Pelvic inflammatory disease: Current concepts of diagnosis and management

Current Infectious Disease Reports

Volumn 14, Issue 2, 2012, Pages 194-203

  Sweet, Richard L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diagnosis; Pelvic inflammatory disease; Salpingitis; Treatment

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; AZITHROMYCIN; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFTIZOXIME; CEFTRIAXONE; CLINDAMYCIN; DOXYCYCLINE; GENTAMICIN; METRONIDAZOLE; PROBENECID; SULTAMICILLIN;

ABDOMINAL INFECTION; ACUTE DISEASE; ANTIMICROBIAL THERAPY; ARTICLE; ASYMPTOMATIC INFECTION; BED REST; CAUSAL ATTRIBUTION; CHLAMYDIA TRACHOMATIS; CLINICAL FEATURE; COMBINATION CHEMOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; DOPPLER ECHOGRAPHY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DOSE INCREASE; DRUG EFFICACY; EARLY DIAGNOSIS; ECTOPIC PREGNANCY; ENDOMETRIUM BIOPSY; FEMALE INFERTILITY; HEALTH CARE COST; HOSPITALIZATION; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; LABORATORY TEST; LOADING DRUG DOSE; MONOTHERAPY; MYCOPLASMA GENITALIUM; NEISSERIA GONORRHOEAE; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PELVIC INFLAMMATORY DISEASE; PELVIS PAIN SYNDROME; PUBLIC HEALTH PROBLEM; SEXUALITY; SINGLE DRUG DOSE; TREATMENT DURATION; TREATMENT PLANNING; TUBOOVARIAN ABSCESS; VAGINA FLORA; VAGINITIS;

EID: 84862839715     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-012-0243-y     Document Type: Article

References (76)

1. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR 2010;59(No. RR-12):63-67. Major resource for the treatment of acute PID
2. Ross J, Judlin P, Niles L. European guideline for the management of pelvic inflammatory disease. Int J STD AIDS. 2007;18:662-6. (Pubitemid 351738895)
3. Sweet RL. Microbiology. In: Sweet RL, Wiesenfeld HC, editors. Pelvic inflammatory disease. London: Taylor & Francis; 2006. p. 19-48.
4. Haggerty CL, Ness RB: Diagnosis and treatment of pelvic inflammatory disease. Women's Health 2008;4:383-97. Excellent review of the diagnosis and treatment of PID
5. Smith KJ, Ness RB, Wiesenfeld HC, Roberts MS. Cost-effectiveness of alternative outpatient pelvic inflammatory disease treatment strategies. Sex Transm Dis. 2007;34:960-6. (Pubitemid 350158845)
6. Sutton MY, Sternberg M, Zaidi A, et al. Trends in pelvic inflammatory disease hospital discharges and ambulatory visits, United States; 1985-2001. Sex Transm Dis. 2005;32:778-84. (Pubitemid 41752566)
7. Rein DB, Kassler WJ, Irwin KL, Rabiee L. Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing but still substantial. Obstet Gynecol. 2000;95:397-402. (Pubitemid 30100506)
8. Botte J, Peipert JF. Epidemiology. In: Sweet RL, Wiesenfeld HC, ditors. Pelvic inflammatory disease. London: Taylor & Francis; 2006. p. 1-18.
9. Haggerty CL, Ress RB. Epidemiology, pathogenesis and treatment of pelvic inflammatory disease. Expert Rev Anti Infect Ther. 2006;4:235-47.
10. Westrom L: Effect of acute pelvic inflammatory disease on fertility. Am J Obstet Gynecol 1975;121:707-13. Classic study on impact of PID on reproductive health of women
11. Westrom L, Josef R, Reynolds G, et al. Pelvic inflammatory disease and fertility. A cohort study of 1844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex Transm Dis. 1992;19:185-92.
12. Haggerty CL, Shultz R, Ness RB. Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease. Obstet Gynecol. 2003;102:934-9. (Pubitemid 37412280)
13. Thurman AR, Soper DE. Sequelae. In: Sweet RL, Wiesenfeld HC, editors. Pelvic inflammatory disease. London: Taylor & Francis; 2006. p. 69-84.
14. Wiesenfeld HC, Hillier SL, Krohn MA, et al.: Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet Gynecol 2002;100:265-63. Study clearly demonstrates the association of subclinical PID with lower genital tract infection with N. gonorrhoeae, C. trachomatis and BV
15. Wolner-Hanssen P, Kiviat NB, Holmes KK. Atypical pelvic inflammatory disease: subacute, chronic or subclinical upper genital tract infection in women. In: Holmes KK, Mardh P-A, Sparling PF, et al., editors. Sexually transmitted diseases. New York: McGraw-Hill; 1990. p. 615-20.
16. Westrom L, Eschenbach DA. Pelvic inflammatory disease. In: Holmes KK, Sparling PF, Mardh P-A, Lemon J, Stamm W, Piot P, Wasserheit JN, editors. Sexually transmitted diseases. New York: McGraw-Hill; 1999. p. 783-809.
17. Walker CK, Wiesenfeld HC. Antibiotic therapy for acute pelvic inflammatory disease: the 2006 centers for disease control and prevention sexually transmitted diseases treatment guidelines. Clin Infect Dis. 2007;44:S111-22. (Pubitemid 46452044)
18. Haggerty CL, Ness RB. Newest approaches to treatment of pelvic nflammatory disease: a review of recent randomized trials. Clin Infect Dis. 2007;44:953-60. (Pubitemid 46452060)
19. Sweet RL, Gibbs RS: Pelvic inflammatory disease. In Sweet RL, Gibbs RS Infectious Diseases of the Female Genital Tract. Lippincott, Williams & Wilkins, Philadelphia, 2009, pp 220-44. Very comprehensive review of the epidemiology, pathogenesis, etiology, diagnosis, and treatment of acute PID
20. Kiviat NB, Wolner-Hanssen P, Eschenbach DA, et al. Endometrial histopathology in patients with culture-proven upper genital tract infection and laparoscopically diagnosed acute salpingitis. Am J Surg Pathol. 1990;14:167-75. (Pubitemid 20039012)
21. Wiesenfeld HC, Sweet RL, Ness RB, et al. Comparison of acute and subclinical pelvic inflammatory disease. Sex Transm Dis. 2005;32:400-5. (Pubitemid 40875375)
22. Jacobsen L, Westrom L: Objectivized diagnosis of acute pelvic inflammatory disease. Am J Obstet Gynecol 1969;105:1088. Classic study on use of laparoscopy to confirm diagnosis of acute salpingitis
23. Hager WD, Eschenbach DA, Spence MR, Sweet RL. Criteria for diagnosis and grading of salpingitis. Obstet Gynecol. 1983;61:113-4. (Pubitemid 13212386)
24. Kahn JG, Walker CK, Washington AE, et al. Diagnosing pelvic inflammatory disease: a comprehensive analysis and considerations for developing a new model. JAMA. 1991;266:2594-604.
25. Soper DE. Surgical considerations in the diagnosis and treatment of pelvic inflammatory disease. Surg Clin North Am. 1991;71:947-62.
26. Hemila M, Henriksson L, Ylkorkala O. Serum CRP in the diagnosis of pelvic inflammatory disease. Arch Gynecol Obstet. 1987;241:177-82. (Pubitemid 18042767)
27. Duk JM, Kauer FM, Fleuren GJ, deBruign HW. Serum CA 125 levels in patients with provisional diagnosis of pelvic inflammatory disease. Clinical and theoretical implications. Acta Obstet Gynecol Scand. 1989;68:637-41. (Pubitemid 20145524)
28. Mozas J, Castilla JA, Jimena P, et al. Serum CA 125 in the diagnosis of acute pelvic inflammatory disease. Int J Gynaecol Obstet. 1994;44:53-7.
29. Paavonen J, Mettinen A, Heinonen PK, et al. Serum CA-125 in acute pelvic inflammatory disease. Br J Obstet Gynaecol. 1989;96:574-9. (Pubitemid 19146814)
30. Moore E, Soper DE. Clinical utility of CA 125 levels in predicting laparoscopically confirmed salpingitis in patients with clinically diagnosed pelvic inflammatory disease. Infect Dis Obstet Gynecol. 1988;6:182-5.
31. Paavonen J, Critchlow CW, DeRoven T, et al. Biology of cervical inflammation. Am J Obstet Gynecol. 1986;154:556-64.
32. Peipert JF, Boardman L, Hogan JW, et al. Laboratory evaluation of acute upper genital tract infection. Obstet Gynecol. 1996;87:730-6. (Pubitemid 26127092)
33. Jaiyeoba O, Soper DE: A practical approach to the diagnosis of pelvic inflammatory disease. Infect Dis Ob Gyn (In Press).
34. Timor-Tritsch E, Rotten S. Transvaginal ultrasonographic study of the fallopian tube. Obstet Gynecol. 1987;70:424-8.
35. Tukeva TA, Aronen HJ, Karjalainen PT, et al. MR imaging in pelvic inflammatory disease: comparison with laparoscopy and US. Radiology. 1999;210:209-16. (Pubitemid 29004306)
36. Eschenbach DA, Buchanan T, Pollock HM, et al. Polymicrobial etiology of acute pelvic inflammatory disease. N Engl J Med. 1975;293:166-71.
37. Sweet RL, Draper DL, Schachter J, et al. Microbiology and pathogenesis of acute salpingitis as determined by laparoscopy: what is the appropriate site to sample? Am J Obstet Gynecol. 1980;138:985-9. (Pubitemid 11198977)
38. Sweet RL. Sexually transmitted diseases. Pelvic inflammatory disease and infertility in women. Infect Dis Clin North Am. 1987;1:199-215.
39. Sweet RL, Schachter J, Robbie MO. Failure of beta-lactam antibiotics to eradicate Chlamydia trachomatis in the endometrium despite apparent clinical cure of acute salpingitis. JAMA. 1983;250:2641-5. (Pubitemid 14225133)
40. Wasserheit JN, Bell TA, Kiviat NB, et al. Microbial causes of proven pelvic inflammatory disease and efficacy of clindamycin and tobramycin. Ann Int Med. 1986;104:187-93. (Pubitemid 16134701)
41. Heinonen PK, Teisala K, Punnonen R, et al. Anatomic sites of upper genital tract infection. Obstet Gynecol. 1985;66:384-90. (Pubitemid 15016579)
42. Paavonen J, Teisala K, Heinonen PK, et al. Microbiological and histopathological findings in acute pelvic inflammatory disease. Brit J Obstet Gynaecol. 1987;94:454-60. (Pubitemid 17068096)
43. Brunham RC, Binns B, Guijon F, et al. Etiology and outcome of acute pelvic inflammatory disease. J Infect Dis. 1988;158:510-7.
44. Soper DE, Brockwell NJ, Dalton HP, Johnson D. Observations concerning the microbial etiology of acute salpingitis. Am J Obstet Gynecol. 1994;170:1008-17. (Pubitemid 24157911)
45. Hillier SL, Kiviat NB, Hawes SE, et al. Role of bacterial vaginosisassociated microorganisms in endometritis. Am J Obstet Gynecol. 1996;175:435-41. (Pubitemid 26391004)
46. Haggerty CL, Hillier SL, Bass DC, et al. Bacterial vaginosis and anaerobic bacteria are associated with endometritis. CID. 2004;39:990-5. (Pubitemid 39313455)
47. Cohen CR, Manhart LE, Bukusi EA, et al. Association between Mycoplasma genitalium and acute endometritis. Lancet. 2002;359:765-6. (Pubitemid 34215080)
48. Simms I, Eastick K, Mallinson H, et al. Association between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. J Clin Pathol. 2003;56:616-8. (Pubitemid 36976362)
49. Cohen CR, Mugo NR, Astete SG, et al. Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis. Sex Transm Infect. 2005;81:463-6. (Pubitemid 41811326)
50. Haggerty CL, Totten PA, Astete SG, et al. Failure of cefoxitin and doxycycline to eradicate endometrial Mycoplasma genitalium and the consequence for clinical cure of pelvic inflammatory disease. Sex Transm Infect. 2008;84:338-42.
51. Short VL, Totten PA, Ness RB, et al.: Clinical presentation of Mycoplasma genitalium infection versus Neisseria gonorrhoeae infection among women with pelvic inflammatory disease. Clin Infect Dis 2009;48:41-7. Study identifies that M. genitalium may play an important putative role in the etiology of acute PID
52. Ness RB, Soper DE, Holley RL, et al. Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) randomized trial. Am J Obstet Gynecol. 2002;186:929-37.
53. Ness RB, Hillier SL, Kip KE, et al. Bacterial vaginosis and risk of pelvic inflammatory disease. Obstet Gynecol. 2004;104:761-9. (Pubitemid 40458806)
54. Korn AP, Bolan G, Padian N, et al. Plasma cell endometritis in women with symptomatic bacterial vaginosis. Obstet Gynecol. 1995;85:387-90.
55. Peipert JF, Montagno AB, Cooper AS, Sung CJ. Bacterial vaginosis as a risk factor for upper genital tract infection. Am J Obstet Gynecol. 1997;177:1184-7. (Pubitemid 27525380)
56. Sweet RL. Role of bacterial vaginosis in pelvic inflammatory disease. Clin Infect Dis. 1995;20 Suppl 2:271-5.
57. Ness RB, Kip KE, Hillier SL, et al. A cluster analysis of bacterial vaginosis-associated microflora and pelvic inflammatory disease. Am J Epidemiol. 2005;162:585-90. (Pubitemid 41253257)
58. Hebb JK, Cohen CR, Astete SG, et al. Detection of novel organisms associated with salpingitis, by use of 16S rDNA polymerase chain reaction. J Infect Dis. 2004;190:2109-20. (Pubitemid 39636358)
59. Hillis SD, Joesoef R, Marchbanks PA, et al. Delayed care of pelvic inflammatory disease as a risk factor for impaired fertility. Am J Obstet Gynecol. 1993;168:1503-9. (Pubitemid 23153297)
60. Smith J, Ness RB, Wiesenfeld HC, et al. Cost-effectiveness of alternate outpatient pelvic inflammatory disease treatment strategies. Sex Transm Dis. 2007;34:960-6. (Pubitemid 350158845)
61. Amsden GW. Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic pulmonary conditions. J Antimicro Chemother. 2005;55:10-21. (Pubitemid 40192609)
62. Patton DL, Sweeney YT, Stamm WE. Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. JID. 2005;192:129-35. (Pubitemid 40863865)
63. Bevan CD, Ridgway GL, Rothermel CD. Efficacy and safety of azithromycin as monotherapy or combined with metronidazole compared with two standard multidrug regimens for the treatment of acute pelvic inflammatory disease. J Int Med Res. 2003;31:45-54. (Pubitemid 36335875)
64. Ness RB, Trautmann G, Richter HE, et al. Effectiveness of treatment strategies of some women with pelvic inflammatory disease: a randomized trial. Obstet Gynecol. 2005;106:573-80. (Pubitemid 41208792)
65. McGregor JA, Crombleholme WR, Newton E, et al. Randomized comparison of ampicillin-sulbactam to cefoxitin and doxycycline or clindamycin and gentamicin in the treatment of pelvic inflammatory disease or endometritis. Ostet Gynecol. 1994;83:998-1004. (Pubitemid 24165397)
66. Savaris RF, Teixeira LM, Torres G, et al. Comparing ceftriaxone plus azithromycin or doxycyline for pelvic inflammatory disease, a randomized controlled trial. Obstet Gynecol. 2007;110:53-60. (Pubitemid 47015700)
67. Yip L, Sweeny PJ, Bock BF. Acute suppurative salpingitis with concomitant intrauterine pregnancy. Am J Emerg Med. 1993;11:476-9. (Pubitemid 23263582)
68. Blanchard AC, Pastorek 2nd JG, Weeks T. Pelvic inflammatory disease during pregnancy. South Med J. 1987;80:1363-5. (Pubitemid 18003247)
69. Hemsell DL, Ledger WJ, Martens M, et al. Concerns regarding the centers for disease control's published guidelines for pelvic inflammatory disease. Clin Infect Dis. 2001;32:103-7. (Pubitemid 32150954)
70. Korn AP, Landers DV, Green JR, Sweet RL. Pelvic inflammatory disease in human immunodeficiency virus-infected women. Obstet Gynecol. 1993;82:765-8. (Pubitemid 23312184)
71. Irwin KL, Moorman AC, O'Sullivan MJ, et al. Influence of human immunodeficiency virus infection on pelvic inflammatory disease. Obstet Gynecol. 2000;95:525-34. (Pubitemid 30139571)
72. Cohen CR, Sinei R, Reilly M, et al. Effect of human immunodeficiency virus type 1 infection upon acute salpingitis: a laparoscopic study. J Infect Dis. 1998;178:1352-8.
73. Bakusi EA, Cohen CR, Stevens CE, et al. Effects of human immunodeficiency virus 1 infection on microbial origins of pelvic inflammatory disease and on the efficacy of ambulatory oral therapy. Am J Obstet Gynecol. 1999;181:1374-81. (Pubitemid 30021879)
74. Mugo NR, Kiehlbauch JA, Nguti R, et al. Effect of human immunodeficiency virus-1 infection on treatment outcomes of acute salpingitis. Obstet Gynecol. 2006;107:807-12.
75. Soderberg G, Lindgren S. Influence of an intrauterine device on the course of acute salpingitis. Contraception. 1981;24:137-43. (Pubitemid 11019194)
76. Altunyurt S, Demir N, Posaci C. A randomized trial of coil removal prior to treatment of pelvic inflammatory disease. Eur J Obstet Gynecol Reprod Biol. 2003;107:81-4. (Pubitemid 36194762)