Synthesis and evaluation of peptidyl α,β-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors

Archives of Pharmacal Research

Volumn 35, Issue 3, 2012, Pages 469-479

  Mallik, Shyam Kumar ^a   Li, Da Yu ^a   Cui, Minghua ^a   Song, Hyun Ok ^a   Park, Hyun ^a   Kim, Hak Sung ^a  

^a Wonkwang University   (South Korea)

Author keywords

unsaturated carbonyl derivatives; Calpain inhibitor; Dipeptidyl ; Malarial calpain; Michael addition

Indexed keywords

ANTIMALARIAL AGENT; BENZYL 1 (DIMETHYLAMINO) 6 METHYL 1 OXOHEPT 2 EN 4YLCARBAMATE; BENZYL 1 [5 (DIMETHYLAMINO) 5 OXO 1 PHENYLPENT 3 EN 2 YLAMINO] 4 METHYL 1 OXOPENTAN 2 YLCARBAMATE; BENZYL 4 METHYL 1 5(MORPHOLINO 5 OXO 1 PHENYLPENT 3 EN 2 YLAMINO) 1 OXOPENTAN 2 YLCARBAMATE; BENZYL 4 METHYL 1 OXO 1 [5 OXO 1 PHENYL 5 (PIPERIDIN 1 YL)PENT 3 EN 2 YLAMINO]PENTAN 2 YLCARBAMATE; BENZYL 4 METHYL 1 OXO 1 [5 OXO 1 PHENYL 5 (PYRROLIDIN 1 YL)PENT 3 EN 2 YLAMINO]PENTAN 2 YLCARBAMATE; BENZYL 6 METHYL 1 (METHYLAMINO) 1 OXOHEPT 2EN 4 YLCARBAMATE; BENZYL 6 METHYL 1 MORPHOLINO 1 OXOHEPT 2 EN 4 YLCARBAMATE; BENZYL 6 METHYL 1 OXO 1 (PIPERIDIN 1 YL)HEPT 2 EN4 YLCARBAMATE; BENZYL 6 METHYL 1 OXO 1 (PYRROLIDIN 1 YL)HEPT 2 EN4 YLCARBAMATE; CALPASTATIN; CARBONYL DERIVATIVE; ETHYL 4 [2 (BENZYLOXYCARBONYLAMINO) 4 METHYLPENTANAMIDO] 5 PHENYLPENT 2 ENOATE; ETHYL 4 [2 (TERT BUTOXYCARBONYLAMINO) 3 PHENYLPROPANAMIDO] 5 PHENYLPENT 2 ENOATE; ETHYL 4 [2 (TERT BUTOXYCARBONYLAMINO) 4 METHYLPENTANAMIDO] 5 PHENYLPENT 2 ENOATE; PEPTIDYL ALPHA,BETA UNSATURATED CARBONYL DERIVATIVE; TERT BUTYL 1 [5 (DIMETHYLAMINO) 5 OXO 1 PHENYLPENT 3 EN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YLCARBAMATE; TERT BUTYL 1 [5 (DIMETHYLAMINO) 5 OXO 1 PHENYLPENT 3 EN 2YLAMINO] 4 METHYL 1 OXOPENTAN 2 YL CARBAMATE; TERT BUTYL 1 [5 (METHYLAMINO) 5 OXO 1 PHENYLPENT 3 EN 2 YLAMINO] 1 OXO 3 PHENYLPROPAN 2 YLCARBAMATE; TERT BUTYL 1 OXO 1 [5 OXO 1 PHENYL 5 (PIPERIDIN 1 YL)PENT 3 EN 2 YLAMINO] 3 PHENYLPROPAN 2 YLCARBAMATE; TERT BUTYL 1 OXO 1 [5 OXO 1 PHENYL 5 (PYRROLIDIN 1 YL)PENT 3 EN 2 YLAMINO] 3 PHENYLPROPAN 2 YLCARBAMATE; TERT BUTYL 4 METHYL 1 (5 MORPHOLINO 5 OXO 1 PHENYLPENT 3 EN 2 YLAMINO) 1 OXOPENTAN 2 YLCARBAMATE; TERT BUTYL 4 METHYL 1 [5 (METHYLAMINO) 5 OXO 1 PHENYLPENT 3 EN 2 YLAMINO] 1 OXOPENTAN 2 YL CARBAMATE; TERT BUTYL 4 METHYL 1 OXO 1 [5 OXO 1 PHENYL 5 (PIPERIDIN 1 YL)PENT 3 EN 2 YLAMINO]PENTAN 2 YL CARBAMATE; TERT BUTYL 4 METHYL 1 OXO 1 [5 OXO 1 PHENYL 5 (PYRROLIDIN 1 YL)PENT 3 EN 2 YLAMINO]PENTAN 2 YL CARBAMATE; TERT BUTYL 5 OXO 1 PHENYL 5 (PIPERIDIN 1 YL)PENT 3 EN 2 YLCARBAMATE; TERT BUTYL 5 OXO 1 PHENYL 5 (PYRROLIDIN 1 YL)PENT 3 EN 2 YLCARBAMATE; TERT BUTYL [5 (DIMETHYLAMINO) 5 OXO 1 PHENYLPENT 3 EN 2 YLCARBAMATE; TERTB BUTYL 6 METHYL 1 (METHYLAMINO) 1 OXOHEPT 2 EN 4YLCARBAMATE; TERTB BUTYL 6 METHYL 1 OXO 1 (PYRROLIDIN 1 YL)HEPT 2 EN 4YLCARBAMATE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; MALARIA; NONHUMAN;

ANTIMALARIALS; CALPAIN; CELL PROLIFERATION; CHROMATOGRAPHY; CYSTEINE PROTEINASE INHIBITORS; FLOW CYTOMETRY; HELA CELLS; HUMANS; LEUPEPTINS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862870395     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0310-9     Document Type: Article

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