Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 7, 2012, Pages 717-727

  Kannt, Aimo ^a   Sicka, Kerstin ^a   Kroll, Katja ^a   Kadereit, Dieter ^a   Gögelein, Heinz ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

ADP ribosyl cyclase; Antiarrhythmic agents; Ca channel; Cyclic ADP ribose; Ventricular arrhythmias

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE INHIBITOR; ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL; CYCLIC ADENOSINE DIPHOSPHORIBOSE; DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE HYPOXANTHINE DINUCLEOTIDE; RYANODINE RECEPTOR; SAN 2589; SAN 4825; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARRHYTHMOGENESIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; EXPERIMENTAL MODEL; GUINEA PIG; HEART ARREST; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART PAPILLARY MUSCLE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HIGH THROUGHPUT SCREENING; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; SARCOPLASMIC RETICULUM; SWINE;

ADP-RIBOSYL CYCLASE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; ENZYME INHIBITORS; GUINEA PIGS; HEART; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HETEROCYCLIC COMPOUNDS, 3-RING; MYOCARDIUM; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; RATS; SARCOPLASMIC RETICULUM; SWINE; VENTRICULAR FIBRILLATION;

EID: 84862845682     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0750-2     Document Type: Article

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