Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome

Journal of Experimental Medicine

Volumn 208, Issue 13, 2011, Pages 2607-2613

  Ouchi, Takeshi ^a   Kubo, Akiharu ^a   Yokouchi, Mariko ^a   Adachi, Takeya ^a   Kobayashi, Tetsuro ^a   Kitashima, Daniela Y ^a   Fujii, Hideki ^a   Clausen, Björn E ^b   Koyasu, Shigeo ^a   Amagai, Masayuki ^a   Nagao, Keisuke ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; EXFOLIATIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 ANTIBODY; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE SEVERITY; EPIDERMIS; HUMORAL IMMUNITY; IMMUNITY; IMMUNIZATION; LANGERHANS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCAL SCALDED SKIN SYNDROME; TIGHT JUNCTION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, NEUTRALIZING; ANTIBODY FORMATION; ANTIGENS, BACTERIAL; DESMOGLEIN 1; DISEASE MODELS, ANIMAL; EPIDERMIS; EXFOLIATINS; IMMUNITY, HUMORAL; IMMUNOGLOBULIN G; LANGERHANS CELLS; MICE; MICE, TRANSGENIC; STAPHYLOCOCCAL SCALDED SKIN SYNDROME; STAPHYLOCOCCUS AUREUS; TIGHT JUNCTIONS;

EID: 84862908998     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20111718     Document Type: Article

References (28)

1. Allan, R.S., C.M. Smith, G.T. Belz, A.L. van Lint, L.M. Wakim, W.R. Heath, and F.R. Carbone. 2003. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science. 301:1925-1928. http://dx.doi.org/10.1126/science.1087576.
2. Amagai, M., N. Matsuyoshi, Z.H. Wang, C. Andl, and J.R. Stanley. 2000. Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nat. Med. 6:1275-1277. http://dx.doi.org/10.1038/81385.
3. Bennett, C.L., E. van Rijn, S. Jung, K. Inaba, R.M. Steinman, M.L. Kapsenberg, and B.E. Clausen. 2005. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169:569-576. http://dx.doi.org/10.1083/jcb.200501071.
4. Bennett, C.L., M. Noordegraaf, C.A. Martina, and B.E. Clausen. 2007. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J. Immunol. 179:6830-6835.
5. Bursch, L.S., L. Wang, B. Igyarto, A. Kissenpfennig, B. Malissen, D.H. Kaplan, and K.A. Hogquist. 2007. Identification of a novel population of Langerin+ dendritic cells. J. Exp. Med. 204:3147-3156. http://dx.doi .org/10.1084/jem.20071966.
6. Ginhoux, F., M.P. Collin, M. Bogunovic, M. Abel, M. Leboeuf, J. Helft, J. Ochando, A. Kissenpfennig, B. Malissen, M. Grisotto, et al. 2007. Bloodderived dermal langerin+ dendritic cells survey the skin in the steady state. J. Exp. Med. 204:3133-3146. http://dx.doi.org/10.1084/jem.20071733.
7. Hanakawa, Y., N.M. Schechter, C. Lin, L. Garza, H. Li, T. Yamaguchi, Y. Fudaba, K. Nishifuji, M. Sugai, M. Amagai, and J.R. Stanley. 2002. Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J. Clin. Invest. 110:53-60.
8. Ishii, K., M. Amagai, R.P. Hall, T. Hashimoto, A. Takayanagi, S. Gamou, N. Shimizu, and T. Nishikawa. 1997. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J. Immunol. 159:2010-2017.
9. Ishii, K., C. Lin, D.L. Siegel, and J.R. Stanley. 2008. Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J. Invest. Dermatol. 128:939-948. http://dx.doi.org/10.1038/sj.jid.5701132.
10. Itoh, M., S. Yonemura, A. Nagafuchi, S. Tsukita, and S. Tsukita. 1991. A 220-kD undercoat-constitutive protein: its specific localization at cadherinbased cell-cell adhesion sites. J. Cell Biol. 115:1449-1462. http://dx.doi .org/10.1083/jcb.115.5.1449.
11. Kaplan, D.H., M.C. Jenison, S. Saeland, W.D. Shlomchik, and M.J. Shlomchik. 2005. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity. 23:611-620. http://dx.doi .org/10.1016/j.immuni.2005.10.008.
12. Kautz-Neu, K., M. Noordegraaf, S. Dinges, C.L. Bennett, D. John, B.E. Clausen, and E. von Stebut. 2011. Langerhans cells are negative regulators of the anti-Leishmania response. J. Exp. Med. 208:885-891. http://dx.doi.org/10.1084/jem.20102318.
13. Kissenpfennig, A., S. Henri, B. Dubois, C. Laplace-Builhé, P. Perrin, N. Romani, C.H. Tripp, P. Douillard, L. Leserman, D. Kaiserlian, et al. 2005. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity. 22:643-654. http://dx.doi.org/10.1016/j .immuni.2005.04.004.
14. Kubo, A., K. Nagao, M. Yokouchi, H. Sasaki, and M. Amagai. 2009. External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J. Exp. Med. 206:2937-2946. http://dx.doi.org/10.1084/jem.20091527.
15. Ladhani, S., C.L. Joannou, D.P. Lochrie, R.W. Evans, and S.M. Poston. 1999. Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome. Clin. Microbiol. Rev. 12:224-242.
16. Merad, M., M.G. Manz, H. Karsunky, A. Wagers, W. Peters, I. Charo, I.L. Weissman, J.G. Cyster, and E.G. Engleman. 2002. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3:1135-1141. http://dx.doi.org/10.1038/ni852.
17. Nagao, K., F. Ginhoux, W.W. Leitner, S. Motegi, C.L. Bennett, B.E. Clausen, M. Merad, and M.C. Udey. 2009. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc. Natl. Acad. Sci. USA. 106:3312-3317. http://dx.doi.org/10.1073/pnas.0807126106.
18. Nishioka, K., T. Nakano, N. Hirao, and Y. Asada. 1977a. Staphylococcal scalded skin syndrome I. Purification of exfoliatin and maternal transmission of neutralizing ability against exfoliatin. J. Dermatol. 4: 13-18.
19. Nishioka, K., T. Nakano, N. Hirao, H. Teranishi, and Y. Asada. 1977b. Staphylococcal scalded skin syndrome. II. Serum level of anti exfoliatin and anti alpha-toxin in patients with staphylococcal scalded skin syndrome or bullous impetigo. J. Dermatol. 4:65-68.
20. Noordegraaf, M., V. Flacher, P. Stoitzner, and B.E. Clausen. 2010. Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity. J. Invest. Dermatol. 130:2752-2759. http://dx.doi.org/10.1038/jid.2010.223.
21. Poulin, L.F., S. Henri, B. de Bovis, E. Devilard, A. Kissenpfennig, and B. Malissen. 2007. The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J. Exp. Med. 204:3119-3131. http://dx.doi.org/10.1084/jem.20071724.
22. Prausnitz, M.R., J.A. Mikszta, M. Cormier, and A.K. Andrianov. 2009. Microneedle-based vaccines. Curr. Top. Microbiol. Immunol. 333:369-393. http://dx.doi.org/10.1007/978-3-540-92165-3_18.
23. Schuler, G., and R.M. Steinman. 1985. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161:526-546. http://dx.doi.org/10.1084/jem.161.3.526.
24. Stanley, J.R., and M. Amagai. 2006. Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. N. Engl. J. Med. 355:1800-1810. http://dx.doi.org/10.1056/NEJMra061111.
25. Vermeer, P.D., L.A. Einwalter, T.O. Moninger, T. Rokhlina, J.A. Kern, J. Zabner, and M.J. Welsh. 2003. Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature. 422:322-326. http://dx.doi.org/10.1038/nature01440.
26. Wilson, N.S., and J.A. Villadangos. 2004. Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm. Immunol. Cell Biol. 82:91-98. http://dx.doi.org/10.1111/j.1440-1711.2004.01216.x.
27. Yager, E.J., H.J. Dean, and D.H. Fuller. 2009. Prospects for developing an effective particle-mediated DNA vaccine against influenza. Expert Rev. Vaccines. 8:1205-1220. http://dx.doi.org/10.1586/erv.09.82.
28. Yamasaki, O., T. Yamaguchi, M. Sugai, C. Chapuis-Cellier, F. Arnaud, F. Vandenesch, J. Etienne, and G. Lina. 2005. Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins. J. Clin. Microbiol. 43:1890-1893. http://dx.doi.org/10.1128/JCM.43.4.1890-1893.2005.