Differential expression of estrogen receptor α and β transcripts in tissues and in primary culture cells from pubertal gynecomastia

Journal of Endocrinological Investigation

Volumn 35, Issue 2, 2012, Pages 150-153

  Nicoletti, G F ^a   D'Andrea, F ^a   Ferraro, G ^a   Romanucci, V ^a   Renzullo, A ^a   Accardo, G ^a   Sacco, V ^a   Pannone, G ^b   Bellastella, A ^a   Pasquali, D ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

Author keywords

Anti estrogens; ER ; ER ; Gynecomastia; Pubertal gynecomastia

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA;

ADOLECSCENT DISEASE; ADOLESCENT; ARTICLE; BREAST EPITHELIUM; BREAST RECONSTRUCTION; CLINICAL DECISION MAKING; GYNECOMASTIA; HUMAN; MALE; PROTEIN EXPRESSION; PUBERTAL GYNECOMASTIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL;

ADOLESCENT; CELLS, CULTURED; CHILD; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION REGULATION; GYNECOMASTIA; HUMANS; MALE; PRIMARY CELL CULTURE; PUBERTY; RNA, MESSENGER; STROMAL CELLS; TISSUE DISTRIBUTION;

EID: 84862849192     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7737     Document Type: Article

References (30)

1. Johnson RE, Murad MH. Gynecomastia: pathophysiology, evaluation, and management. Mayo Clin Proc 2009, 84: 1010-5.
2. Einav-Bachar R, Phillip M, Aurbach-Klipper Y, Lazarm L. Prepubertal gynaecomastia: aetiology, course and outcome. Clin Endocrinol (Oxf) 2004, 61: 55-60.
3. Lazala C, Saenger P. Pubertal gynecomastia. J Pediatr Endocrinol Metab 2002, 15: 553-60.
4. Korenman SG. The endocrinology of the abnormal male breast. Ann N Y Acad Sci 1985, 65: 400-8.
5. Ribeiro G. Male breast carcinoma - a review of 301 cases from the Christie Hospital & Holt Radium Institute, Manchester. Br J Cancer 1985, 51: 115-9.
6. Zhao C, Dahlman-Wright K, Gustafsson JA. Estrogen receptor beta: an overview and update. Nucl Recept Signal 2008, 6: e003.
7. Sasano H, Kimura M, Shizawa S, Kimura N, Nagura H. Aromatase and steroid receptors in gynecomastia and male breast carcinoma: an immunohistochemical study. J Clin Endocrinol Metab 1996, 81: 3063-7.
8. Shoker BS, Jarvis C, Clarke RB, et al. Abnormal regulation of the oestrogen receptor in benign breast lesions. J Clin Pathol 2000, 53: 778-83.
9. Andersen J, Orntoft TF, Andersen JA, Poulsen HS. Gynecomastia. Immunohistochemical demonstration of estrogen receptors. Acta Pathol Microbiol Immunol Scand 1987, 95: 263-7.
10. Gikas P, Mokbel K. Management of gynaecomastia: an update. Int J Clin Pract 2007, 61: 1209-15.
11. Hanavadi S, Banerjee D, Monypenny IJ, Mansel RE. The role of tamoxifen in the management of gynaecomastia. Breast 2006, 15: 276-80.
12. Ting AC, Chow LW, Leung YF Comparison of tamoxifen with danazol in the management of idiopathic gynecomastia. Am Surg 2000, 66: 38-40.
13. Lawrence SE, Faught KA, Vethamuthu J, Lawson ML. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. J Pediatr 2004, 145: 71-6.
14. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 1976, 51: 170-9.
15. Zachmann M, Prader A, Kind HP, Häfliger H, Budliger H. Testicular volume during adolescence. Cross-sectional and longitudinal studies. Helv Paediatr Acta 1974, 29: 61-72.
16. Pasquali D, Rossi V, Esposito D, et al. Loss of estrogen receptor beta expression in malignant human prostate cells in primary cultures and in prostate cancer tissues. J Clin Endocrinol Metab 2001, 86: 2051-5.
17. Pasquali D, Rossi V, Conzo G, et al. Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cells. J Mol Endocrinol 2008, 40: 263-71.
18. Coen P, Kulin H, Ballantine T, et al. An aromatase-producing sexcord tumor resulting in prepubertal gynecomastia. N Engl J Med 1991, 324: 317-22.
19. Hochberg Z, Even L, Zadik Z. Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. J Pediatr 1991, 118: 258-60.
20. Berensztein E, Belgorosky A, de Dávila MT, Rivarola MA. Testicular steroid biosynthesis in a boy with a large cell calcifying Sertoli cell tumor producing prepubertal gynecomastia. Steroids 1995, 60: 220-5.
21. Watanabe T, Yasuda T, Noda H, et al. Estrogen secreting adrenal adenocarcinoma in an 18-month-old boy: aromatase activity, protein expression, mRNA and utilization of gonadal type promoter. Endocr J 2000, 47: 723-30.
22. Einav-Bachar R, Phillip M, Aurbach-Klipper Y, Lazar L. Prepubertal gynaecomastia: aetiology, course and outcome. Clin Endocrinol 2004, 61: 55-60.
23. Cordova A, Moschella F. Algorithm for clinical evaluation and surgical treatment of gynaecomastia. J Plast Reconstr Aesthet Surg 2008, 61: 41-9.
24. Ma NS, Geffner ME. Gynecomastia in prepubertal and pubertal men. Curr Opin Pediatr 2008, 20: 465-70.
25. Gustafsson JA. What pharmacologists can learn from recent advances in estrogen signalling. Trends Pharmacol Sci 2003, 24: 479-85.
26. Korach KS Estrogen receptor knock-out mice: molecular and endocrine phenotypes. J Soc Gynecol Investig 2000, 7 (Suppl): S16-7.
27. Couse JF, Curtis Hewitt S, Korach KS. Receptor null mice reveal contrasting roles for estrogen receptor alpha and beta in reproductive tissues. J Steroid Biochem Mol Biol 2000, 74: 287-96.
28. Harris HA. Estrogen receptor-β: recent lessons from in vivo studies. Mol Endocrinol 2007, 21: 1-13.
29. Pensler JM, Silverman BL, Sanghavi J, et al. Estrogen and progesterone receptors in gynecomastia. Plast Reconstr Surg 2000, 106: 1011-3.
30. Niewoehner CB, Schorer AE. Gynaecomastia and breast cancer in men. BMJ 2008, 336: 709-13.