Functional role of PPARδ in corneal epithelial wound healing

American Journal of Pathology

Volumn 180, Issue 2, 2012, Pages 583-598

  Nakamura, Yoshikuni ^a   Nakamura, Takahiro ^b,c   Tarui, Takeshi ^a   Inoue, Jun ^a   Kinoshita, Shigeru ^c  

^a SENJU PHARMACEUTICAL CO LTD   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; GAMMA INTERFERON; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA LIMBUS; DNA FRAGMENTATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; KERATITIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; BURNS, CHEMICAL; CELL DEATH; CELLS, CULTURED; CORNEA; CYTOKINES; EPITHELIUM, CORNEAL; EYE BURNS; HUMANS; KERATITIS; MALE; PPAR GAMMA; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM COMPOUNDS; THIAZOLES; UP-REGULATION; WOUND HEALING;

EID: 84862932664     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.10.006     Document Type: Article

References (36)

1. I. Issemann, S. Green Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 1990 645 650
2. C. Dreyer, G. Krey, H. Keller, F. Givel, G. Helftenbein, W. Wahli Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors Cell 68 1992 879 887
3. L. Michalik, J. Auwerx, J.P. Berger, V.K. Chatterjee, C.K. Glass, F.J. Gonzalez, P.A. Grimaldi, T. Kadowaki, M.A. Lazar, S. O'Rahilly, C.N. Palmer, J. Plutzky, J.K. Reddy, B.M. Spiegelman, B. Staels, W. Wahli International Union of Pharmacology, LXI: peroxisome proliferator-activated receptors Pharmacol Rev 58 2006 726 741
4. L. Michalik, B. Desvergne, N.S. Tan, S. Basu-Modak, P. Escher, J. Rieusset, J.M. Peters, G. Kaya, F.J. Gonzalez, J. Zakany, D. Metzger, P. Chambon, D. Duboule, W. Wahli Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice J Cell Biol 154 2001 799 814
5. N. Di-Po, N.S. Tan, L. Michalik, W. Wahli, B. Desvergne Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway Mol Cell 10 2002 721 733
6. N. Di-Po, L. Michalik, N.S. Tan, B. Desvergne, W. Wahli The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing J Steroid Biochem Mol Biol 85 2003 257 265
7. K. Tsuji, S. Mitsutake, U. Yokose, M. Sugiura, T. Kohama, Y. Igarashi Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes FEBS J 275 2008 3815 3826
8. D.J. Kim, M.T. Bility, A.N. Billin, T.M. Willson, F.J. Gonzalez, J.M. Peters PPARbeta/delta selectively induces differentiation and inhibits cell proliferation Cell Death Differ 13 2006 53 60
9. M. Schmuth, C.M. Haqq, W.J. Cairns, J.C. Holder, S. Dorsam, S. Chang, P. Lau, A.J. Fowler, G. Chuang, A.H. Moser, B.E. Brown, M. Mao-Qiang, Y. Uchida, K. Schoonjans, J. Auwerx, P. Chambon, T.M. Willson, P.M. Elias, K.R. Feingold Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes J Invest Dermatol 122 2004 971 983
10. M.Q. Man, G.D. Barish, M. Schmuth, D. Crumrine, Y. Barak, S. Chang, Y. Jiang, R.M. Evans, P.M. Elias, K.R. Feingold Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation J Invest Dermatol 128 2008 370 377
11. N.S. Tan, G. Icre, A. Montagner, B. Bordier-ten-Heggeler, W. Wahli, L. Michalik The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration Mol Cell Biol 27 2007 7161 7175
12. S.A. Ham, H.J. Kim, H.J. Kim, E.S. Kang, S.Y. Eun, G.H. Kim, M.H. Park, I.S. Woo, H.J. Kim, K.C. Chang, J.H. Lee, H.G. Seo PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins J Cell Mol Med 14 2010 1747 1759
13. N.S. Tan, L. Michalik, N. Noy, R. Yasmin, C. Pacot, M. Heim, B. Flhmann, B. Desvergne, W. Wahli Critical roles of PPAR beta/delta in keratinocyte response to inflammation Genes Dev 15 2001 3263 3277
14. S.C. Pflugfelder, S.L. Maskin, B. Anderson, J. Chodosh, E.J. Holland, C.S. De Paiva, S.P. Bartels, T. Micuda, H.M. Proskin, R. Vogel A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance Am J Ophthalmol 138 2004 444 457
15. K. Gndz, O. Ozdemir Topical cyclosporin treatment of keratoconjunctivitis sicca in secondary Sjgren's syndrome Acta Ophthalmol (Copenh) 72 1994 438 442
16. A.H. El-Shazly, A.A. El-Gohary, L.H. El-Shazly, G.G. El-Hossary Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits Acta Pharm 58 2008 163 173
17. H. Urashima, T. Okamoto, Y. Takeji, H. Shinohara, S. Fujisawa Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo model Cornea 23 2004 613 619
18. J. Tauber, W.F. Davitt, J.E. Bokosky, K.K. Nichols, B.R. Yerxa, A.E. Schaberg, L.M. LaVange, M.C. Mills-Wilson, D.J. Kellerman Double-masked, placebo-controlled safety and efficacy trial of diquafosol tetrasodium (INS365) ophthalmic solution for the treatment of dry eye Cornea 23 2004 784 792
19. D.A. Sullivan, B.D. Sullivan, J.E. Evans, F. Schirra, H. Yamagami, M. Liu, S.M. Richards, T. Suzuki, D.A. Schaumberg, R.M. Sullivan, M.R. Dana Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye Ann N Y Acad Sci 966 2002 211 222
20. G. Schultz, N. Chegini, M. Grant, P. Khaw, S. MacKay Effects of growth factors on corneal wound healing Acta Ophthalmol Suppl 202 1992 60 66
21. P.I. Condon, C.G. McEwen, M. Wright, G. Mackintosh, R.J. Prescott, C. McDonald Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome Br J Ophthalmol 83 1999 1121 1124
22. T. Nishida, S. Nakagawa, R. Manabe Clinical evaluation of fibronectin eyedrops on epithelial disorders after herpetic keratitis Ophthalmology 92 1985 213 216
23. G. Sosne, P. Qiu, M. Kurpakus-Wheater Thymosin beta 4: a novel corneal wound healing and anti-inflammatory agent Clin Ophthalmol 1 2007 201 207
24. M.S. Cortina, J. HE, N. Li, N.G. Bazan, H.E. Bazan Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA Invest Ophthalmol Vis Sci 51 2010 804 810
25. N. Yamada, R. Matsuda, N. Morishige, R. Yanai, T.I. Chikama, T. Nishida, T. Ishimitsu, A. Kamiya Open clinical study of eye-drops containing tetrapeptides derived from substance P and insulin-like growth factor-1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy Br J Ophthalmol 92 2008 896 900
26. K. Watanabe, S. Nakagawa, T. Nishida Chemotactic and haptotactic activities of fibronectin for cultured rabbit corneal epithelial cells Invest Ophthalmol Vis Sci 29 1988 572 577
27. M.L. Sznaidman, C.D. Haffner, P.R. Maloney, A. Fivush, E. Chao, D. Goreham, M.L. Sierra, C. LeGrumelec, H.E. Xu, V.G. Montana, M.H. Lambert, T.M. Willson, W.R. Oliver Jr, D.D. Sternbach Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta): synthesis and biological activity Bioorg Med Chem Lett 13 2003 1517 1521
28. A.D. Burdick, M.T. Bility, E.E. Girroir, A.N. Billin, T.M. Willson, F.J. Gonzalez, J.M. Peters Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes Cell Signal 19 2007 1163 1171
29. M. Romanowska, N. al Yacoub, H. Seidel, S. Donandt, H. Gerken, S. Phillip, N. Haritonova, M. Artuc, S. Schweiger, W. Sterry, J. Foerster PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor J Invest Dermatol 128 2008 110 124
30. R. Mller, M. Rieck, S. Mller-Brsselbach Regulation of cell proliferation and differentiation by PPARbeta/delta PPAR Res 2008 2008 614852
31. Q. Li, K. Fukuda, Y. Lu, Y. Nakamura, T. Chikama, N. Kumagai, T. Nishida Enhancement by neutrophils of collagen degradation by corneal fibroblasts J Leukoc Biol 4 2003 412 419
32. Z. Zhang, Z. Pan, F. Zhang, P.S. Reinach Pparβ antagonist mediates increases in human corneal epithelial cell migration through P38 Mapk activation Assoc Res Vision Ophthalmol (ARVO) 2010
33. C. Sotozono, J. He, Y. Matsumoto, M. Kita, J. Imanishi, S. Kinoshita Cytokine expression in the alkali-burned cornea Curr Eye Res 16 1997 670 676
34. S. Yeh, X.J. Song, W. Farley, D.Q. Li, M.E. Stern, S.C. Pflugfelder Apoptosis of ocular surface cells in experimentally induced dry eye Invest Ophthalmol Vis Sci 44 2003 124 129
35. S. Nakamura, M. Shibuya, Y. Saito, H. Nakashima, F. Saito, A. Higuchi, K. Tsubota Protective effect of D-beta-hydroxybutyrate on corneal epithelia in dry eye conditions through suppression of apoptosis Invest Ophthalmol Vis Sci 44 2003 4682 4688
36. W. Chen, X. Zhang, J. Zhang, J. Chen, S. Wang, Q. Wang, J. Qu A murine model of dry eye induced by an intelligently controlled environmental system Invest Ophthalmol Vis Sci 49 2008 1386 1391