Original Article Anti-oxidant pathways are stimulated by mesenchymal stromal cells in renal repair after ischemic injury

Cytotherapy

Volumn 14, Issue 2, 2012, Pages 162-172

  Liu, Hongyan ^a,b   McTaggart, Steven J ^c   Johnson, David W ^a,d   Gobe, Glenda C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^d PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

Apoptosis; Inflammation; Ischemiareperfusion; Mesenchymal stromal cells; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CREATININE; CYCLINE; EPIDERMAL GROWTH FACTOR; HEME OXYGENASE 1; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN; PROTEIN BAX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL DEATH; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EPITHELIUM CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY TUBULE CELL; MALE; MESENCHYMAL STROMA CELL; MITOSIS; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TISSUE CULTURE; TISSUE REPAIR; WESTERN BLOTTING;

EID: 84862908025     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2011.613927     Document Type: Article

References (40)

1. Kale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. J Clin Invest. 2003; 112:42-9. (Pubitemid 38056374)
2. Lin F, Cordes K, Li L, Hood L, Couser WG, Shankland SJ, et al. Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischaemia-reperfusion injury in mice. J Am Soc Nephrol. 2003;14:1188-99. (Pubitemid 36514661)
3. Herrera MB, Bussolati B, Bruno S, Fonsato V, Romanazzi GM, Camussi G. Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med. 2004;14:1035-41.
4. Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, et al. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol. 2004;15:1794-804. (Pubitemid 38822058)
5. Duffield JS, Bonventre JV. Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int 2005;68:1956-61. (Pubitemid 43117771)
6. Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol. 2005;289:F31-42. (Pubitemid 40863570)
7. Kunter U, Rong S, Djuric Z, Boor P, Muller-Newen G, Yu D, et al. Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. J Am Soc Nephrol. 2006;17:2202-12. (Pubitemid 44141910)
8. Lange C, Togel F, Ittrich H, Clayton F, Nolte-Ernsting C, Zander AR, et al. Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int. 2005;68:1613-17. (Pubitemid 43169906)
9. Cavaglieri RC, Martini D, Sogayar MC, Noronha IL. Mes-enchymal stem cells delivered at the subcapsule of the kidney ameliorate renal disease in the rat remnant kidney model. Transplant Proc. 2009;41:947-51.
10. Zhuo W, Liao L, Xu T, Wu W, Yang S. Mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal dysfunction by improving the anti-oxidant balance of the ischemic kidney. Urol Int. 2011;86:191-6.
11. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mes-enchymal stem cells. Science. 1999;284:143-7. (Pubitemid 29282067)
12. McTaggart SJ, Atkinson K. Mesenchymal stem cells: immu-nobiology and therapeutic potential in kidney disease. Neph-rology (Carlton). 2007;12:44-52.
13. Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M. et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Phys-iol Heart Circ Physiol. 2004;287:H2670-6.
14. Herrera MB, Bussolati B, Bruno S, Morando L, Mauriello-Romanazzi G, Sanavio F, et al. Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury. Kidney Int. 2007;72:430-41. (Pubitemid 47237610)
15. Lin F, Moran A, Igarashi P. Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. J Clin Invest. 2005;115:1756-64. (Pubitemid 40979714)
16. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008;2:84-291.
17. Yew TL, Hung YT, Li HY, Chen HW, Chen LL, Tsai KS, et al. Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38MAPK activation. Cell Transplant. 2010 December 22. [Epub ahead of print]; PMID:21176394.
18. Angoulvant D, Ivanes F, Ferrera R, Matthews PG, Nataf S, Ovize M. Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury. J Heart Lung Transplant. 2011;30:95-102.
19. Kunter U, Rong S, Boor P, Eitner F, Muller-Newen G, Djuric Z, et al. Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomeru-lar adipocytes. J Am Soc Nephrol. 2007;18:1754-64. (Pubitemid 46870312)
20. Zarjou A, Kim J, Traylor AM, Sanders PW, Balla J, Agarwal A, Curtis LM. Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1. Am J Physiol Renal Physiol. 2011;300:F254-62.
21. Brunswig-Spickenheier B, Boche J, Westenfelder C, Peimann F, Gruber AD, Kai Jaquet K, et al. Limited immune modulating activity of porcine mesenchymal stromal cells abolishes their protective efficacy in acute kidney injury. Stem Cells Dev. 2010;19:719-29.
22. Di Mari JF, Davis R, Safirstein RL. MAPK activation determines renal epithelial cell survival during oxidative injury. Am J Physiol. 1999;277:F195-203. (Pubitemid 29415137)
23. Cuttle L, Zhang XJ, Endre Z, Winterford C, Gobe GC. Bcl-X(L) translocation in renal tubular epithelial cells in vitro protects distal cells from oxidative stress. Kidney Int. 2001;59:1779-88. (Pubitemid 32336792)
24. Gobe GC, Johnson DW. Distal tubular epithelial cells of the kidney: potential support for proximal tubular cell survival after renal injury. Int J Biochem Cell Biol. 2007;39:1551-61. (Pubitemid 47088318)
25. Hagiwara M, Shen B, Chao L, Chao J. Kallikrein-modified mesenchymal stem cell implantation provides enhanced protection against acute ischemic kidney injury by inhibiting apoptosis and infl ammation. Hum Gene Ther. 2008;19: 807-19.
26. Beyer Nardi N, da Silva Meirelles L. Mesenchymal stem cells: isolation, in vitro expansion and characterization. Handb Exp Pharmacol. 2006;174:249-82.
27. Montzka K, F ü hrmann T, M ü ller-Ehmsen J, W ö ltje M, Brook GA. Growth factor and cytokine expression of human mesenchymal stromal cells is not altered in an in vitro model of tissue damage. Cytotherapy. 2010;12:870-80.
28. Gobe G, Zhang XJ, Willgoss DA, Schoch E, Hogg NA, Endre ZH. Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat. J Am Soc Nephrol. 2000;11:454-67. (Pubitemid 30115075)
29. Vesey DA, Cheung C, Pat B, Endre Z, Gobe GC, Johnson DW. Erythropoietin protects against ischaemic acute renal injury. Nephrol Dial Transplant. 2004;19:348-55. (Pubitemid 38195983)
30. Johnson DW, Pat B, Vesey DA, Guan Z, Endre Z, Gobe GC. Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure. Kidney Int. 2006;69:1806-13. (Pubitemid 43739209)
31. Hughes J, Gobe GC. Identification and quantification of apoptosis in the kidney using morphology, biochemical and molecular markers. Nephrology (Carlton). 2007;12:452-8. (Pubitemid 47366651)
32. Gobe GC. Identification of apoptosis in kidney tissue sections. Methods Mol Biol. 2009;466:175-92.
33. Iatropoulos MJ, Williams GM. Proliferation markers. Exp Toxicol Pathol. 1996;48:175-81. (Pubitemid 26078643)
34. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002;99:3838-43. (Pubitemid 34534559)
35. Nath KA, Haggard JJ, Croatt AJ, Grande JP, Poss KD, Alam J. The indispensability of heme-oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol. 2000;156:1527-35. (Pubitemid 30646692)
36. Simon T, Anegon I, Blancou P. Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer. Immunotherapy. 2011;3(suppl 4):15-18.
37. Clark JE, Foresti R, Sarathchandra P, Kaur H, Green CJ, Motterlini R. Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2000;278:H643-51.
38. V í tek L, Jirsa M, Brodanov á M, Kalab M, Marecek Z, Danzig V, et al. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis. 2002;160:449-56. (Pubitemid 34159340)
39. Basile DP, Fredrich K, Alausa M, Vio CP, Liang M, Rieder MR, et al. Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure. Am J Physiol Renal Physiol. 2005;288:F953-63.
40. Miyata T, Takizawa S, van Ypersele de Strihou C. Hypoxia. I. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets. Am J Physiol Cell Physiol. 2011; 300:C226-31.