Association between immune competence and metabolic parameters in obesity

Trends in Medical Research

Volumn 7, Issue 2, 2012, Pages 53-61

  Abd El Hafez, Hala ^a   Abd El Aziz, Sherin M ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

Flow cytometry; Metabolic factors; Natural killer; Obesity; T lymphocyte

Indexed keywords

CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; LEUKOCYTE COUNT; MALE; NATURAL KILLER CELL; OBESITY; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; T LYMPHOCYTE SUBPOPULATION; WAIST CIRCUMFERENCE;

EID: 84862852212     PISSN: 18193587     EISSN: 21516065     Source Type: Journal    
DOI: 10.3923/tmr.2012.53.61     Document Type: Article

References (42)

1. Assal, H.S., M. Fath-AIlah and A. Elsherbiny, 2007. Serum leptin and adiponectin in obese diabetic and non-diabetic. J. Medical Sci., 7: 865-869.
2. Barnett, J.B., M.N. Woods, B. Rosner, C. McCormack, L. Floyd, C. Longcope and S.L. Gorbach, 2002. Waist-to-hip ratio, body mass index and sex hormone levels associated with breast cancer risk in premenopausal Caucasian women. J. Medical Sci., 2: 170-176.
3. Bucolo, G. and H. David, 1973. Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem., 19: 476-482.
4. Calle, E.E., C. Rodriguez, K. Walker-Thurmond and M.J. Thun, 2003. Overweight, obesity and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med., 348: 1625-1638.
5. Dixon, J.B. and P.E. O' Brien, 2006. Obesity and the white blood cell count: Changes with sustained weight loss. Obes. Surg., 16: 251-257.
6. Dossett, L.A., L.A. Dageforde, B.R. Swenson, R. Metzger, H. Bonatti, R.G. Sawyer and A.K. May, 2009. Obesity and site-specific nosocomial infection risk in the intensive care unit. Surg. Infect., 10: 137-142.
7. Falagas, M.E. and M. Kompoti, 2006. Obesity and infection. Lancet Infect Dis., 6: 438-446.
8. Flegal, K.M., B.I. Graubard, D.F. Williamson and M.H. Gail, 2007. Cause-specific excess deaths associated with underweight, overweight and obesity. JAMA, 298: 2028-2037.
9. Friedewald, W.T., R.I. Levy and D.S. Fredrickson, 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem, 18: 499-502.
10. Hanley, A.J., R. Retnakaran, Y. Qi, H.C. Gerstein and B. Perkins et al., 2009. Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects. J. Clin. Endocrinol. Metab., 94: 3824-3832.
11. Home, B.D., J.L. Anderson, J.M. John, A. Weaver and T.L. Bair et al., 2005. Which white blood cell subtypes predict increased cardiovascular risk?. J. Am. Coll. Cardiol., 45: 1638-1643.
12. Hotamisligil, G.S., 2006. Review article inflammation and metabolic disorders. Nature, 444: 860-867.
13. Jameson, S.C. and D. Masopust, 2009. Diversity in T cell memory: An embarrassment of riches. Immunity, 31: 859-871.
14. Janeway, C.A., P. Travers, M. Walport and M.J. Shlomchik, 2005. Immunobiology: The Immune System in Health and Disease. 6th Edn., Garland Science Publishing Inc., New York.
15. Karlsson, E.A. and M.A. Beck, 2010. The burden of obesity on infectious disease. Exp. Biol. Med., 235: 1412-1424.
16. Kim, D.J., J.H. Noh, B.W. Lee, Y.H. Choi and J.H. Chung et al, 2008. The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population. J. Korean Med. Sci., 23: 193-198.
17. Li, Z, M.J. Soloski and A.M. Diehl, 2005. Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology, 42: 880-885.
18. Lynch, L.A, J.M. O' Connell, A.K. Kwasnik, T.J. Cawood, C. OTarrelly and D.B. O'Shea, 2009. Are natural killer cells protecting the metabolically healthy obese patient. Obesity, 17: 601-605.
19. Maclver, N.J, S.R. Jacobs, H.L. Wieman, J.A. Wofford, J.L. Coloff and J.C. Rathmell, 2008. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J. Leukoc. Biol, 84: 949-957.
20. Marti, A, A. Marcos and J.A. Martinez, 2001. Obesity and immune function relationships. Obes. Rev, 2: 131-140.
21. Matthews, D.R, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher and R.C. Turner, 1985. Homeostasis model assessment: Insulin resistance and a-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia, 28: 412-419.
22. Naito, H. and A. Kaplan, 1984. Clinical Chemistry. The C.V. Mosby Co, St Louis, Toronto, Princeton, pp: 1194-1206, 437.
23. Naito, H.K, 2003. Coronary Artery Disease and Disorders of Lipid Metabolism. In: Clinical Chemistry: Theory, Analysis, Correlation, Kaplan, L.A, A.J. Pesce and S.C. Kazmierczak (Eds.). 4th Edn. Mosby Inc., St Louis, USA, ISBN-13: 9780323017169, pp: 603.
24. Nikolajczyk, B.S, M. Jagannathan-Bogdan, H. Shin and R. Gyurko, 2011. State of the union between metabolism and immune system in type 2 diabetes. Genes Immun, 12: 239-250.
25. Otero, M, R. Lago, R. Gomez, C. Dieguez, F. Lago, J. Gomez-Reino and O. Gualillo, 2006. Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Reumatology, 45: 944-950.
26. Owiredu, W.K.B.A, S. Donkor, B.W. Addai and N. Amidu, 2009. Serum lipid profile of breast cancer patients. Pak. J. Biol. Sci, 12: 332-338.
27. O' Rourke, R.W, T. Kay, M.H. Scholz, B. Diggs, B.A. Jobe, D.M. Lewinsohn and A.C. Bakke, 2005. Alterations in T-cell subset frequency in peripheral blood in obesity. Obes. Surg., 15: 1463-1468.
28. O' Shea, D., T.J. Cawood, C. O'Farrely and L. Lynch, 2010. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One, Vol. 5, No. 1. 10.1371/journal.pone. 0008660.
29. Pacifico, L., L. Di Renzo, C. Anania, J.F. Osborn, F. Ippoliti, E. Schiavo and C. Chiesa, 2006. Increased T-helper interferon-gamma-secreting cells in obese children. Eur. J. Endocrinol., 154:691-697.
30. Pearce, E.L., 2010. Metabolism in T cell activation and differentiation. Curr. Opin. Immunol., 22: 314-320.
31. Rudd, P.M., T. Elliott, P. Cresswell, LA. Wilson and R.A. Dwek, 2001. Glycosylation and the immune system. Science, 291: 2370-2376.
32. Schelbert, KB., 2009. Comorbidities of obesity. Prim Care, 36: 271-285.
33. Scott, P. and G. Trinchieri, 1995. The role of natural killer cells in host-parasite interactions. Curr. Opm. Immunol., 7: 34-40.
34. Smith, A.G., P.A. Sheridan, J.B. Harp and M.A. Beck, 2007. Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J. Nutr., 137: 1236-1243.
35. Surender, J., V. Mohan, M.M. Rao, S. Babu and V. Aravindhan, 2011. Increased levels of both Thl and Th2 cytokines in subjects with metabolic syndrome (CURES-103). Diabetes Technol. Ther., 13: 477-482.
36. Tanaka, S., F. Isoda, Y. Ishihara, M. Kimura and T. Yamakawa, 2001. T lymphopaenia in relation to body mass indexand TNF-alpha in human obesity: Adequate weight reduction can be corrective. Clin. Endocrinol., 54: 347-354.
37. Tanigawa, T., H. Iso, K. Yamagishi, I. Muraki and N. Kawamura et al., 2004. Association of lymphocyte sub-populations with clustered features of metabolic syndrome in middle-aged Japanese men. Atherosclerosis, 173: 295-300.
38. Temple, R.C., P.M.S. Clark and C.N. Hales, 1992. Measurement of insulin secretion in type 2 diabetes: Problems and pitfalls. Diabetic Med., 9: 503-512.
39. Trinder, P., 1969. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem., 6: 24-27.
40. Wellen, K.E. and G.S. Hotamisligil, 2005. Inflammation, stress and diabetes. J. Clin. Invest., 115: 1111-1119.
41. Womack, J., P.C. Tien, J. Feldman, J.H. Shin and K. Fennie et al., 2007. Obesity and immune cell counts in women. Metabolism, 56: 998-1004.
42. Yang, H., Y.H. Youm, B. Vandanmagsar, J. Rood, KG. Kumar, A.A. Butler and V.D. Dixit, 2009. Obesity accelerates thymic aging. Blood, 114: 3803-3812.