MicroRNAs become macro players in somatic cell reprogramming

Genome Medicine

Volumn 3, Issue 6, 2011, Pages

  Onder, Tamer T ^a,b   Daley, George Q ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; KRUPPEL LIKE FACTOR 4; MICRORNA; NUCLEOTIDE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; VALPROIC ACID;

BIOGENESIS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; EMBRYONIC STEM CELL; FIBROBLAST; GENE EXPRESSION; HUMAN; LENTIVIRINAE; NONHUMAN; NOTE; NUCLEAR REPROGRAMMING; ONCOGENE C MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC CELL;

EID: 84862870069     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/gm256     Document Type: Note

References (10)

1. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676. 10.1016/j.cell.2006.07.024, 16904174.
2. Plath K, Lowry WE. Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet 2011, 12:253-265. 10.1038/nrg2955, 21415849.
3. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011, 8:376-388. 10.1016/j.stem.2011.03.001, 21474102.
4. Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific microRNAs. Dev Cell 2003, 5:351-358. 10.1016/S1534-5807(03)00227-2, 12919684.
5. Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell 2008, 134:521-533. 10.1016/j.cell.2008.07.020, 2586071, 18692474.
6. Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet 2007, 39:380-385. 10.1038/ng1969, 3008549, 17259983.
7. Li Z, Yang CS, Nakashima K, Rana TM. Small RNA-mediated regulation of iPS cell generation. EMBO J 2011, 30:823-834. 10.1038/emboj.2011.2, 3049216, 21285944.
8. Melton C, Judson RL, Blelloch R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature 2010, 463:621-626. 10.1038/nature08725, 2894702, 20054295.
9. Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, Blelloch R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 2011, 29:443-448. 10.1038/nbt.1862, 21490602.
10. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008, 26:795-797. 10.1038/nbt1418, 18568017.