Reduced expression of microtubule-associated protein 1 light chain 3 in hypertrophic scars

Archives of Dermatological Research

Volumn 304, Issue 3, 2012, Pages 209-215

  Shi, Ji Hong ^a   Hu, Da Hai ^a   Zhang, Zhan Feng ^a   Bai, Xiao Zhi ^a   Wang, Hong Tao ^a   Zhu, Xiong Xiang ^a   Su, Ying Jun ^a   Tang, Chao Wu ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Autophagy related gene; Beclin 1; Hypertrophic scar; Microtubule associated protein 1 light chain 3 (LC3)

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; COLLAGEN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS CELL; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTROPHIC SCAR; IMMUNOHISTOCHEMISTRY; MOLECULAR WEIGHT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADOLESCENT; ADULT; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CHILD; CICATRIX, HYPERTROPHIC; HUMANS; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; YOUNG ADULT;

EID: 84862835956     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-012-1204-x     Document Type: Article

References (23)

1. Asanuma K, Tanida I, Shirato I, Ueno T, Takahara H, Nishitani T, Kominami E, Tomino Y (2003) MAP-LC3 a promising autophagosomal marker, is processed during the diVerentiation and recovery of podocytes from PAN nephrosis. FASEB J 17:1165-1167
2. Jin S, White E (2008) Tumor suppression by autophagy through the management of metabolic stress. Autophagy 4:563-566
3. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19:5720-5728
4. Kroemer G, Jaattela M (2005) Lysosome and autophagy in cell death control. Nat Rev Cancer 5:886-897
5. Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27-42
6. Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, Akira S, Noda T, Yoshimori T (2009) Two Beclin1-binding proteins, Atg14L and rubicon, reciprocally regulate autophagy at diVerent stages. Nat Cell Biol 11:385-396
7. Meijer AJ, Dubbelhuis PF (2004) Amino acid signaling and the integration of metabolism. Biochem Biophys Res Commun 313:397-403
8. Mizushima N, Yoshimori T, Ohsumi Y (2003) Role of the Apg12 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 35:553-561
9. Niessen FB, Spauwen PH, Schalkwijk J, Kon M (1999) On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 104:1435-1458
10. Ong CT, Khoo YT, Mukhopadhyay A, Do DV, Lim IJ, Aalami O, Phan TT (2007) mTOR as a potential therapeutic target for treatment of keloids and excessive scars. Exp Dermatol 16:394-404
11. Orvadahl A, Levine B (2009) Eating the enemy within: autophagy in infectious diseases. Cell Death DiVer 16:57-69
12. Riddle DL, Gorski SM (2003) Shaping and stretching life by autophagy. Dev Cell 5:364-365
13. Shibata M, Yoshimura K, Furuya N, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y (2009) The MAP1-LC3 conjugation system is involved in lipid droplet formatiom. Biochem Biophys Res Commun 382:419-423
14. Shintani T, Kllonsky DJ (2004) Autophagy in heath and disease: a double-edged sword. Science 306:990-995
15. Tanida I, Minematsu-Ikequchi N, Ueno T, Kominami E (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1:84-91
16. Tanida I, Ueno T, Kominami E (2004) LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 36:2503-2518
17. Todde V, Veenhuis M, van der Klei IJ (2009) Autophagy: principles and signiWcance in health and disease. Biochim Biophy Acta 1792:3-13
18. Tanida I, Nishitani T, Nemoto T, Ueno T, Kominami E (2002) Mammalian Apg12p, but not the Apg12p-Apg5p conjugate, facilitates LC3 processing. Biochem Biophys Res Commun 296:1164-1170
19. van der Veer WM, Bloemen MC, Ulrich MM, Molema G, van Zuijen PP, Middelkoop E, Niessen FB (2009) Potential cellular and molecular causes of hypertrophic scar. Burns 35:15-29
20. Winslow AR, Rubinsztein DC (2008) Autophagy in neurodegeneration and development. Biochim Biophys Acta 1782:723-729
21. Wolfram D, Tzankov A, Pülzl P, Piza-Katzer H (2009) Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 35:171-181
22. Yen WL, Klionsky DJ (2008) How to live long and prosper: autophagy, mitochondria, and aging. Physiology 23:248-262
23. Yoshimori T (2004) Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Commun 313:453-458