang L, Wei H, et al. Efficacy and safety of innovative cosmeceuticals. Clin Dermatol 2008; 26: 367-74.
9. Dawson MI, Hobbs PD. The synthetic chemistry of retinoids. In: Sporn MB, Roberts AB, Goodman DS, eds. The Retinoids Biology, Chemistry and Medicine. 3rd ed. New York: Raven Press, 1994: 5-178.
10. Bernard BA. Adapalene, a new chemical entity with retinoid activity. Skin Pharmacol 1993; 6: 61-9.
11. Weinstein GD. Safety, efficacy and duration of therapeutic effect of tazarotene used in the treatment of plaque psoriasis. Br J Dermatol 1996; 135: 32-6.
12. Varani J, Warner RL, Gharaee-Kermani M, et al. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J Invest Dermatol 2000; 114: 480-6.
13. Babamiri K, Nassab R. Cosmeceuticals: the evidence behind the retinoids. Aesthet Surg J 2010; 30: 74-7.
14. Manela-Azulay M, Bagatin E. Cosmeceuticals vitamins. Clin Dermatol 2009; 27: 469-74.
15. Becker L. Final report on the safety assessment of hexamidine and hexamidine diisethionate. Int J Toxicol 2007; 26(Suppl. 3): 79-88.