Towards achieving a flattop crystal size distribution by continuous seeding and controlled growth

Chemical Engineering Science

Volumn 77, Issue , 2012, Pages 2-9

  Jiang, Mo ^a,b   Wong, Min Hao ^a   Zhu, Zhilong ^a,b   Zhang, Jieqian ^a   Zhou, Lifang ^a,b   Wang, Ke ^a   Ford Versypt, Ashlee N ^a   Si, Tong ^a   Hasenberg, Lisa M ^a,b   Li, Yao En ^c   Braatz, Richard D ^a,b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

Concentration feedback control; Crystallization; Crystallizer design; Dual impinging jets; Pharmaceuticals; Process intensification

Indexed keywords

ATR FTIR; AUTOMATED SYSTEMS; CALIBRATION MODEL; CONTROLLED GROWTH; CRYSTAL SIZE DISTRIBUTIONS; FOCUSED BEAM REFLECTANCE MEASUREMENT; IMPINGING JET; L-ASPARAGINE MONOHYDRATE; METASTABLE LIMITS; PROCESS INTENSIFICATION; RATE CONTROLS; SATURATED SOLUTIONS; SEMI-CONTINUOUS; STIRRED TANK;

AMINO ACIDS; AUTOMATION; CRYSTALLIZATION; CRYSTALLIZERS; DRUG PRODUCTS; FEEDBACK CONTROL; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GRAIN SIZE AND SHAPE;

SIZE DISTRIBUTION;

EID: 84862901159     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2011.12.033     Document Type: Article

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