Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity

Human Vaccines

Volumn 7, Issue SUPPL., 2011, Pages 191-198

  Farrance, Christine E ^a   Chichester, Jessica A ^a   Musiychuk, Konstantin ^a   Shamloul, Moneim ^a   Rhee, Amy ^a   Manceva, Slobodanka D ^a   Jones, R Mark ^a   Mamedov, Tarlan ^a   Sharma, Satish ^a   Mett, Vadim ^a   Streatfield, Stephen J ^a   Roeffen, Will ^b   Van De Vegte Bolmer, Marga ^b   Sauerwein, Robert W ^b   Wu, Yimin ^c   Muratova, Olga ^c   Miller, Louis ^c   Duffy, Patrick ^c   Sinden, Robert ^d   Yusibov, Vidadi ^a  

^a Fraunhofer USA Inc   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Malaria; Nicotiana benthamiana; Pfs25; Plants; Recombinant vaccine; TBV

Indexed keywords

MALARIA VACCINE; PARASITE ANTIBODY; PARASITE ANTIGEN; PLASMODIUM FALCIPARUM SEXUAL STAGE 25 PROTEIN; PROTEIN P25; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; IMMUNIZATION; IMMUNOGENICITY; INFECTION PREVENTION; MALARIA CONTROL; MALARIA FALCIPARUM; MOSQUITO; MOUSE; NONHUMAN; PARASITE TRANSMISSION; PARASITE VIRULENCE; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM FALCIPARUM; PROTEIN EXPRESSION; REVIEW; TRANSIENT EXPRESSION; TREATMENT DURATION; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, PROTOZOAN; CULICIDAE; DISEASE TRANSMISSION, INFECTIOUS; FEEDING BEHAVIOR; MALARIA VACCINES; MALARIA, FALCIPARUM; MICE; PLANTS, GENETICALLY MODIFIED; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; TOBACCO;

EID: 84862908922     PISSN: 15548600     EISSN: 15548619     Source Type: Journal    
DOI: 10.4161/hv.7.0.14588     Document Type: Review

References (32)

1. Enserink M. Malaria's drug miracle in danger (News article). Science 2010; 138:844-6.
2. Good MF, Kaslow DC, Miller LM. Pathways and strategies for developing a malaria blood-stage vaccine. Annu Rev Immunol 1998; 16:57-87. (Pubitemid 28183359)
3. WHO: http://www.who.int/mediacentre/factsheets/ fs094/en/index.html.
4. Aly ASI, Vaughan AM, Kappe SHI. Malaria parasite development in the mosquito and infection of the mammalian host. Annu Rev Microbiol 2009; 63:195-221.
5. Samuelson J, Banerjee S, Magnelli P, Cui J, Kelleher DJ, Gilmore R. The diversity of dolochol-linked precursors to Asn-linked glycans likely result from secondary loss of sets of glycotransferases. Proc Natl Acad Sci USA 2005; 102:1548-53. (Pubitemid 40209206)
6. Pradel G. Proteins of the malaria parasite sexual stages: expression, function and potential for transmission blocking strategies. Parasitology 2007; 134:1911-29. (Pubitemid 350100446)
7. Barr PJ, Green KM, Gibson HL, Bathurst IC, Quakyi IA, Kaslow DC. Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmissionblocking immunity in experimental animals. J Exp Med 1991; 174:1203-8.
8. Kaslow DC, Bathurst IC, Lensen T, Ponnudurai T, Barr PJ, Keister DB. Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum. Infect Immun 1994; 62:5576-80. (Pubitemid 24365003)
9. Zou L, Miles AP, Wang J, Stowers AW. Expression of malaria transmission-blocking vaccine antigen Pfs25 in Pichia pastoris for use in human clinical trials. Vaccine 2003; 21:1650-7. (Pubitemid 36287596)
10. Wu Y, Przysiecki C, Flanagan E, Bello-Irizarry SN, Ionescu R, Muratova O, et al. Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex. Proc Natl Acad Sci USA 2006; 103:18243-8. (Pubitemid 44871643)
11. Qian F, Wu Y, Muratova O, Zhou H, Dobrescu G, Duggan P, et al. Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: a strategy for enhancing immunogenicity of malaria vaccine candidates. Vaccine 2007; 25:3923-33. (Pubitemid 46616999)
12. Kubler-Kielb J, Majadly F, Wu Y, Narum DL, Guo C, Miller LH, et al. Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25. Proc Natl Acad Sci USA 2007; 104:293-8. (Pubitemid 46068025)
13. Qian F, Rausch KM, Muratova O, Zhou H, Song G, Diouf A, et al. Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders. Vaccine 2008; 26:2521-7.
14. Wu Y, Ellis RD, Shaffer D, Fontes E, Malkin EM, Mahanty S, et al. Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51. PLoS One 2008; 3:2636.
15. Musiychuk K, Stephenson N, Bi H, Farrance CE, Orozovic G, Brodelius M, et al. A launch vector for the production of vaccine antigens in plants. Influenza 2007; 1:19-25.
16. Shoji Y, Bi H, Musiychuk K, Rhee A, Horsey A, Roy G, et al. Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza. Vaccine 2009; 27:1087-92.
17. Kappe SH, Vaughan AM, Boddey JA, Cowman AF. That was then but this is now: malaria research in the time of an eradication agenda. Science 2010; 328:862-6.
18. Butler D. Initiative targets malaria eradication (News article). Nature 2009; 462:19.
19. Vogel G. The 'do unto others' malaria vaccine (News article). Science 2010; 328:847-8.
20. Chichester JA, Musiychuk K, Farrance CE, Mett V, Lyons J, Mett V, et al. A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague. Vaccine 2009; 27:3471-4.
21. Shoji Y, Farrance CE, Bi H, Shamloul M, Green B, Manceva S, et al. Immunogenicity of hemagglutinin from A/Bar-headed Goose/Qinghai/1A/05 and A/ Anhui/1/05 strains of H5N1 influenza viruses produced in Nicotiana benthamiana plants. Vaccine 2009; 27:3467-70.
22. Mett V, Musiychuk K, Bi H, Farrance CE, Horsey A, Ugulava N, et al. A plant-produced influenza sub-unit vaccine protects ferrets against virus challenge. Influenza Other Respi Viruses 2008; 2:33-40.
23. Tsai CW, Duggan PF, Shimp RL Jr, Miller LH, Narum DL. Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris. J Biotechnol 2006; 121:458-70. (Pubitemid 43201924)
24. Matsuoka M, Yamamoto N, Kano-Murakami Y, Tanaka Y, Ozeki Y, Hirano H, et al. Classification and structural comparison of full-length cDNAs for pathogenesis- related proteins. Plant Physiol 1987; 85:942-6.
25. Green BJ, Fujiki M, Mett V, Kaczmarczyk J, Shamloul M, Musiychuk K, et al. Transient protein expression in three Pisum sativum (green pea) varieties. Biotechnol J 2009; 4:1-8.
26. Voinnet O, Rivas S, Mestre P, Baulcombe D. An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus. Plant J 2003; 33:949-56. (Pubitemid 36339384)
27. Edelhoch H. Spectroscopic determination of tryptophan and tyrosine in proteins. Biochemistry 1967; 6:1948-54.
28. Pace CN, Vajdos F, Fee L, Grimsley G, Gray T. How to measure and predict the molar absorption coefficient of a protein. Protein Sci 1995; 4:2411-23.
29. Roeffen WF, Raats JM, Teelen K, Hoet RM, Eling WM, van Venrooij WJ, et al. Recombinant human antibodies specific for the Pfs48/45 protein of the malaria parasite Plasmodium falciparum. J Biol Chem 2001; 276:19807-11.
30. Roeffen W, Geeraedts F, Eling W, Beckers P, Kumar N, Lensen T, et al. Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependent. Infect Immun 1995; 63:467-71.
31. Outchkourov N, Vermunt A, Jansen J, Kaan A, Roeffen W, Teelen K, et al. Epitope analysis of the malaris surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies. J Biol Chem 2007;282:17148-56. (Pubitemid 47093201)
32. William CB. The use of logarithms in the interpretation of certain entomological problems. Ann Appl Biol 1937; 24:404-14.