An efficient enantioselective synthesis of florfenicol based on sharpless asymmetric dihydroxylation

Synthesis

Volumn 44, Issue 5, 2012, Pages 699-704

  Wang, Zhong Hua ^a   Zheng, Chen ^a   Li, Feng ^a   Zhao, Lei ^a   Chen, Fen Er ^a   He, Qiu Qin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

asymmetric synthesis; drugs; halogenation; heterocycles; sulfones

Indexed keywords

ASYMMETRIC DIHYDROXYLATION; ASYMMETRIC SYNTHESIS; CHLORINATED BYPRODUCTS; DRUGS; ENANTIOSELECTIVE SYNTHESIS; FLORFENICOL; HETEROCYCLES; RING OPENING; SULFONES;

ALDEHYDES; HALOGENATION; HYDROXYLATION;

ENANTIOSELECTIVITY;

(4 FLUOROMETHYL) 2 (4 METHOXYPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1,3 OXAZOLE; 4 (METHYLSULFONYL)BENZALDEHYDE; [2 (4 METHOXYPHENYL) 5 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1,3 OXAZOLE 4 YL]METHANOL; ETHYL 2 (4 METHOXYPHENYL)5 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1,3 OXAZOLE 4 CARBOXYLIC ACID; ETHYL 2,3 DIHYDROXY 3 [4 (METHYLSULFONYL)PHENYL]PROPIONIC ACID; ETHYL 3 [4 (METHYLSULFONYL)PHENYL]ACRYLATE; ETHYL 3 HYDROXY 2 [(4 METHOXYBENZOYL)AMINO] 3 [4 (METHYLSULFONYL)PHENYL]PROPIONIC ACID; ETHYL 3 HYDROXY 3 [4 (METHYLSULFONYL)PHENYL] 2 [[(4 NITROPHENYL)SULFONYL]OXY]PROPIONIC ACID; FLORFENICOL; FLORFENICOL [1;2,2 DICHLORO N [1 (FLUOROMETHYL) 2 HYDROXY 2 [4 (METHYLSULFONYL)PHENYL]ETHYL]ACETAMIDE]; METHYL 2,3 DIHYDROXY 3 [4 (METHYLSULFONYL)PHENYL]PROPIONIC ACID; METHYL 3 [4 (METHYLSULFONYL)PHENYL]ACRYLATE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DIHYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY;

EID: 84862831127     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1289706     Document Type: Article

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