Role of progranulin gene expression as a molecular biomarker for bladder cancer

American Journal of Biochemistry and Biotechnology

Volumn 8, Issue 2, 2012, Pages 71-80

  Abo El khair, Salwa M ^a   Mohamed, Mie A ^a   Alkhiary, Tamer E ^b  

^a MANSOURA UNIVERSITY   (Egypt)

^b Surgical Oncology Unit   (Egypt)

Author keywords

Acceptable sensitivity; Potential biomarkers; Progranulin; RT PCR; Urothelial Cell Carcinoma (UCC)

Indexed keywords

ACCEPTABLE SENSITIVITY; BLADDER CANCERS; CELLULAR PROLIFERATIONS; CONTROL SUBJECT; CUT-OFF VALUE; EARLY DIAGNOSIS; ENZYME IMMUNOASSAY; GROWTH FACTOR; MOLECULAR BIOMARKER; MOLECULAR MARKER; OVER-EXPRESSION; PROGRANULIN; RT-PCR; SENSITIVITY AND SPECIFICITY; SIGNIFICANT IMPACTS; URINARY BIOMARKERS; URINARY SYSTEM; URINE SAMPLE; UROTHELIAL CELLS;

BIOMARKERS; CELL PROLIFERATION; CYTOLOGY; DIAGNOSIS; GENES; RISK PERCEPTION; TRANSCRIPTION; TUMORS;

DISEASES;

BIOLOGICAL MARKER; PROGRANULIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER DIAGNOSIS; CANCER GRADING; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME IMMUNOASSAY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; URINALYSIS; URINE SEDIMENT;

EID: 84862874986     PISSN: 15533468     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajbbsp.2012.71.80     Document Type: Article

References (46)

1. Baba, T., H.B. Hoff, H. Nemoto, H. Lee and J. Orth et al., 1993. Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growthmodulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells. Mol. Reprod. Dev., 34: 233-243. DOI: 10.1002/mrd.1080340302
2. Bateman, A., D. Belcourt, H. Bennett, C. Lazure and S. Solomon, 1990. Granulins, a novel class of peptide from leukocytes. Biochem. Biophys. Res. Commun., 173: 1161-1168. DOI: 10.1016/S0006-291X(05)80908-8
3. Berchtold, M.W., 1989. A simple method for direct cloning and sequencing cDNA by the use of a single specific oligonucleotide and oligo(dT) in a Polymerase Chain Reaction (PCR). Nucl. Acids Res., 17: 453-453. DOI: 10.1093/nar/17.1.453
4. Blaveri, E., J.P. Simko, J.E. Korkola, J.L. Brewer and F. Baehner, 2005. Bladder cancer outcome and subtype classification by gene expression. Clin. Cancer Res., 11: 4044-4044. DOI: 10.1158/1078-0432.CCR-04-2409
5. Chen, H.Y., C.H. Shen, Y.T. Tsai, F.C. Lin and Y.P. Huang et al., 2004. Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol. Cell Biol., 24: 10558-10572. DOI: 10.1128/MCB.24.24.10558-10572.2004
6. Cuevas-Antonio, R., C. Cancino, F. Arechavaleta-Velasco, A. Andrade and L. Barron et al., 2010. Expression of progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line. Cancer Invest., 28: 452-458. DOI: 10.3109/07357900903346455
7. Devoogdt, N., N. Rasool, E. Hoskins, F. Simpkins and N. Tchabo et al., 2009. Overexpression of protease inhibitor-dead secretory leukocyte protease inhibitor causes more aggressive ovarian cancer in vitro and in vivo. Cancer Sci., 100: 434-440. DOI: 10.1111/j.1349-7006.2009.01076.x
8. Dey, P., 2004. Urinary markers of bladder carcinoma. Clin. Chim. Acta 340: 57-65. DOI: 10.1016/j.cccn.2003.11.008
9. Donald, C.D., A. Laddu, P. Chandham, S.D. Lim and C. Cohen et al., 2001. Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium. Anticancer Res., 21: 3739-3742. PMID: 11911241
10. Eble, J.N., 2004. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. 1st Edn., IARC Press Lyon, Lyon, ISBN-10: 9283224159, pp: 359.
11. Glas, A.S., D. Roos, M. Deutekom, A.H. Zwinderman and P.M. Bossuyt et al., 2003. Tumor markers in the diagnosis of primary bladder cancer. A systematic review. J. Urol., 169: 1975-1982. DOI: 10.1097/01.ju.0000067461.30468.6d
12. Grossman, H.B., M. Soloway and E. Messing, 2006. Surveillance for recurrent bladder cancer using a point-of-care proteomic assay. JAMA, 295: 299-305. DOI: 10.1001/jama.295.3.299
13. Guo, W. and F.G. Giancotti, 2004. Integrin signalling during tumour progression. Nat. Rev. Mol. Cell Biol., 5: 816-826. DOI: 10.1038/nrm1490
14. Hautmann, S., M. Toma and M.F.L. Gomez, 2004. Immunocyt and the HA-HAase urine tests for the detection of bladder cancer: A side-by-side comparison. Eur. Urol., 46: 466-471. DOI: 10.1016/j.eururo.2004.06.006
15. He, Z. and A. Bateman, 2003. Progranulin (granulinepithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J. Mol. Med., 81: 600-612. DOI: 10.1007/s00109-003-0474-3
16. He, Z., A. Ismail, L. Kriazhev, G. Sadvakassova and A. Bateman, 2002. Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival. Cancer Res., 62: 5590-5596.
17. Ho, J.C., Y.C. Ip, S.T. Cheung, Y.T. Lee and K.F. Chan et al., 2008. Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. Hepatology, 47: 1524-1532. DOI: 10.1002/hep.22191
18. Holyoake, A., P. O'Sullivan, R. Pollock, T. Best and J. Watanabe et al., 2008. Development of a multiplex rna urine test for the detection and stratification of transitional cell carcinoma of the bladder. Clin. Cancer Res., 14: 742-742. DOI: 10.1158/1078-0432.CCR-07-1672
19. Hu, Y., D.M. Lin, S.J. Cheng, Y.N. Liu and F.Y. Feng, 2006. Influences of PC cell-derived growth factor and breast cancer resistance protein on the curative effects of platinum-based chemotherapeutic regimens for advanced non-small cell lung cancer. Natl. Med. J. China (Chin), 86: 2611-2614. PMID: 17198586
20. Jones, M.B., A.P. Houwink, B.K. Freeman, T.M. Greenwood and J.M. Lafky et al., 2006. The granulin-epithelin precursor is a steroid-regulated growth factor in endometrical cancer. J. Soc. Gynecol. Investig., 13: 304-311. DOI: 10.1016/j.jsgi.2006.03.003
21. Khalbuss, W. and S. Goodison, 2006. Immunohistochemical detection of hTERT in urothelial lesions: A potential adjunct to urine cytology. Cytojournal, 3: 18-18. DOI: 10.1186/1742-6413-3-18
22. Li-qin, L., H. Hui-lian, P. Jin-liang, W. Xiao-hong and Z. Jing et al., 2011. Clinicopathologic and prognostic implications of progranulin in breast carcinoma. Chin. Med. J., 124: 2045-2050. PMID: 22088468
23. Liu, Y., L. Xi, G. Liao, W. Wang and X. Tian et al., 2007. Inhibition of PC cell-derived growth factor (PCDGF)/Granulin-Epithelin Precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2. BMC Cancer, 7: 22-22. DOI: 10.1186/1471-2407-7-22
24. Lokeshwar, V.B., T. Habuchi and H.B. Grossman, 2005. Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers. Urology, 66: 35-63. DOI: 10.1016/j.urology.2005.08.064
25. Lotan, Y., K. Bensalah, T. Ruddell, S.F. Shariat and A.I. Sagalowsky et al., 2008. Prospective evaluation of the clinical usefulness of reflex fluorescence in situ hybridization assay in patients with atypical cytology for the detection of urothelial carcinoma of the bladder. J. Urol., 179: 2164-2169. DOI: 10.1016/j.juro.2008.01.105
26. Lovat, F., A. Bitto, S.Q. Xu, M. Fassan and S. Goldoni et al., 2009. Proepithelin is an autocrine growth factor for bladder cancer. Carcinogenesis, 30: 861-868. DOI: 10.1093/ carcin /bgp050
27. Lu, R. and G. Serrero, 1999. Stimulation of PC Cellderived growth factor (Epithelin/Granulin Precursor) expression by estradiol in human breast cancer cells. Biochem. Biophys. Res. Commun., 256: 204-207. DOI: 10.1006/bbrc.1999.0253
28. Lu, R. and G. Serrero, 2000. Inhibition of PC cellderived growth factor (PCDGF, epithelin /granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. Proc. Natl Acad. Sci. USA., 97: 3993-3998. DOI: 10.1073/pnas.97.8.3993
29. Lu, R. and G. Serrero, 2001. Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). Proc. Natl Acad. Sci. USA., 98: 142-147. DOI: 10.1073/pnas.011525198
30. Mengual, L., M. Burset, M.J. Ribal, E. Ars and M. Marín-Aguilera et al., 2010. Gene expression signature in urine for diagnosing and assessing aggressiveness of bladder urothelial carcinoma. Clin. Cancer Res., 16: 2624-2633. DOI: 10.1158/1078-0432.CCR-09-3373
31. Monami, G., E.M. Gonzalez, M. Hellman, L.G. Gomella and R. Baffa et al., 2006. Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex. Cancer Res., 66: 7103-7103. DOI: 10.1158/0008-5472.CAN-06-0633
32. Monami, G., V. Emiliozzi, A. Bitto, F. Lovat and S.Q. Xu et al., 2009. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth. Am. J. Pathol., 174: 1037-1047. DOI: 10.2353/ajpath.2009.080735
33. Nielsen, M.E., E.M. Schaeffer, R.W. Veltri, M.P. Schoenberg and R.H. Getzenberg, 2006. Urinary markers in the detection of bladder cancer: What's new. Curr. Opin. Urol., 16: 350-355. DOI: 10.1097/01.mou.0000240308.62958.50
34. Plowman, G.D., J.M. Green, M.G. Neubauer, S.D. Buckley and V.L. McDonald et al., 1992. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. J. Biol. Chem., 267: 13073-13078. PMID: 1618805
35. Rhijn, B.W., H.G. van der Poel and T.H. van der Kwast, 2005. Urine markers for bladder cancer surveillance: A systematic review. Eur. Urol., 47: 736-748. DOI: 10.1016/j.eururo.2005.03.014
36. Rosser, C.J., L. Liu, Y. Sun, P. Villicana and M. McCullers et al., 2009. Bladder cancer-associated gene expression signatures identified by profiling of exfoliated urothelia. Cancer Epidemiol. Biomarkers Prev., 18: 444-444. DOI: 10.1158/1055-9965.EPI-08-1002
37. Selmy, M.A., G.H. Ibrahim, T.I. El Serafi and A.A. Ghobeish, 2010. Evaluation of urinary proepithelin as a potential biomarker for bladder cancer detection and prognosis in Egyptian patients. Cancer Biomark. 7: 163-170. DOI: 10.3233/CBM-2010-0186
38. Stewart, D.J., 2010. Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. Crit. Rev. Oncol. Hematol., 75: 173-234. DOI: 10.1016/j.critrevonc.2009.11.006
39. Swellam, M. and A.A.A. El-Aal, 2005. Correlation between tissue and released VEGF levels in urine of bladder cancer patients. Am. J. Biochem. Biotechnol., 1: 37-42. DOI: 10.3844/ajbbsp.2005.37.42
40. Tangkeangsirisin, W. and G. Serrero, 2004. PC cellderived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells. Carcinogenesis, 25: 1587-92. DOI: 10.1093/carcin/bgh171
41. Walker, J.M. and R. Rapley, 2008. Molecular Biomethods Handbook. 2nd Edn., Springer, ISBN-10: 1603273700, pp: 1124.
42. Wang, W., J. Hayashi and G. Serrero, 2006. PC cellderived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Clin. Cancer Res., 12: 49-56. DOI: 10.1158/1078-0432.CCR-05-0929
43. Xu, S.Q., D. Tang, S. Chamberlain, G. Pronk and F.R. Masiarz et al., 1998. The granulin/epithelin precursor abrogates the requirement for the insulinlike growth factor 1 receptor for growth in vitro. J. Biol. Chem., 273: 20078-20083. DOI: 10.1074/jbc.273.32.20078
44. Yoshida, K., T. Sugino, H. Tahara, A. Woodman and J. Bolodeoku et al., 1997. Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine. Cancer, 79: 362-369.
45. Zhang, Y. and A. Bateman, 2011. The Glycoprotein growth factor progranulin promotes carcinogenesis and has potential value in anti-cancer therapy. J. Carcinogene Mutagene, S2: 001.
46. Zhu, J., C. Nathan, W. Jin, D. Sim and G.S. Ashcroft et al., 2002. Conversion of proepithelin to epithelins: Roles of SLPI and elastase in host defense and wound repair. Cell., 111: 867-878. PMID: 12526812