Compromised white matter microstructural integrity after mountain climbing: Evidence from diffusion tensor imaging

High Altitude Medicine and Biology

Volumn 13, Issue 2, 2012, Pages 118-125

  Zhang, Haiyan ^a   Lin, Jianzhong ^a   Sun, Yingchun ^a   Huang, Yongxia ^a   Ye, Huiming ^a   Wang, Xiaochuan ^b   Yang, Tianhe ^a   Jiang, Xingtang ^a   Zhang, Jiaxing ^a  

^a XIAMEN UNIVERSITY   (China)

^b Second Hospital of Hangzhou   (China)

Author keywords

gray matter; high altitude; mountain climbing; MRI; white matter

Indexed keywords

ADULT; ANISOTROPY; ARTICLE; BRAIN SIZE; CEREBROSPINAL FLUID; COGNITION; CORPUS CALLOSUM; DIFFUSION TENSOR IMAGING; FEMALE; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; MALE; MESENCEPHALON; MOLECULAR MECHANICS; MOUNTAINEERING; NEUROANATOMY; NORMAL HUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; QUANTITATIVE ANALYSIS; VOXEL BASED MORPHOMETRY; WHITE MATTER;

ADULT; ANISOTROPY; BRAIN; COGNITION; CORPUS CALLOSUM; DIFFUSION TENSOR IMAGING; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MALE; MOUNTAINEERING; PYRAMIDAL TRACTS; TEGMENTUM MESENCEPHALI; YOUNG ADULT;

EID: 84862896752     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2011.1073     Document Type: Article

References (53)

1. Anooshiravani M, Dumont L, Mardirosoff C, Soto-Debeuf G, and Delavelle J. (1999). Brain magnetic resonance imaging (MRI) and neurological changes after a single high altitude climb. Med Sci Sports Exerc 31:969-972. (Pubitemid 29316192)
2. Ashburner J. (2007). A fast diffeomorphic image registration algorithm. NeuroImage 38:95-113. (Pubitemid 47440133)
3. Bailey DM, Bartsch P, Knauth M, and Baumgartner RW. (2009). Emerging concepts in acute mountain sickness and highaltitude cerebral edema: From the molecular to the morphological. Cell Mol Life Sci 66:3583-3594.
4. Beaulieu C. (2002). The basis of anisotropic water diffusion in the nervous system-a technical review. NMR. Biomed. 15:435-455. (Pubitemid 36054508)
5. Bechtel N, Kobel M, Penner IK, Klarhöfer M, Scheffler K, Opwis K, and Weber P. (2009). Decreased fractional anisotropy in the middle cerebellar peduncle in children with epilepsy and/or attention deficit/hyperactivity disorder: A preliminary study. Epilepsy Behav 15:294-298.
6. Bolmont B, Thullier F, and Abraini JH. (2000). Relationships between mood states and performances in reaction time, psychomotor ability, and mental efficiency during a 31-day gradual decompression in a hypobaric chamber from sea level to 8848m equivalent altitude. Physiol Behav 71:469-476. (Pubitemid 32184770)
7. Chen Z, Li L, Sun J, and Ma L. (2011). Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL. Eur J Radiol [Epub ahead of print]
8. Clark CF, Heaton RK, and Wiens AN. (1983). Neuropsychological functioning after prolonged high altitude exposure in mountaineering. Aviat Space Environ Med 54:202-207. (Pubitemid 13091111)
9. Delsing BJP, Catsman-Berrevoets CE, and Appel IM. (2001). Early prognostic indicators of outcome in ischemic childhood stroke. Pediatr Neurol 24:283-289. (Pubitemid 32463862)
10. Di Paola M, Bozzali M, Fadda L, Musicco M, Sabatini U, and Caltagirone C. (2008). Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areas. Eur J Neurol 15:1050-1057.
11. Drobyshevsky A, Derrick M, Wyrwicz AM, Ji X, Englof I, Ullman LM, Zelaya ME, Northington FJ, and Tan S. (2007). White matter injury correlates with hypertonia in an animal model of cerebral palsy. J Cereb Blood Flow Metab 27:270281.
12. Ewing-Cobbs L, Hasan KM, Prasad MR, Kramer L, and Bachevalier J. (2006). Corpus callosum diffusion anisotropy correlates with neuropsychological outcomes in twins disconcordant for traumatic brain injury. AJNR Am J Neuroradiol 27:879-881. (Pubitemid 44897740)
13. Fayed N, Modrego PJ, and Morales H. (2006). Evidence of brain damage after high-altitude climbing by means of magnetic resonance imaging. Am J Med 119:1-6.
14. Fischer R, Vollmar C, Thiere M, Born C, Leitl M, Pfluger T, and Huber RM. (2004). No evidence of cerebral oedema in severe acute mountain sickness. Cephalalgia 24:66-71. (Pubitemid 38085197)
15. Garrido E, Castello A, Ventura JL, Capdevila A, and Rodríguez FA. (1993). Cortical atrophy and other brain MRI changes after extremely high-altitude climbs without oxygen. Int J Sports Med 14:232-234. (Pubitemid 23151626)
16. Gulani V and Sundgren PC. (2006). Diffusion tensor magnetic resonance imaging. J Neuroophthalmol 26:51-60. (Pubitemid 44502763)
17. Hackett PH and Roach RC. (2001). High-altitude illness. N Engl J Med 345:107-114. (Pubitemid 32634570)
18. Hackett PH and Roach RC. (2004). High altitude cerebral edema. High Alt Med Biol 5:136-146. (Pubitemid 39069615)
19. Hackett PH, Yarnell PR, Hill R, Reynard K, Heit J, and McCormick J. (1998). High-altitude cerebral edema evaluated with magnetic resonance imaging: Clinical correlation and pathophysiology. J Am Med Assoc 280:1920-1925. (Pubitemid 28559809)
20. Hanyu H, Imon Y, Sakurai H, Iwamoto T, Takasaki M, Shindo H, Kakizaki D, and Abe K. (1999). Regional differences in diffusion abnormality in cerebral white matter lesions in patients with vascular dementia of the Binswanger type and Alzheimer's disease. Eur J Neurol 6:195-203. (Pubitemid 29141901)
21. Harris GA, Cleland J, Collie A, and McCrory P. (2009). Cognitive assessment of a trekking expedition to 5100 m: A comparison of computerized and written testing methods. Wilderness Environ Med 20:261-268.
22. Hochachka PW, Clark CM, Matheson GO, Brown WD, Stone CK, Nickles RJ, and Holden JE. (1999). Effects on regional brain metabolism of high-altitude hypoxia: A study of six US marines. Am J Physiol 277:R314-319. (Pubitemid 29356808)
23. Hornbein TF, Townes BD, Schoene RB, Sutton JR, and Houston CS. (1989). The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med 321:1714-1719. (Pubitemid 20020547)
24. Jang SH. (2009). A review of corticospinal tract location at corona radiata and posterior limb of the internal capsule in human brain. Neuro Rehab 24:279-283.
25. Jason GW, Pajurkova EM, and Lee RG. (1989). High altitude mountaineering and brain function: Neuropsychological testing of members of a Mount Everest expedition. Aviat Space Environ Med 60:170-173. (Pubitemid 19053903)
26. Jenkinson M and Smith S. (2001). A global optimisation method for robust affine registration of brain images. Med Image Anal 5:143-156. (Pubitemid 35282800)
27. Kallenberg K, Bailey DM, Christ S, Mohr A, Roukens R, Menold E, Steiner T, Bartsch P, and Knauth M. (2007). Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness. J Cereb Blood Flow Metab 27:1064-1071. (Pubitemid 46659029)
28. Konczak J and Timmann D. (2007). The effect of damage to the cerebellum on sensorimotor and cognitive function in children and adolescents. Neurosci Biobehav R 31:1101-1113. (Pubitemid 350160946)
29. Kusano Y, Seguchi T, Horiuchi T, Kakizawa Y, Kobayashi T, Tanaka Y, Seguchi K, and Hongo K. (2009). Prediction of functional outcome in acute cerebral hemorrhage using diffusion tensor imaging at 3T: A prospective study. AJNR Am J Neuroradiol 30:1561-1565.
30. Lieberman P, Protopapas A, Reed E, Youngs JW, and Kanki BG. (1994). Cognitive defects at altitude. Nature 372:325.
31. Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, and Harper RM. (2008). Brain structural changes in obstructive sleep apnea. Sleep 31:967-977. (Pubitemid 351956936)
32. McNally MA, Crocetti D, Mahone EM, Denckla MB, Suskauer SJ, and Mostofsky SH. (2010). Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD). J Child Neurol 25:453-462.
33. Merz TM, Treyer V, Hefti U, Spengler CM, Schwarz U, Buck A, and Maggiorini M. (2006). Changes in cerebral glucose metabolism after an expedition to high altitudes. High Alt Med Biol 7:28-38.
34. Morocz IA, Zientara GP, Gudbjartsson H, Muza S, Lyons T, Rock PB, Kikinis R, and Jolesz FA. (2001). Volumetric quantification of brain swelling after hypobaric hypoxia exposure. Exp Neurol 168:96-104. (Pubitemid 32195261)
35. Oliveri M, Torriero S, Koch G, Salerno S, Petrosini L, and Caltagirone C. (2007). The role of transcranial magnetic stimulation in the study of cerebellar cognitive function. Cerebellum 6:95-101. (Pubitemid 46410665)
36. Pagani M, Ravagnan G, and Salmaso D. (1998). Effect of acclimatisation to altitude on learning. Cortex 34:243-251. (Pubitemid 28230966)
37. Patwari PP, Carroll MS, Rand CM, Kumar R, Harper R, and Weese-Mayer DE. (2010). Congenital central hypoventilation syndrome and the PHOX2B gene: A model of respiratory and autonomic dysregulation. Respir Physiol Neurobiol 173:322-335.
38. Regard M, Oelz O, Brugger P, and Landis T. (1989). Persistent cognitive impairment in climbers after repeated exposure to extreme altitude. Neurology 39:210-213. (Pubitemid 19059306)
39. Roach RC, Bartsch P, Oelz O, and Hackett PH. (1993). Lake Louise AMS, Scoring Consensus Committee. The Lake Louise acute mountain sickness scoring system, Hypoxia and molecular medicine. Queen City Printers, Burlington, pp. 272-274.
40. Rostrup E, Larsson HB, Born AP, Knudsen GM, and Paulson OB. (2005). Changes in BOLD and ADC weighted imaging in acute hypoxia during sea-level and altitude adapted states. Neuroimage 28:947-955. (Pubitemid 41713629)
41. Ryberg C, Rostrup E, Paulson OB, Barkhof F, Scheltens P, van Straaten EC, van der Flier WM, Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H, Wahlund LO, Poggesi A, Pantoni L, Inzitari D, Waldemar G, and on behalf of the LADIS study group. (2011). Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort. J Neurol Sci 307:100-105.
42. Smith SM, Johansen-Berg H, Jenkinson M, Rueckert D, Nichols TE, Miller KL, Robson MD, Jones DK, Klein JC, Bartsch AJ, and Behrens TE. (2007). Acquisition and voxelwise analysis of multi-subject diffusion data with tract-based spatial statistics. Nat Protocols 2:499-503.
43. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, and Cross AH. (2002). Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 17:1429-1436. (Pubitemid 35333862)
44. Stoodley CJ. (2011). The cerebellum and cognition: Evidence from functional imaging studies. Cerebellum 2012;11:352-365.
45. Thomalla G, Glauche V, Koch MA, Beaulieu C, Weiller C, and Rother J. (2004). Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke. Neuroimage 22:1767-1774. (Pubitemid 38962664)
46. Torriero S, Oliveri M, Koch G, Lo Gerfo E, Salerno S, Petrosini L, and Caltagirone C. (2007). Cortical networks of procedural learning: Evidence from cerebellar damage. Neuropsychologia 45:1208-1214. (Pubitemid 46072912)
47. Tripathi KK, Apte CV, and Mukundan CR. (2005). Temporal adjustments in working memory and vigilance function during 6 days of acclimatization at 10,500 feet altitude. Ind J Aerospace Med 49:20-28.
48. Usui C, Inoue Y, Kimura M, Kirino E, Nagaoka S, Abe M, Nagata T, and Arai H. (2004). Irreversible subcortical dementia following high altitude illness. High Alt Med Biol 5:77-81. (Pubitemid 38455807)
49. Versace A, Almeida JR, Hassel S, Walsh ND, Novelli M, Klein CR, Kupfer DJ, and Phillips ML. (2008). Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch Gen Psychiatry 65:1041-1052.
50. West JB. (1984). Human physiology at extreme altitudes on Mount Everest. Science 223:784-788.
51. West JB. (2004). The physiologic basis of high-altitude diseases. Ann Intern Med 141:789-800. (Pubitemid 39524917)
52. Zhang J, Liu H, Yan X, and Weng X. (2011). Minimal effects on human memory following long-term living at moderate altitude. High Alt Med Biol. 12:37-43.
53. Zhang J, Yan X, Shi J, Gong Q, Weng X, and Liu Y. (2010). Structural modifications of the brain in acclimatization to high-altitude. PLoS ONE. 5:e11449.