메뉴 건너뛰기




Volumn 2, Issue 3, 2012, Pages 300-305

Pathogenesis of respiratory syncytial virus

Author keywords

[No Author keywords available]

Indexed keywords

HOST FACTOR;

EID: 84862856767     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2012.01.008     Document Type: Review
Times cited : (65)

References (55)
  • 2
    • 70349332589 scopus 로고    scopus 로고
    • Respiratory syncytial virus bronchiolitis and asthma - Insights from recent studies and implications for therapy
    • Mailaparambil B, Grychtol R, Heinzmann A: Respiratory syncytial virus bronchiolitis and asthma - insights from recent studies and implications for therapy. Inflamm Allergy Drug Targets 2009, 8:202-207.
    • (2009) Inflamm Allergy Drug Targets , vol.8 , pp. 202-207
    • Mailaparambil, B.1    Grychtol, R.2    Heinzmann, A.3
  • 3
    • 84855531866 scopus 로고    scopus 로고
    • Risk of acute otitis media in relation to acute bronchiolitis in children
    • Gomaa MA, Galal O, Mahmoud MS: Risk of acute otitis media in relation to acute bronchiolitis in children. Int J Pediatr Otorhinolaryngol 2011, 76:49-51.
    • (2011) Int J Pediatr Otorhinolaryngol , vol.76 , pp. 49-51
    • Gomaa, M.A.1    Galal, O.2    Mahmoud, M.S.3
  • 4
    • 80052702970 scopus 로고    scopus 로고
    • Respiratory syncytial virus - United States, July 2007-June 2011
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC): Respiratory syncytial virus - United States, July 2007-June 2011. MMWR Morb Mortal Wkly Rep 2011, 60:1203-1206.
    • (2011) MMWR Morb Mortal Wkly Rep , vol.60 , pp. 1203-1206
  • 5
    • 77951653074 scopus 로고    scopus 로고
    • Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis
    • Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N et al.: Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010, 375:1545-1555.
    • (2010) Lancet , vol.375 , pp. 1545-1555
    • Nair, H.1    Nokes, D.J.2    Gessner, B.D.3    Dherani, M.4    Madhi, S.A.5    Singleton, R.J.6    O'Brien, K.L.7    Roca, A.8    Wright, P.F.9    Bruce, N.10
  • 6
    • 81555228664 scopus 로고    scopus 로고
    • Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years
    • Collins PL, Melero JA: Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years. Virus Res 2011, 162:80-99.
    • (2011) Virus Res , vol.162 , pp. 80-99
    • Collins, P.L.1    Melero, J.A.2
  • 8
    • 24044538547 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in elderly adults
    • DOI 10.2165/00002512-200522070-00004
    • Falsey AR, Walsh EE: Respiratory syncytial virus infection in elderly adults. Drugs Aging 2005, 22:577-587. (Pubitemid 41214551)
    • (2005) Drugs and Aging , vol.22 , Issue.7 , pp. 577-587
    • Falsey, A.R.1    Walsh, E.E.2
  • 9
  • 10
    • 71949099031 scopus 로고    scopus 로고
    • From the American Academy of Pediatrics: Policy statements - Modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections
    • Committee on Infectious Diseases
    • Committee on Infectious Diseases: From the American Academy of Pediatrics: Policy statements - modified recommendations for use of palivizumab for prevention of respiratory syncytial virus infections. Pediatrics 2009, 124:1694-1701.
    • (2009) Pediatrics , vol.124 , pp. 1694-1701
  • 11
    • 61749100105 scopus 로고    scopus 로고
    • Infant exposure to fine particulate matter and traffic and risk of hospitalization for RSV bronchiolitis in a region with lower ambient air pollution
    • Karr CJ, Rudra CB, Miller KA, Gould TR, Larson T, Sathyanarayana S, Koenig JQ: Infant exposure to fine particulate matter and traffic and risk of hospitalization for RSV bronchiolitis in a region with lower ambient air pollution. Environ Res 2009, 109:321-327.
    • (2009) Environ Res , vol.109 , pp. 321-327
    • Karr, C.J.1    Rudra, C.B.2    Miller, K.A.3    Gould, T.R.4    Larson, T.5    Sathyanarayana, S.6    Koenig, J.Q.7
  • 12
    • 16844366732 scopus 로고    scopus 로고
    • Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    • DOI 10.1542/peds.2004-0059
    • Bradley JP, Bacharier LB, Bonfiglio J, Schechtman KB, Strunk R, Storch G, Castro M: Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy. Pediatrics 2005, 115:e7-e14. (Pubitemid 43046257)
    • (2005) Pediatrics , vol.115 , Issue.1
    • Bradley, J.P.1    Bacharier, L.B.2    Bonfiglio, J.3    Schechtman, K.B.4    Strunk, R.5    Storch, G.6    Castro, M.7
  • 14
    • 33845709027 scopus 로고    scopus 로고
    • The histopathology of fatal untreated human respiratory syncytial virus infection
    • DOI 10.1038/modpathol.3800725, PII 3800725
    • Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS: The histopathology of fatal untreated human respiratory syncytial virus infection. Mod Pathol 2007, 20:108-119. (Pubitemid 44967956)
    • (2007) Modern Pathology , vol.20 , Issue.1 , pp. 108-119
    • Johnson, J.E.1    Gonzales, R.A.2    Olson, S.J.3    Wright, P.F.4    Graham, B.S.5
  • 15
    • 20744438629 scopus 로고    scopus 로고
    • Growth of respiratory syncytial virus in primary epithelial cells from the human respiratory tract
    • DOI 10.1128/JVI.79.13.8651-8654.2005
    • Wright PF, Ikizler MR, Gonzales RA, Carroll KN, Johnson JE, Werkhaven JA: Growth of respiratory syncytial virus in primary epithelial cells from the human respiratory tract. J Virol 2005, 79:8651-8654. (Pubitemid 40853565)
    • (2005) Journal of Virology , vol.79 , Issue.13 , pp. 8651-8654
    • Wright, P.F.1    Ikizler, M.R.2    Gonzales, R.A.3    Carroll, K.N.4    Johnson, J.E.5    Werkhaven, J.A.6
  • 16
    • 80053973672 scopus 로고    scopus 로고
    • Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells
    • Wu W, Munday DC, Howell G, Platt G, Barr JN, Hiscox JA: Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells. J Virol 2011, 85:10300-10309.
    • (2011) J Virol , vol.85 , pp. 10300-10309
    • Wu, W.1    Munday, D.C.2    Howell, G.3    Platt, G.4    Barr, J.N.5    Hiscox, J.A.6
  • 18
    • 80052422367 scopus 로고    scopus 로고
    • Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
    • A positive correlation between duration of clinical disease and RSV viral load was demonstrated. These observations challenge the immunopathology- based pathogenesis paradigm, and suggest that (early) treatment with antiviral agents might improve subsequent morbidity
    • El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP: Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 2011, 204:996-1002. A positive correlation between duration of clinical disease and RSV viral load was demonstrated. These observations challenge the immunopathology- based pathogenesis paradigm, and suggest that (early) treatment with antiviral agents might improve subsequent morbidity.
    • (2011) J Infect Dis , vol.204 , pp. 996-1002
    • El Saleeby, C.M.1    Bush, A.J.2    Harrison, L.M.3    Aitken, J.A.4    Devincenzo, J.P.5
  • 20
    • 79958104622 scopus 로고    scopus 로고
    • Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice
    • Several clinical isolates were tested and shown to induce variable pathogenesis in BALB/c mice. A mouse model that shows characteristic RSV pathogenesis was developed with one of these isolates
    • Stokes KL, Chi MH, Sakamoto K, Newcomb DC, Currier MG, Huckabee MM, Lee S, Goleniewska K, Pretto C, Williams JV et al.: Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice. J Virol 2011, 85:5782-5793. Several clinical isolates were tested and shown to induce variable pathogenesis in BALB/c mice. A mouse model that shows characteristic RSV pathogenesis was developed with one of these isolates.
    • (2011) J Virol , vol.85 , pp. 5782-5793
    • Stokes, K.L.1    Chi, M.H.2    Sakamoto, K.3    Newcomb, D.C.4    Currier, M.G.5    Huckabee, M.M.6    Lee, S.7    Goleniewska, K.8    Pretto, C.9    Williams, J.V.10
  • 23
    • 64049090424 scopus 로고    scopus 로고
    • Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I
    • Ling Z, Tran KC, Teng MN: Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I. J Virol 2009, 83:3734-3742.
    • (2009) J Virol , vol.83 , pp. 3734-3742
    • Ling, Z.1    Tran, K.C.2    Teng, M.N.3
  • 24
    • 33846815515 scopus 로고    scopus 로고
    • Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growth
    • DOI 10.1128/JVI.01420-06
    • Bitko V, Shulyayeva O, Mazumder B, Musiyenko A, Ramaswamy M, Look DC, Barik S: Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growth. J Virol 2007, 81:1786-1795. (Pubitemid 46214452)
    • (2007) Journal of Virology , vol.81 , Issue.4 , pp. 1786-1795
    • Bitko, V.1    Shulyayeva, O.2    Mazumder, B.3    Musiyenko, A.4    Ramaswamy, M.5    Look, D.C.6    Barik, S.7
  • 25
    • 57349108091 scopus 로고    scopus 로고
    • The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes
    • Bukreyev A, Yang L, Fricke J, Cheng L, Ward JM, Murphy BR, Collins PL: The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes. J Virol 2008, 82:12191-12204.
    • (2008) J Virol , vol.82 , pp. 12191-12204
    • Bukreyev, A.1    Yang, L.2    Fricke, J.3    Cheng, L.4    Ward, J.M.5    Murphy, B.R.6    Collins, P.L.7
  • 28
    • 45749111409 scopus 로고    scopus 로고
    • Regulation of immunity to respiratory syncytial virus by dendritic cells, toll-like receptors, and notch
    • DOI 10.1089/vim.2007.0110
    • Lukacs NW, Smit JJ, Schaller MA, Lindell DM: Regulation of immunity to respiratory syncytial virus by dendritic cells, tolllike receptors, and notch. Viral Immunol 2008, 21:115-122. (Pubitemid 351873371)
    • (2008) Viral Immunology , vol.21 , Issue.2 , pp. 115-122
    • Lukacs, N.W.1    Smit, J.J.2    Schaller, M.A.3    Lindell, D.M.4
  • 29
    • 79955758958 scopus 로고    scopus 로고
    • Respiratory syncytial virus interferon antagonist NS1 protein suppresses and skews the human T lymphocyte response
    • + T cells and Th17 cells, and to promote proliferation and activation of Th2 cells. Evidence for downregulation of maturation by NS1 and NS2 was provided
    • + T cells and Th17 cells, and to promote proliferation and activation of Th2 cells. Evidence for downregulation of maturation by NS1 and NS2 was provided.
    • (2011) PLoS Pathogens , vol.7
    • Munir, S.1    Hillyer, P.2    Le Nouen, C.3    Buchholz, U.J.4    Rabin, R.L.5    Collins, P.L.6    Bukreyev, A.7
  • 30
    • 79959837578 scopus 로고    scopus 로고
    • Low CCR7-mediated migration of human monocyte derived dendritic cells in response to human respiratory syncytial virus and human metapneumovirus
    • RSV infection of human monocyte-derived dendritic cells (mo-DCs) led to reduced increase in CCR7 expression, and mo-DCs stimulated with RSV migrated inefficiently to CCL19. This suggests that impaired migration of RSV-stimulated DCs to lymphatic tissue contributes to impaired adaptive responses to RSV
    • Le Nouen C, Hillyer P, Winter CC, McCarty T, Rabin RL, Collins PL, Buchholz UJ: Low CCR7-mediated migration of human monocyte derived dendritic cells in response to human respiratory syncytial virus and human metapneumovirus. PLoS Pathogens 2011, 7:e1002105. RSV infection of human monocyte-derived dendritic cells (mo-DCs) led to reduced increase in CCR7 expression, and mo-DCs stimulated with RSV migrated inefficiently to CCL19. This suggests that impaired migration of RSV-stimulated DCs to lymphatic tissue contributes to impaired adaptive responses to RSV.
    • (2011) PLoS Pathogens , vol.7
    • Le Nouen, C.1    Hillyer, P.2    Winter, C.C.3    McCarty, T.4    Rabin, R.L.5    Collins, P.L.6    Buchholz, U.J.7
  • 32
    • 15544362414 scopus 로고    scopus 로고
    • Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections
    • DOI 10.1086/428589
    • Gill MA, Palucka AK, Barton T, Ghaffar F, Jafri H, Banchereau J, Ramilo O: Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections. J Infect Dis 2005, 191:1105-1115. (Pubitemid 40404369)
    • (2005) Journal of Infectious Diseases , vol.191 , Issue.7 , pp. 1105-1115
    • Gill, M.A.1    Palucka, A.K.2    Barton, T.3    Ghaffar, F.4    Jafri, H.5    Banchereau, J.6    Ramilo, O.7
  • 33
    • 80051625953 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in human bone marrow stromal cells
    • Human bone marrow stromal cells (BMSCs) were identified as a novel target for RSV, both in vivo and ex vivo. RSV infection of BMSCs resulted in structural and functional changes, which may influence the pathogenesis
    • Rezaee F, Gibson LF, Piktel D, Othumpangat S, Piedimonte G: Respiratory syncytial virus infection in human bone marrow stromal cells. Am J Respir Cell Mol Biol 2011, 45:277-286. Human bone marrow stromal cells (BMSCs) were identified as a novel target for RSV, both in vivo and ex vivo. RSV infection of BMSCs resulted in structural and functional changes, which may influence the pathogenesis.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 277-286
    • Rezaee, F.1    Gibson, L.F.2    Piktel, D.3    Othumpangat, S.4    Piedimonte, G.5
  • 34
    • 79952539202 scopus 로고    scopus 로고
    • Prevention of serious respiratory syncytial virus-related illness. I: Disease pathogenesis and early attempts at prevention
    • Groothuis JR, Hoopes JM, Jessie VG: Prevention of serious respiratory syncytial virus-related illness. I: Disease pathogenesis and early attempts at prevention. Adv Ther 2011, 28:91-109.
    • (2011) Adv Ther , vol.28 , pp. 91-109
    • Groothuis, J.R.1    Hoopes, J.M.2    Jessie, V.G.3
  • 35
    • 79957891834 scopus 로고    scopus 로고
    • Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis
    • An analysis of cord blood vitamin D levels showed that vitamin D deficiency is correlated with increased risk of RSV LRTI in the first year of life This suggests vitamin D supplementation during pregnancy as a strategy to prevent RSV LRTI
    • Belderbos ME, Houben ML, Wilbrink B, Lentjes E, Bloemen EM, Kimpen JL, Rovers M, Bont L: Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics 2011, 127:e1513-e1520. An analysis of cord blood vitamin D levels showed that vitamin D deficiency is correlated with increased risk of RSV LRTI in the first year of life This suggests vitamin D supplementation during pregnancy as a strategy to prevent RSV LRTI.
    • (2011) Pediatrics , vol.127
    • Belderbos, M.E.1    Houben, M.L.2    Wilbrink, B.3    Lentjes, E.4    Bloemen, E.M.5    Kimpen, J.L.6    Rovers, M.7    Bont, L.8
  • 36
    • 54249119031 scopus 로고    scopus 로고
    • Human genetic factors and respiratory syncytial virus disease severity
    • Miyairi I, DeVincenzo JP: Human genetic factors and respiratory syncytial virus disease severity. Clin Microbiol Rev 2008, 21:686-703.
    • (2008) Clin Microbiol Rev , vol.21 , pp. 686-703
    • Miyairi, I.1    DeVincenzo, J.P.2
  • 37
    • 17044371439 scopus 로고    scopus 로고
    • Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis
    • McNamara PS, Flanagan BF, Hart CA, Smyth RL: Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis 2005, 191:1225-1232.
    • (2005) J Infect Dis , vol.191 , pp. 1225-1232
    • McNamara, P.S.1    Flanagan, B.F.2    Hart, C.A.3    Smyth, R.L.4
  • 39
    • 0141636306 scopus 로고    scopus 로고
    • Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis
    • DOI 10.1136/adc.88.10.922
    • McNamara PS, Ritson P, Selby A, Hart CA, Smyth RL: Bronchoalveolar lavage cellularity in infants with severe respiratory syncytial virus bronchiolitis. Arch Dis Child 2003, 88:922-926. (Pubitemid 37194053)
    • (2003) Archives of Disease in Childhood , vol.88 , Issue.10 , pp. 922-926
    • McNamara, P.S.1    Ritson, P.2    Selby, A.3    Hart, C.A.4    Smyth, R.L.5
  • 42
    • 80053438410 scopus 로고    scopus 로고
    • RSV 2010: Recent advances in research on respiratory syncytial virus and other pneumoviruses
    • van Bleek GM, Osterhaus AD, de Swart RL: RSV 2010: recent advances in research on respiratory syncytial virus and other pneumoviruses. Vaccine 2011, 29:7285-7291.
    • (2011) Vaccine , vol.29 , pp. 7285-7291
    • Van Bleek, G.M.1    Osterhaus, A.D.2    De Swart, R.L.3
  • 44
    • 77956913784 scopus 로고    scopus 로고
    • Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection
    • A rapid accumulation of regulatory T-cells (Tregs) in the mediastinal lymph nodes and lungs of RSV infected mice was shown. In vivo depletion of Tregs before RSV infection led to delayed virus clearance and enhanced disease. This indicates that pulmonary Tregs play a critical role in limiting immunopathology during acute RSV infection
    • Fulton RB, Meyerholz DK, Varga SM: Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol 2010, 185:2382-2392. A rapid accumulation of regulatory T-cells (Tregs) in the mediastinal lymph nodes and lungs of RSV infected mice was shown. In vivo depletion of Tregs before RSV infection led to delayed virus clearance and enhanced disease. This indicates that pulmonary Tregs play a critical role in limiting immunopathology during acute RSV infection.
    • (2010) J Immunol , vol.185 , pp. 2382-2392
    • Fulton, R.B.1    Meyerholz, D.K.2    Varga, S.M.3
  • 45
    • 77956635170 scopus 로고    scopus 로고
    • CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection
    • In increase in natural Treg numbers in the bronchoalveolar lavage fluid, lung, mediastinal lymph nodes, and spleen was demonstrated in RSVinfected mice. Depletion of Tregs led to increased weight loss. The Tregs were shown to play a critical role in regulating both innate and adaptive responses late during RSV infection
    • Lee DC, Harker JA, Tregoning JS, Atabani SF, Johansson C, Schwarze J, Openshaw PJ: CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol 2010, 84:8790-8798. In increase in natural Treg numbers in the bronchoalveolar lavage fluid, lung, mediastinal lymph nodes, and spleen was demonstrated in RSVinfected mice. Depletion of Tregs led to increased weight loss. The Tregs were shown to play a critical role in regulating both innate and adaptive responses late during RSV infection.
    • (2010) J Virol , vol.84 , pp. 8790-8798
    • Lee, D.C.1    Harker, J.A.2    Tregoning, J.S.3    Atabani, S.F.4    Johansson, C.5    Schwarze, J.6    Openshaw, P.J.7
  • 46
    • 63149132590 scopus 로고    scopus 로고
    • Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities
    • Ruckwardt TJ, Bonaparte KL, Nason MC, Graham BS: Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J Virol 2009, 83:3019-3028.
    • (2009) J Virol , vol.83 , pp. 3019-3028
    • Ruckwardt, T.J.1    Bonaparte, K.L.2    Nason, M.C.3    Graham, B.S.4
  • 47
    • 80052508971 scopus 로고    scopus 로고
    • IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease
    • Increased IL-6 and IL-17 levels were detected in tracheal aspirate samples from severely ill infants with RSV infection. A role for IL-17 in RSV pathogenesis was subsequently established in the mouse model
    • Mukherjee S, Lindell DM, Berlin AA, Morris SB, Shanley TP, Hershenson MB, Lukacs NW: IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease. Am J Pathol 2011, 179:248-258. Increased IL-6 and IL-17 levels were detected in tracheal aspirate samples from severely ill infants with RSV infection. A role for IL-17 in RSV pathogenesis was subsequently established in the mouse model.
    • (2011) Am J Pathol , vol.179 , pp. 248-258
    • Mukherjee, S.1    Lindell, D.M.2    Berlin, A.A.3    Morris, S.B.4    Shanley, T.P.5    Hershenson, M.B.6    Lukacs, N.W.7
  • 48
    • 78650207448 scopus 로고    scopus 로고
    • The use of a neonatal mouse model to study respiratory syncytial virus infections
    • Cormier SA, You D, Honnegowda S: The use of a neonatal mouse model to study respiratory syncytial virus infections. Expert Rev Anti-infective Ther 2010, 8:1371-1380.
    • (2010) Expert Rev Anti-infective Ther , vol.8 , pp. 1371-1380
    • Cormier, S.A.1    You, D.2    Honnegowda, S.3
  • 49
    • 43849098060 scopus 로고    scopus 로고
    • Pneumonia virus of mice: Severe respiratory infection in a natural host
    • Rosenberg HF, Domachowske JB: Pneumonia virus of mice: severe respiratory infection in a natural host. Immunol Lett 2008, 118:6-12.
    • (2008) Immunol Lett , vol.118 , pp. 6-12
    • Rosenberg, H.F.1    Domachowske, J.B.2
  • 50
    • 41249088135 scopus 로고    scopus 로고
    • Bovine respiratory syncytial virus infection: Immunopathogenic mechanisms
    • Gershwin LJ: Bovine respiratory syncytial virus infection: immunopathogenic mechanisms. Anim Health Res Rev 2007, 8:207-213.
    • (2007) Anim Health Res Rev , vol.8 , pp. 207-213
    • Gershwin, L.J.1
  • 51
    • 77956807582 scopus 로고    scopus 로고
    • Agedependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence
    • Antonis AF, de Jong MC, van der Poel WH, van der Most RG, Stockhofe-Zurwieden N, Kimman T, Schrijver RS: Agedependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence. J Gen Virol 2011, 91(Pt 10):2497-2506.
    • (2011) J Gen Virol , vol.91 , Issue.PART 10 , pp. 2497-2506
    • Antonis, A.F.1    De Jong, M.C.2    Van Der Poel, W.H.3    Van Der Most, R.G.4    Stockhofe-Zurwieden, N.5    Kimman, T.6    Schrijver, R.S.7
  • 52
    • 78650667617 scopus 로고    scopus 로고
    • Respiratory syncytial virus is associated with an inflammatory response in lungs and architectural remodeling of lung-draining lymph nodes of newborn lambs
    • A detailed characterization of the pathology induced by RSV A2 in newborn lambs demonstrated moderate clinical disease with increased virus titers, accumulation of macrophages, CD4+ and CD8+ T cells, and a transcriptional response of genes involved in inflammation, chemotaxis, and interferon response
    • Sow FB, Gallup JM, Olivier A, Krishnan S, Patera AC, Suzich J, Ackermann MR: Respiratory syncytial virus is associated with an inflammatory response in lungs and architectural remodeling of lung-draining lymph nodes of newborn lambs. Am J Physiol Lung Cell Mol Physiol 2011, 300:L12-L24. A detailed characterization of the pathology induced by RSV A2 in newborn lambs demonstrated moderate clinical disease with increased virus titers, accumulation of macrophages, CD4+ and CD8+ T cells, and a transcriptional response of genes involved in inflammation, chemotaxis, and interferon response.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300
    • Sow, F.B.1    Gallup, J.M.2    Olivier, A.3    Krishnan, S.4    Patera, A.C.5    Suzich, J.6    Ackermann, M.R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.