Proteomic profiling of inflammatory signaling molecules in the tears of patients on chronic glaucoma medication

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 10, 2011, Pages 7385-7391

  Wong, Tina T ^a,b,c   Zhou, Lei ^a,b   Li, Jing ^a,b   Tong, Louis ^a,c,d   Zhao, Shao Zhen ^e   Li, Xiao Rong ^e   Yu, Shang Juan ^a   Koh, Siew Kwan ^a   Beuerman, Roger W ^a,b,d  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c SINGAPORE NATIONAL EYE CENTRE   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGLAUCOMA AGENT; CALGRANULIN A; CALGRANULIN B; MAMMAGLOBIN B; PROLINE RICH PROTEIN; TEAR PROTEIN; ANTIHYPERTENSIVE AGENT; EYE PROTEIN; PEPTIDE FRAGMENT; TEAR PROTEINS;

AGED; ARTICLE; CLINICAL ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; FEMALE; GLAUCOMA; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIRMER TEST; WESTERN BLOTTING; COMPARATIVE STUDY; DRY EYE; EXPRESSED SEQUENCE TAG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LACRIMAL FLUID; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROTEIN MICROARRAY; PROTEOMICS; TANDEM MASS SPECTROMETRY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AGED; ANTIHYPERTENSIVE AGENTS; BLOTTING, WESTERN; DRY EYE SYNDROMES; EXPRESSED SEQUENCE TAGS; EYE PROTEINS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLAUCOMA; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTEIN ARRAY ANALYSIS; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TEARS;

EID: 84862833065     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6532     Document Type: Article

References (40)

1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262-267.
2. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol. 2000; 130(4):429-440.
3. Jaenen N, Baudouin C, Pouliquen P, Manni G, Figueiredo A, Zeyen T. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol. 2007;17(3):341-349.
4. Nuzzi R, Finazzo C, Cerruti A. Adverse effects of topical antiglaucomatous medications on the conjunctiva and the lachrymal (Brit. Engl) response. Int Ophthalmol. 1998;22(1):31-35.
5. Kuppens EV, de Jong CA, Stolwijk TR, de Keizer RJ, van Best JA. Effect of timolol with and without preservative on the basal tear turnover in glaucoma. Br J Ophthalmol. 1995;79(4):339-342.
6. Wilson WS, Duncan AJ, Jay JL. Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man. Br J Ophthalmol. 1975;59(11):667-669.
7. Herreras JM, Pastor JC, Calonge M, Asensio VM. Ocular surface alteration after long-term treatment with an antiglaucomatous drug. Ophthalmology. 1992;99(7):1082-1088.
8. Baudouin C, Liang H, Hamard P, et al. The ocular surface of glaucoma patients treated over the long term expresses inflammatory markers related to both T-helper 1 and T-helper 2 pathways. Ophthalmology. 2008;115(1):109-115.
9. Baudouin C, Hamard P, Liang H, Creuzot-Garcher C, Bensoussan L, Brignole F. Conjunctival epithelial cell expression of interleukins and inflammatory markers in glaucoma patients treated over the long term. Ophthalmology. 2004;111(12):2186-2192.
10. Chong RS, Jiang YZ, Boey PY, et al. Tear cytokine profile in medicated glaucoma patients effect of monocyte chemoattractant protein 1 on early posttrabeculectomy outcome. Ophthalmology. 2010;117(12):2353-2358.
11. Zhou L, Beuerman RW, Chan CM, et al. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res. 2009;8(11):4889-4905.
12. Nichols JJ, Green-Church KB. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. Cornea. 2009;28(10): 1109-1117.
13. Zhou L, Huang LQ, Beuerman RW, et al. Proteomic analysis of human tears: defensin expression after ocular surface surgery. J Proteome Res. 2004;3(3):410-416.
14. Baudouin C. Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma. Acta Ophthalmol. 2008; 86(7):716-726.
15. Pisella PJ, Pouliquen P, Baudouin C. Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Br J Ophthalmol. 2002;86(4):418-423.
16. Grus FH, Podust VN, Bruns K, et al. SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye. Invest Ophthalmol Vis Sci. 2005;46(3):863-876.
17. Zhou L, Beuerman RW, Huang L, et al. Proteomic analysis of rabbit tear fluid: defensin levels after an experimental corneal wound are correlated to wound closure. Proteomics. 2007;7(17):3194-3206.
18. Zhou L, Beuerman RW, Foo Y, Liu S, Ang LP, Tan DT. Characterisation of human tear proteins using high-resolution mass spectrometry. Ann Acad Med Singapore. 2006;35(6):400-407.
19. Zhou L, Beuerman RW, Chew AP, et al. Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture andiTRAQ. J Proteome Res. 2009;8(4): 1992-2003.
20. Zhou L, Beuerman RW, Barathi A, Tan D. Analysis of rabbit tear proteins by high-pressure liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(5):401-412.
21. Zhou L, Beuerman RW, Ang LP, et al. Elevation of human alphadefensins and S100 calcium-binding proteins A8 and A9 in tear fluid of patients with pterygium. Invest Ophthalmol Vis Sci. 2009; 50(5):2077-2086.
22. Tomosugi N, Kitagawa K, Takahashi N, Sugai S, Ishikawa I. Diagnostic potential of tear proteomic patterns in Sjogren's syndrome. J Proteome Res. 2005;4(3):820-825.
23. Sack RA, Conradi L, Krumholz D, Beaton A, Sathe S, Morris C. Membrane array characterization of 80 chemokines, cytokines, and growth factors in open-and closed-eye tears: angiogenin and other defense system constituents. Invest Ophthalmol Vis Sci. 2005;46(4):1228-1238.
24. Koo BS, Lee DY, Ha HS, Kim JC, Kim CW. Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. J Proteome Res. 2005;4(3):719-724.
25. Jacob JT, Ham B. Compositional profiling and biomarker identification of the tear film. Ocul Surf. 2008;6(4):175-185.
26. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop. Ocul Surf.2007;5(2):93-107.
27. Jie Y, Xu L, Wu YY, Jonas JB. Prevalence of dry eye among adult Chinese in the Beijing Eye Study. Eye. 2009;23(3):688-693.
28. Uchino M, Dogru M, Yagi Y, et al. The features of dry eye disease in a Japanese elderly population. Optom Vis Sci. 2006;83(11):797-802.
29. Morrison DK. The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol. 2009;19(1):16-23.
30. Obsilova V, Silhan J, Boura E, Teisinger J, Obsil T. 14-3-3 proteins: a family of versatile molecular regulators. Physiol Res. 2008; 57(suppl 3):S11-S21.
31. Shankardas J, Senchyna M, Dimitrijevich SD. Presence and distribution of 14-3-3 proteins in human ocular surface tissues. Mol Vis. 2008;14:2604-2615.
32. Roth J, Vogl T, Sorg C, Sunderkotter C. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol. 2003;24(4):155-158.
33. Stoeckelhuber M, Messmer EM, Schmidt C, Xiao F, Schubert C, Klug J. Immunohistochemical analysis of secretoglobin SCGB 2A1 expression in human ocular glands and tissues. Histochem Cell Biol. 2006;126(1):103-109.
34. Muller-Schottle F, Classen-Linke I, Beier-Hellwig K, Sterzik K, Beier HM. Uteroglobin expression and release in the human endometrium. Ann N Y Acad Sci. 2000;923:332-335.
35. Tassi RA, Calza S, Ravaggi A, et al. Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence. BMC Cancer. 2009;9:253.
36. Redl B. Human tear lipocalin. Biochim Biophys Acta. 2000; 1482(1-2):241-248.
37. Fung KY, Morris C, Sathe S, Sack R, Duncan MW. Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid. Proteomics. 2004;4(12):3953-3959.
38. Moreno EC, Kresak M, Hay DI. Adsorption thermodynamics of acidic prolinerich human salivary proteins onto calcium apatites. J Biol Chem. 1982;257(6):2981-2989.
39. Ligtenberg AJ, Walgreen-Weterings E, Veerman EC, de Soet JJ, de Graaff J, Amerongen AV. Influence of saliva on aggregation and adherence of Streptococcus gordonii HG 222. Infect Immun. 1992;60(9):3878-3884.
40. Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma. 2008;17(5):350-355.