Value of information methods for planning and analyzing clinical studies optimize decision making and research planning

Journal of Clinical Epidemiology

Volumn 65, Issue 8, 2012, Pages 870-876

  Willan, Andrew R ^a,b   Goeree, Ron ^d,e   Boutis, Kathy ^a,c  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

Clinical decision making; Cost effectiveness studies; Net benefit; Optimal trial design; Randomized clinical trials; Value of information

Indexed keywords

ARTICLE; COST EFFECTIVENESS ANALYSIS; HEALTH CARE PLANNING; HUMAN; MEDICAL DECISION MAKING; MEDICAL INFORMATION; MEDICAL RESEARCH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SAMPLE SIZE;

ANKLE INJURIES; BRACES; COST-BENEFIT ANALYSIS; DATA INTERPRETATION, STATISTICAL; DECISION MAKING; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; SAMPLE SIZE; WRIST INJURIES;

EID: 84862866178     PISSN: 08954356     EISSN: 18785921     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2012.01.017     Document Type: Article

References (26)

1. Boutis K, Willan AR, Babyn P, Narayanan UG, Alman B, Schuh S. A randomized, controlled trial of a removable brace versus casting in children with low-risk ankle fractures. Pediatrics 2007;119: e1256-63. (Pubitemid 46871242)
2. Boutis K, Willan AR, Babyn P, Georee R, Howard A. Cast versus splint in children with minimally angulated fractures of the distal radius: a randomized controlled trial. Can Med Assoc J 2010;182:1507-12.
3. Young NL, Williams JI, Yoshida KK, Wright JG. Measurement properties of the activities scale for kids. J Clin Epidemiol 2000; 53:125-37. (Pubitemid 30151217)
4. Willan AR, Pinto EM. The expected value of information and optimal clinical trial design. Stat Med 2005;24:1791-806. Correction: Stat Med 2006;25:720.
5. Hornberger JC, Brown BW Jr, Halpern J. Designing a cost-effective clinical trial. Stat Med 1995;14:2249-59.
6. Claxton K, Posnett J. An economic approach to clinical trial design and research priority setting. Health Econ 1996;5:513-24.
7. Gittins J. Quantitative methods in the planning of pharmaceutical research. Drug Inf J 1996;30:479-87. (Pubitemid 26154148)
8. Lindley DV. The choice of sample size. Statistician 1997;46:129-38. (Pubitemid 127459032)
9. Hornberger J, Eghtesady P. The cost-benefit of a randomized trial to a health care organization. Control Clin Trials 1998;19:198-211. (Pubitemid 28191974)
10. Claxton K. The irrelevance of inference: a decision-making approach to the stochastic evaluation of health care technologies. J Health Econ 1999;18:341-64. (Pubitemid 29242816)
11. Gittins J, Pezeshk H. How large should a trial be? Statistician 2000;49:177-97.
12. Gittins J, Pezeshk H. A behavioral Bayes method for determining the size of a clinical trial. Drug Inf J 2000;34:355-63. (Pubitemid 30350988)
13. Claxton K, Thompson KM. A dynamic programming approach to the efficient design of clinical trials. J Health Econ 2001;20:797-822. (Pubitemid 32743392)
14. O'Hagan A, Stevens JW. Bayesian assessment of sample size for clinical trials of cost effectiveness. Med Decis Making 2001;21:219-30. (Pubitemid 32452766)
15. Halpern J, Brown BW Jr, Hornberger J. The sample size for a clinical trial: a Bayesian-decision theoretic approach. Stat Med 2001;20:841-58. (Pubitemid 32249084)
16. Pezeshk H, Gittins J. A fully Bayesian approach to calculating sample sizes for clinical trials with binary response. Drug Inf J 2002;36:143-50. (Pubitemid 34208210)
17. Pezeshk H. Bayesian techniques for sample size determination in clinical trials: a short review. Stat Methods Med Res 2003;12:489-504. (Pubitemid 37461098)
18. Grundy PM, Healy MJR, Rees DH. Economic choice of the amount of experimentation. J R Stat Soc A 1956;18:32-48.
19. Raiffa H, Schlaifer R. Applied statistical decision theory. Chichester, UK: John Wiley and Sons; 2000.
20. Willan AR, Cruess AF, Ballantyne M. Argon green vs krypton red laser photocoagulation of extrafoveal choroidal neovascular lesions: three-year results in age-related macular degeneration. Can J Ophthalmol 1996;31:11-7. (Pubitemid 26101420)
21. Hannah ME, Hannah WJ, Hewson SH, Hodnett ED, Saigal S, Willan AR. Term Breech Trial: a multicentre international randomised controlled trial of planned caesarean section and planned vaginal birth for breech presentation at term. Lancet 2000;356:1375-83.
22. Eckermann S, Willan AR. Expected value of information and decision making in HTA. Health Econ 2007;16:195-209. (Pubitemid 46206613)
23. Eckermann S, Willan AR. Time and EVSI wait for no patient. Value Health 2008;11:522-6.
24. Eckermann S, Willan AR. The option value of delay in health technology assessment. Med Decis Making 2008;28:300-5. (Pubitemid 351713293)
25. Willan AR, Kowgier ME. Determining optimal sample sizes for multi-stage randomized clinical trials using value of information methods. Clin Trials 2008;5:289-300.
26. Willan AR, Eckermann S. Optimal clinical trial design using value of information methods with imperfect implementation. Health Econ 2010;19:549-61.