A clinical trial of xenotransplantation of neonatal pig islets for diabetic patients

Journal of Central South University (Medical Sciences)

Volumn 36, Issue 12, 2011, Pages 1134-1140

  Wang, Wei ^a   Mo, Zhaohui ^a   Ye, Bin ^a   Hu, Pin'an ^a   Liu, Sheng ^a   Yi, Shounan ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

Diabetic patient; Neonatal pig islet; Xenotransplantation

Indexed keywords

C PEPTIDE; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ADULT; ANIMAL; ARTICLE; BLOOD; CLINICAL TRIAL; DOG; EXPERIMENTAL DIABETES MELLITUS; FEMALE; FOLLOW UP; HEPATIC ARTERY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTRAARTERIAL DRUG ADMINISTRATION; MALE; METHODOLOGY; MIDDLE AGED; MOUSE; NEWBORN; NUDE MOUSE; PANCREAS ISLET TRANSPLANTATION; SWINE; XENOGRAFT;

ADOLESCENT; ADULT; ANIMALS; ANIMALS, NEWBORN; C-PEPTIDE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOGS; FEMALE; FOLLOW-UP STUDIES; HEPATIC ARTERY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRA-ARTERIAL; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, NUDE; MIDDLE AGED; SWINE; TRANSPLANTATION, HETEROLOGOUS; YOUNG ADULT;

EID: 84862908706     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2011.12.002     Document Type: Article

References (17)

1. First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials; Changsha, China, The Changsha Communique [J]. Xenotransplantation, 2009, 16 (2) : 61-63.
2. Groth C G, Korsgren O, Tibell A, et al. Transplantation of porcine fetal pancreas to diabetic patients [J]. Lancet, 1994, 344 (19) :1402-1404 (Pubitemid 24365315)
3. Valde's-Gonza'lez R A, Dorantes L M, Garibay G N, et al. Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells : a 4-year study [J]. Eur J Endocrinol, 2005, 153:419427.
4. XIA Huisheng, ZHANG Weijie, JIANG Hanying, et al. Three cases of heterogeneic islet transplantation [J]. Chinese Journal of Organ Transplantation, 1993, 14 (4) :.146-147.
5. Kirchhof N, Shibata S, Martin W, et al. Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection [ J ]. Xenotransplantation, 2004, 11 (5) : 396-407. (Pubitemid 39128209)
6. Bennet W, Sundberg B, Lundgren T, et al. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys : protective effects of sCR 1 and heparin [J]. Transplantation, 2000, 69 (5) : 711-719. (Pubitemid 30174086)
7. Rayat G R, Rajotte R V, Hering B J, et al. In vitro and in vivo expression of Galalpha- (1, 3) Gal on porcine islet cells is age dependentJ]. J Endocrinol, 2003, 177 (1) : 127-135. (Pubitemid 36592593)
8. Martin S I, Wilkinson R, Fishman J A. Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine[J], Virol J, 2006, 3:91-97.
9. Shapiro A M, Lakey J R, Ryan E A, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticid free immunosuppressive regimen[J]. N Engl J Med, 2000, 343 (4) : 230-238. (Pubitemid 30490390)
10. Gaber A O, Chamsuddin A, Fraga D, et al. Insulin independence achieved using the transmesenteri approach to the portal vein for islet transplantation [J]. Transplantation, 2004, 77 (2) : 309-311. (Pubitemid 38155764)
11. Cardona k, Korbutt G S, Milas Z, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways[J]. Nat Med, 2006, 12 (3) : 304-306.
12. Owen R J, Ryan E A, O' Kelly K, et al. Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus : radiologic aspects[ J]. Radiology, 2003, 229 (1) : 165-170. (Pubitemid 37152120)
13. Hirshberg B, Montgomery S, Wysoki MG, et al. Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site[J]. Diabetes, 2002, 51 (7) : 2135-2140. (Pubitemid 34729018)
14. Korbutt G S, Elliott JF, Ao Z, et al. Large scale isolation, growth, and function of porcine neonatal islet Cells[J]. J Clin Invest, 1996, 97 (9) : 2119-2129. (Pubitemid 26143967)
15. Tatsuya K, Korbutt G S, Kobayashi T, et al. Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets[J]. Diabetes, 2005, 54 (4) : 1032-1039. (Pubitemid 40446316)
16. Hering B J, Wijkstrom M, Graham ML, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in : immunosuppressed nonhuman primates [J]. Nat Med, 2006, 12 (3) : 301-303. (Pubitemid 43355076)
17. Gangappa S, Larsen C P. Immunosuppressive protocols for pigto-human islet transplantation lessons from pre-clinical nonhuman primate models [J]. Xenotransplantation, 2008, 15 (2) : 107-1 1 1.