A new lupane-type triterpene from the seeds of panax ginseng with its inhibition of NF-κB

Archives of Pharmacal Research

Volumn 35, Issue 4, 2012, Pages 647-651

  Kim, Jeong Ah ^a,b   Son, Jeong Hyun ^a   Yang, Seo Young ^a   Song, Seok Bean ^a   Song, Gyu Yong ^a   Kim, Young Ho ^a  

^a Chungnam National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

COX 2; INOS; Lupane type triterpene NF B; Panax ginseng; Seeds

Indexed keywords

3BETA FERULOYLOXY 16BETA HYDROXYLUP 20(29) ENE; CYCLOOXYGENASE 2; GINSENG EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; TRITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; GENE TARGETING; GENETIC TRANSFECTION; GINSENG; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT SEED; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PANAX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEEDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANSFECTION; TRITERPENES;

EID: 84862853721     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0408-0     Document Type: Article

References (7)

1. Hwang, B. Y., Chai, H. B., Kardono, L. B., Riswan, S., Farnsworth, N. R., Cordell, G. A., Pezzuto, J. M., and Kinghorn, A. D., Cytotoxic triterpenes from the twigs of Celtis philippinensis. Phytochemistry, 62, 197-201 (2003).
2. Kim, K. K., Park, K. S., Song, S. B., and Kim, K. E., Up regulation of GW112 gene by NF-kappaB promotes an antiapoptotic property in gastric cancer cells. Mol. Carcinog., 49, 259-270 (2010).
3. Kim, J. A., Yang, S. Y., Song, S. B., and Kim, Y. H., Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities. Arch. Pharm. Res., 34, 1347-1351 (2011).
4. Lee, S, Y., Kim, Y. K., Park, N. I., Kim, C. S., Lee, C. Y., and Park, S. U., Chemical constituents and biological activities of the berry of Panax ginseng. J. Med. Plants Res., 4, 349-353 (2010).
5. Park, J. D., Rhee, D. K., and Lee, Y. H., Biological activities and chemistry of saponins from Panax ginseng C. A. Meyer. Phytochem. Rev., 4, 159-175 (2005).
6. Tung, N. H., Cho, K., Kim, J. A., Song, G. Y., and Kim, Y. H., Dammarane-type glycosides from the steamed flowerbuds of Panax ginseng. Bull. Korean Chem. Soc., 31, 1381-1384 (2010).
7. Yoshikawa, M., Sugimoto, S., Nakamura, S., Sakumae, H., and Matsuda, H., Medicinal flowers. XVI. New dammarane-type triterpene tetraglycosides and gastroprotective principles from flower buds of Panax ginseng. Chem. Pharm. Bull. (Tokyo), 55, 1034-1038 (2007).