Metabolite investigation in both anterior and posterior cingulate gyri in Alzheimer's disease spectrum using 3-Tesla MR spectroscopy

Dementia and Geriatric Cognitive Disorders

Volumn 33, Issue 2-3, 2012, Pages 149-155

  Lim, Tae Sung ^a   Hong, Yoon Hee ^a   Lee, Hyun Young ^b,c   Choi, Jun Young ^a   Kim, Ho Sung ^d   Moon, So Young ^a  

^a Ajou University School of Medicine   (South Korea)

^b Ajou University Medical Center   (South Korea)

^c Yonsei University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

Alzheimer's disease; Anterior and posterior cingulate gyri; Magnetic resonance spectroscopy; Mild cognitive impairment

Indexed keywords

CREATININE; INOSITOL; N ACETYLASPARTIC ACID;

AGED; ALZHEIMER DISEASE; ANTERIOR CINGULATE; ARTICLE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEUROPSYCHIATRIC INVENTORY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSTERIOR CINGULATE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASPARTIC ACID; COGNITION DISORDERS; CREATINE; DISEASE PROGRESSION; FEMALE; GYRUS CINGULI; HUMANS; INOSITOL; INTELLIGENCE TESTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; STATISTICS AS TOPIC;

EID: 84862844269     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000338177     Document Type: Article

References (29)

1. Kantarci K: 1H magnetic resonance spectroscopy in dementia. Br J Radiol 2007; 80(spec No 2):S146-S152.
2. Schuff N, Amend D, Ezekiel F, Steinman SK, Tanabe J, Norman D, Jagust W, Kramer JH, Mastrianni JA, Fein G, Weiner MW: Changes of hippocampal n-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology 1997;49:1513-1521.
3. Chen SQ, Wang PJ, Ten GJ, Zhan W, Li MH, Zang FC: Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice. Dement Geriatr Cogn Disord 2009;28:558-566.
4. Bitsch A, Bruhn H, Vougioukas V, Stringaris A, Lassman H, Frahm J, Brück W: Inflammatory CNS demyelination: Histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 1999;20:1619-1627.
5. Kantarci K, Jack CR Jr, Xu YC, Campeau NG, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Kokmen E, Tangalos EG, Petersen RC: Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS study. Neurology 2000;55:210-217.
6. Vogt BA, Vogt L, Laureys S: Cytology and functionally correlated circuits of human posterior cingulate areas. Neuroimage 2006; 29:452-466.
7. Fransson P, Marrelec G: The precuneus/ posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis. Neuroimage 2008;42:1178-1184.
8. Rami L, Gómez-Ansón B, Bosch B, Sánchez-Valle R, Monte GC, Villar A, Molinuevo JL: Cortical brain metabolism as measured by proton spectroscopy is related to memory performance in patients with amnestic mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord 2007;24: 274-279.
9. Shinno H, Inagaki T, Miyaoka T, Okazaki S, Kawamukai T, Utani E, Inami Y, Horiguchi J: A decrease in n-acetylaspartate and an increase in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease. J Neurol Sci 2007;260:132-138.
10. Mihara M, Hattori N, Abe K, Sakoda S, Sawada T: Magnetic resonance spectroscopic study of Alzheimer's disease and frontotemporal dementia/Pick complex. Neuroreport 2006;17:413-416.
11. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
12. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol 1999;56:303-308.
13. Ahn HJ, Chin J, Park A, Lee BH, Suh MK, Seo SW, Na DL: Seoul Neuropsychological Screening Battery -dementia version (SNSB-D): A useful tool for assessing and monitoring cognitive impairments in dementia patients. J Korean Med Sci 2010;25: 1071-1076.
14. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J: The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308-2314.
15. Kang SJ, Choi SH, Lee BH, Jeong Y, Hahm DS, Han IW, Cummings JL, Na DL: Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI). J Geriatr Psychiatry Neurol 2004;17:32-35.
16. Kim H, Na DL: Normative data on the Korean version of the Boston Naming Test. J Clin Exp Neuropsychol 1999;21:127-133.
17. Braak H, Braak E: Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997;18:351-357.
18. Vogt BA, Van Hoesen GW, Vogt LJ: Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease. Acta Neuropathol 1990;80:581-589.
19. Jones BF, Barnes J, Uylings HB, Fox NC, Frost C, Witter MP, Scheltens P: Differential regional atrophy of the cingulate gyrus in Alzheimer disease: A volumetric MRI study. Cereb Cortex 2006;16:1701-1708.
20. Kantarci K, Knopman DS, Dickson DW, Parisi JE, Whitwell JL, Weigand SD, Josephs KA, Boeve BF, Petersen RC, Jack CR Jr: Alzheimer disease: Postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements. Radiology 2008;248:210-220.
21. Azevedo D, Tatsch M, Hototian SR, Bazzarella MC, Castro CC, Bottino CM: Proton spectroscopy in Alzheimer's disease and cognitive impairment no dementia: A community-based study. Dement Geriatr Cogn Disord 2008;25:491-500.
22. García Santos JM, Gavrila D, Antúnez C, Tormo MJ, Salmerón D, Carles R, Jiménez Veiga J, Parrilla G, Torres del Río S, Fortuna L, Navarro C: Magnetic resonance spectroscopy performance for detection of dementia, Alzheimer's disease and mild cognitive impairment in a community-based survey. Dement Geriatr Cogn Disord 2008;26: 15-25.
23. Metastasio A, Rinaldi P, Tarducci R, Mariani E, Feliziani FT, Cherubini A, Pelliccioli GP, Gobbi G, Senin U, Mecocci P: Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy. Neurobiol Aging 2006;27:926-932.
24. Siger M, Schuff N, Zhu X, Miller BL, Weiner MW: Regional myo-inositol concentration in mild cognitive impairment Using 1H magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord 2009;23:57-62.
25. Visser PJ, Verhey F, Knol DL, Scheltens P, Wahlund LO, Freund-Levi Y, Tsolaki M, Minthon L, Wallin AK, Hampel H, Bürger K, Pirttila T, Soininen H, Rikkert MO, Verbeek MM, Spiru L, Blennow K: Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: A prospective cohort study. Lancet Neurol 2009;8:619-627.
26. Reyngoudt H, Claeys T, Vlerick L, Verleden S, Acou M, Deblaere K, De Deene Y, Audenaert K, Goethals I, Achten E: Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: A (1)H-MRS study. Eur J Radiol 2012;81:e223-e231.
27. Pilatus U, Lais C, Rochmont Adu M, Kratzsch T, Frölich L, Maurer K, Zanella FE, Lanfermann H, Pantel J: Conversion to dementia in mild cognitive impairment is associated with decline of n-actylaspartate and creatine as revealed by magnetic resonance spectroscopy. Psychiatry Res 2009;173: 1-7.
28. Watanabe T, Shiino A, Akiguchi I: Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease. Dement Geriatr Cogn Disord 2008;26:89-100.
29. Watanabe T, Shiino A, Akiguchi I: Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging. Dement Geriatr Cogn Disord 2010;30:71-77.