Lipoxin A4 Inhibits the Development of Endometriosis in Mice: The Role of Anti-Inflammation and Anti-Angiogenesis

American Journal of Reproductive Immunology

Volumn 67, Issue 6, 2012, Pages 491-497

  Xu, Zhangye ^a   Zhao, Feng ^a   Lin, Feng ^a   Chen, Jinxia ^a   Huang, Yingping ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Lipoxin A4; Matrix metalloproteinase; Pro inflammatory factors; Vascular endothelial growth factor

Indexed keywords

GELATINASE A; GELATINASE B; LIPOXIN A; MESSENGER RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENDOMETRIOSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OVARY FUNCTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ZYMOGRAPHY;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOKINES; ENDOMETRIOSIS; FEMALE; LIPOXINS; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; OVARY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862830562     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2011.01101.x     Document Type: Article

References (24)

1. Matalliotakis IM, Goumenou AG, Koumantakis GE, et al.: Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines. Int Immunopharmacol 2003; 3:81-89.
2. Ozkan S, Murk W, Arici A: Endometriosis and infertility: epidemiology and evidence-based treatments. Ann N Y Acad Sci 2008; 1127:92-100.
3. Kalu E, Sumar N, Giannopoulos T, et al.: Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis. J Obstet Gynaecol Res 2007; 33:490-495.
4. Khan KN, Kitajima M, Hiraki K, et al.: Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids. Am J Reprod Immunol 2008; 60:383-404.
5. Khan KN, Kitajima M, Hiraki K, et al.: Toll-like receptors in innate immunity: role of bacterial endotoxin and toll-like receptor 4 in endometrium and endometriosis. Gynecol Obstet Invest 2009; 68:40-52.
6. Yoshino O, Osuga Y, Koga K, et al.: Concentrations of interferon-gamma-induced protein-10 (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosis. Am J Reprod Immunol 2003; 50:60-65.
7. Mott JD, Werb Z: Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol 2004; 16:558-564.
8. Kim HO, Yang KM, Kang IS, et al.: Expression of CD44s, vascular endothelial growth factor, matrix metalloproteinase-2 and Ki-67 in peritoneal, rectovaginal and ovarian endometriosis. J Reprod Med 2007; 52:207-213.
9. Maderna P, Godson C: Lipoxins: resolutionary road. Br J Pharmacol 2009; 158:947-959.
10. Serhan CN, Yacoubian S, Yang R: Anti-inflammatory and proresolving lipid mediators. Annu Rev Pathol 2008; 3:279-312.
11. Fierro IM, Kutok JL, Serhan CN: Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A (4) and lipoxin A (4). J Pharmacol Exp Ther 2002; 300:385-392.
12. Sodin-Semrl S, Taddeo B, Tseng D, Varga J, Fiore S: Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. J Immunol 2000; 164:2660-2666.
13. Motohashi E, Kawauchi H, Endo H, et al.: Regulatory expression of lipoxin A4 receptor in physiologically estrus cycle and pathologically endometriosis. Biomed Pharmacother 2005; 59:330-338.
14. Dabrosin C, Gyorffy S, Margetts P, Ross C, Gauldie J: Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Am J Pathol 2002; 161:909-918.
15. Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F: Reactive oxygen species controls endometriosis progression. Am J Pathol 2009; 175:225-234.
16. Kajihara H, Yamada Y, Kanayama S, et al.: New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal. Gynecol Endocrinol 2010; 27:73-79.
17. Wang F, Li H, Yang Z, Du X, Cui M, Wen Z: Expression of interleukin-10 in patients with adenomyosis. Fertil Steril 2009; 91:1681-1685.
18. Taylor RN, Lebovic DI, Mueller MD: Angiogenic factors in endometriosis. Ann N Y Acad Sci 2002; 955:89-100; discussion 118, 396-406.
19. Cohen M, Meisser A, Bischof P: Metalloproteinases and human placental invasiveness. Placenta 2006; 27:783-793.
20. Opdenakker G, Van den Steen PE, Dubois B, et al.: Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 2001; 69:851-859.
21. Mulayim N, Savlu A, Guzeloglu-Kayisli O, Kayisli UA, Arici A: Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8. Fertil Steril 2004; 81(Suppl. 1):904-911.
22. Breier G, Damert A, Plate KH, Risau W: Angiogenesis in embryos and ischemic diseases. Thromb Haemost 1997; 78:678-683.
23. Fasciani A, D'Ambrogio G, Bocci G, Monti M, Genazzani AR, Artini PG: High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata. Mol Hum Reprod 2000; 6:50-54.
24. Takehara M, Ueda M, Yamashita Y, Terai Y, Hung YC, Ueki M: Vascular endothelial growth factor A and C gene expression in endometriosis. Hum Pathol 2004; 35:1369-1375.