Normal-phase liquid chromatography coupled with electrospray ionization mass spectrometry for chiral separation and quantification of clevudine and its enantiomer in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 885-886, Issue , 2012, Pages 97-102

  Ding, Cungang ^a   Ge, Qinghua ^a   Wang, Yemu ^a   Zhou, Zhen ^a   Zhi, Xiaojin ^a   Liu, Xiaofen ^a   Li, Zhou ^a  

^a National Pharmaceutical Engineering and Research Center   (China)

Author keywords

Chiral separation; Clevudine; D FMAU; Normal phase HPLC; Pharmacokinetics

Indexed keywords

CHIRAL SEPARATIONS; CLEVUDINE; D-FMAU; ELECTROSPRAY IONIZATION INTERFACE; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ENANTIOSELECTIVE; HUMAN PLASMAS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MOBILE PHASE; NORMAL PHASE HPLC;

ELECTROSPRAY IONIZATION; ENANTIOMERS; ETHANOL; HEXANE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMA (HUMAN);

CHIRALITY;

CLEVUDINE; ZIDOVUDINE;

ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SINGLE DRUG DOSE; VALIDATION STUDY;

ARABINOFURANOSYLURACIL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; LIMIT OF DETECTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

EID: 84862827972     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.12.020     Document Type: Article

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