The neural bases of grapheme-color synesthesia are not localized in real color-sensitive areas

Cerebral Cortex

Volumn 22, Issue 7, 2012, Pages 1622-1633

  Hupé, Jean Michel ^a   Bordier, Cécile ^b   Dojat, Michel ^b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

Author keywords

fMRI; human vision; synaesthesia; V4 color center; VBM

Indexed keywords

ADAPTATION; ADULT; ARTICLE; COGNITION; COLOR VISION; CONTROLLED STUDY; EXPERIENCE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAPHEME COLOR SYNESTHESIA; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOPHYSICS; RETROSPLENIAL CORTEX; SENSATION; STIMULUS RESPONSE; VISUAL CORTEX; VOXEL BASED MORPHOMETRY; WHITE MATTER;

ADULT; ASSOCIATION LEARNING; COLOR PERCEPTION; CUES; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE NET; STROOP TEST; VISUAL CORTEX; YOUNG ADULT;

EID: 84862900247     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhr236     Document Type: Article

References (71)

1. Acosta-Cabronero J, Williams GB, Pereira JM, Pengas G, Nestor PJ. 2008. The impact of skull-stripping and radio-frequency bias correction on grey-matter segmentation for voxel-based morphometry. Neuroimage. 39:1654-1665.
2. Ashburner J. 2007. A fast diffeomorphic image registration algorithm. Neuroimage. 38:95-113. Ashburner J, Friston KJ. 2005.
3. Ashburner J, Friston KJ. 2005 Unified segmentation. Neuroimage. 26:839-851.
4. Asher JE, Aitken MR, Farooqi N, Kurmani S, Baron-Cohen S. 2006. Diagnosing and phenotyping visual synaesthesia: a preliminary evaluation of the revised test of genuineness (TOG-R). Cortex. 42:137-146.
5. Asher JE, Lamb JA, Brocklebank D, Cazier JB, Maestrini E, Addis L, Sen M, Baron-Cohen S, Monaco AP. 2009. A whole-genome scan and finemapping linkage study of auditory-visual synesthesia reveals evidence of linkage to chromosomes 2q24, 5q33, 6p12, and 12p12. Am J Hum Genet. 84:279-285.
6. Awad M, Warren JE, Scott SK, Turkheimer FE, Wise RJ. 2007. A common system for the comprehension and production of narrative speech. J. Neurosci. 27:11455-11464.
7. Bar M. 2004. Visual objects in context. Nat Rev Neurosci. 5:617-629.
8. Barnett KJ, Finucane C, Asher JE, Bargary G, Corvin AP, Newell FN, Mitchell KJ. 2008. Familial patterns and the origins of individual differences in synaesthesia. Cognition. 106:871-893.
9. Baron-Cohen S, Harrison J, Goldstein LH, Wyke M. 1993. Coloured speech perception: is synaesthesia what happens when modularity breaks down? Perception. 22:419-426.
10. Beeli G, Esslen M, Jancke L. 2008. Time course of neural activity correlated with colored-hearing synesthesia. Cereb Cortex. 18:379-385.
11. Bennett CM, Baird AA, Miller MB, Wolford GL. 2010. Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction. JSUR. 1:1-15.
12. Bennett CM, Miller MB. 2010. How reliable are the results from functional magnetic resonance imaging? Ann N Y Acad Sci. 1191:133-155.
13. Blake R, Palmeri TJ, Marois R, Kim CH. 2005. On the perceptual reality of synesthetic color. In: Robertson LC, Sagiv N, editors. Synesthesia: perspectives from cognitive neuroscience. Oxford: Oxford University Press. p. 47-73.
14. Brewer AA, Liu J, Wade AR, Wandell BA. 2005. Visual field maps and stimulus selectivity in human ventral occipital cortex. Nat Neurosci. 8:1102-1109.
15. Brouwer GJ, Heeger DJ. 2009. Decoding and reconstructing color from responses in human visual cortex. J. Neurosci. 29:13992-14003.
16. Buckner RL, Andrews-Hanna JR, Schacter DL. 2008. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 1124:1-38.
17. Bullmore E, Sporns O. 2009. Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci. 10:186-198.
18. Dann KT. 1998. Bright colors falsely seen: synaesthesia and the search for transcendental knowledge. New Haven: Yale University Press.
19. Dixon MJ, Smilek D. 2005. The importance of individual differences in grapheme-color synesthesia. Neuron. 45:821-823.
20. Dixon MJ, Smilek D, Cudahy C, Merikle PM. 2000. Five plus two equals yellow. Nature. 406:365.
21. Dixon MJ, Smilek D, Merikle PM. 2004. Not all synaesthetes are created equal: projector versus associator synaesthetes. Cogn Affect Behav Neurosci. 4:335-343.
22. Eagleman DM, Kagan AD, Nelson SS, Sagaram D, Sarma AK. 2007. A standardized test battery for the study of synesthesia. J Neurosci Methods. 159:139-145.
23. Edquist J, Rich AN, Brinkman C, Mattingley JB. 2006. Do synaesthetic colours act as unique features in visual search? Cortex. 42:222-231.
24. Efron B, Tibshirani RJ. 1993. An introduction to the bootstrap. New York: Chapman & Hall.
25. Elias LJ, Saucier DM, Hardie C, Sarty GE. 2003. Dissociating semantic and perceptual components of synaesthesia: behavioural and functional neuroanatomical investigations. Brain Res Cogn Brain Res. 16:232-237.
26. Fair DA, Cohen AL, Dosenbach NU, Church JA, Miezin FM, Barch DM, Raichle ME, Petersen SE, Schlaggar BL. 2008. The maturing architecture of the brain's default network. Proc Natl Acad Sci USA. 105:4028-4032.
27. Flournoy T. 1893. Des phénomè nes de synopsie (audition coloré e) photismes, schèmes visuels, personnifications. Paris: Alcan.
28. Gheri C, Chopping S, Morgan MJ. 2008. Synaesthetic colours do not camouflage form in visual search. Proc Biol Sci. 275:841-846.
29. Goller AI, Otten LJ, Ward J. 2008. Seeing sounds and hearing colors: an event-related potential study of auditory-visual synesthesia. J Cogn Neurosci. 10:869-881.
30. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. 2001. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 14:21-36.
31. Hanggi J, Beeli G, Oechslin MS, Jancke L. 2008. The multiple synaesthete E.S.: neuroanatomical basis of interval-taste and tonecolour synaesthesia. Neuroimage. 43:192-203.
32. Hanggi J, Wotruba D, Jancke L. 2011. Globally altered structural brain network topology in grapheme-color synesthesia. J. Neurosci. 31:5816-5828.
33. Hong SW, Blake R. 2008. Early visual mechanisms do not contribute to synesthetic color experience. Vision Res. 48:1018-1026.
34. Hubbard EM, Arman AC, Ramachandran VS, Boynton GM. 2005. Individual differences among grapheme-color synesthetes: brainbehavior correlations. Neuron. 45:975-985.
35. Hubbard EM, Ramachandran VS. 2005. Neurocognitive mechanisms of synesthesia. Neuron. 48:509-520.
36. Jancke L, Beeli G, Eulig C, Hanggi J. 2009. The neuroanatomy of grapheme-color synesthesia. Eur J Neurosci. 29:1287-1293.
37. Kobayashi Y, Amaral DG. 2007. Macaque monkey retrosplenial cortex: III. Cortical efferents. J Comp Neurol. 502:810-833.
38. Laeng B, Svartdal F,Oelmann H. 2004. Does color synesthesia pose a paradox for early-selection theories of attention? Psychol Sci. 15:277-281.
39. Larsson J, Heeger DJ. 2006. Two retinotopic visual areas in human lateral occipital cortex. J. Neurosci. 26:13128-13142.
40. Maddock RJ. 1999. The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends Neurosci. 22:310-316.
41. Mattingley JB, Rich AN, Yelland G, Bradshaw JL. 2001. Unconscious priming eliminates automatic binding of colour and alphanumeric form in synaesthesia. Nature. 410:580-582.
42. Nijboer TC, Van der Stigchel S. 2009. Is attention essential for inducing synesthetic colors? Evidence from oculomotor distractors. J. Vis. 9(6):21:1-9. doi:10.1167/9.6.21.
43. Nunn JA, Gregory LJ, Brammer M, Williams SC, Parslow DM, Morgan MJ, Morris RG, Bullmore ET, Baron-Cohen S, Gray JA. 2002. Functional magnetic resonance imaging of synesthesia: activation of V4/V8 by spoken words. Nat Neurosci. 5:371-375.
44. O'Toole AJ, Jiang F, Abdi H, Penard N, Dunlop JP, Parent MA. 2007. Theoretical, statistical, and practical perspectives on pattern-based classification approaches to the analysis of functional neuroimaging data. J Cogn Neurosci. 19:1735-1752.
45. Palmeri TJ, Blake R, Marois R, Flanery MA, Whetsell W, Jr. 2002. The perceptual reality of synesthetic colors. Proc Natl Acad Sci USA. 99:4127-4131.
46. Paulesu E, Harrison J, Baron-Cohen S, Watson JD, Goldstein L, Heather J, Frackowiak RS, Frith CD. 1995. The physiology of coloured hearing. A PET activation study of colour-word synaesthesia. Brain. 118(Pt 3):661-676.
47. Ramachandran VS, Hubbard EM. 2001a. Psychophysical investigations into the neural basis of synaesthesia. Proc R Soc Lond B Biol Sci. 268:979-983.
48. Ramachandran VS, Hubbard EM. 2001b. Synaesthesia-a window into perception, language and thought. J Conscious Stud. 8:3-34.
49. Rich AN, Mattingley JB. 2002. Anomalous perception in synaesthesia: a cognitive neuroscience perspective. Nat Rev Neurosci. 3:43-52.
50. Rich AN, Williams MA, Puce A, Syngeniotis A, Howard MA, McGlone F, Mattingley JB. 2006. Neural correlates of imagined and synaesthetic colours. Neuropsychologia. 44:2918-2925.
51. Robertson LC, Sagiv N. 2005. Synesthesia: perspectives from cognitive neuroscience. New York: Oxford University Press.
52. Rothen N, Meier B. 2009. Do synesthetes have a general advantage in visual search and episodic memory? A case for group studies. PLoS One. 4:e5037.
53. Rouw R, Scholte HS. 2007. Increased structural connectivity in grapheme-color synesthesia. Nat Neurosci. 10:792-797.
54. Rouw R, Scholte HS. 2010. Neural basis of individual differences in synesthetic experiences. J. Neurosci. 30:6205-6213.
55. Sagiv N, Heer J, Robertson L. 2006. Does binding of synesthetic color to the evoking grapheme require attention? Cortex. 42:232-242.
56. Simner J, Harrold J, Creed H, Monro L, Foulkes L. 2009. Early detection of markers for synaesthesia in childhood populations. Brain. 132:57-64.
57. Simner J, Mulvenna C, Sagiv N, Tsakanikos E, Witherby SA, Fraser C, Scott K, Ward J. 2006. Synaesthesia: the prevalence of atypical crossmodal experiences. Perception. 35:1024-1033.
58. Specht K, Willmes K, Shah NJ, Jancke L. 2003. Assessment of reliability in functional imaging studies. J Magn Reson Imaging. 17:463-471.
59. Sperling JM, Prvulovic D, Linden DE, Singer W, Stirn A. 2006. Neuronal correlates of colour-graphemic synaesthesia: a fMRI study. Cortex. 42:295-303.
60. Suarez de Mendoza F. 1890. L'audition coloré e: é tude sur les fausses sensations secondaires physiologiques et particulièrement sur les pseudo-sensations de couleurs associé es aux perceptions objectives des sons. Paris: Doin.
61. Supekar K, Musen M, Menon V. 2009. Development of large-scale functional brain networks in children. PLoS Biol. 7:e1000157.
62. Vann SD, Aggleton JP, Maguire EA. 2009. What does the retrosplenial cortex do? Nat Rev Neurosci. 10:792-802.
63. Wandell BA, Dumoulin SO, Brewer AA. 2007. Visual field maps in human cortex. Neuron. 56:366-383.
64. Ward J. 2004. Emotionally mediated synaesthesia. Cogn Neuropsychol. 21:761-772.
65. Ward J, Jonas C, Dienes Z, Seth A. 2010. Grapheme-colour synaesthesia improves detection of embedded shapes, but without pre-attentive 'pop-out' of synaesthetic colour. Proc Biol Sci. 277:1021-1026.
66. Ward J, Li R, Salih S, Sagiv N. 2007. Varieties of grapheme-colour synaesthesia: a new theory of phenomenological and behavioural differences. Conscious Cogn. 16:913-931.
67. Ward J, Thompson-Lake D, Ely R, Kaminski F. 2008. Synaesthesia, creativity and art: what is the link? Br J Psychol. 99:127-141.
68. Weiss PH, Fink GR. 2009. Grapheme-colour synaesthetes show increased grey matter volumes of parietal and fusiform cortex. Brain. 132:65-70.
69. Weiss PH, Shah NJ, Toni I, Zilles K, Fink GR. 2001. Associating colours with people: a case of chromatic-lexical synaesthesia. Cortex. 37:750-753.
70. Weiss PH, Zilles K, Fink GR. 2005. When visual perception causes feeling: enhanced cross-modal processing in grapheme-color synesthesia. Neuroimage. 28:859-868.
71. Wirth M, Jann K, Dierks T, Federspiel A, Wiest R, Horn H. 2011. Semantic memory involvement in the default mode network: a functional neuroimaging study using independent component analysis. Neuroimage. 54:3057-3066.