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Volumn 12, Issue 2, 2012, Pages 162-169

Adjuvant chemotherapy, with or without postoperative radiotherapy, for resectable advanced pancreatic adenocarcinoma: Continue or stop?

Author keywords

Adjuvant therapy; Meta analysis; Pancreatic adenocarcinoma

Indexed keywords

CARBOPLATIN; CISPLATIN; DOXORUBICIN; FLUOROURACIL; FOLINIC ACID; GAMMA INTERFERON; GEMCITABINE; INTERLEUKIN 2; MITOMYCIN C; MITOXANTRONE; UFT;

EID: 84862827664     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2012.02.002     Document Type: Article
Times cited : (28)

References (33)
  • 1
    • 84872208504 scopus 로고    scopus 로고
    • International Agency for research on cancer, World Health Organization, [accessed 15.7.10]
    • International Agency for research on cancer, World Health Organization. Globocan. Web site. World Health Organization, http://globocan.iarc.fr/; 2008 [accessed 15.7.10].
    • (2008) Globocan. Web Site. World Health Organization
  • 2
    • 0038644769 scopus 로고    scopus 로고
    • Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-Year experience
    • DOI 10.1007/s00268-002-6659-z
    • Richter A, Niedergethmann M, Sturm JW, Lorenz D, Post S, Trede M. Long-term results of partial pancreaticoduodenectomy for ductal adenocarcinoma of the pancreatic head: 25-year experience. World J Surg 2003;27:324-9. (Pubitemid 36920145)
    • (2003) World Journal of Surgery , vol.27 , Issue.3 , pp. 324-329
    • Richter, A.1    Niedergethmann, M.2    Sturm, J.W.3    Lorenz, D.4    Post, S.5    Trede, M.6
  • 3
    • 14544270277 scopus 로고    scopus 로고
    • Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry
    • DOI 10.1136/gut.2004.047191
    • Carpelan-Holmström M, Nordling S, Pukkala E, Sankila R, Lüttges J, Klöppel G, et al. Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 2005;54: 385-7. (Pubitemid 40299095)
    • (2005) Gut , vol.54 , Issue.3 , pp. 385-387
    • Carpelan-Holmstrom, M.1    Nordling, S.2    Pukkala, E.3    Sankila, R.4    Luttges, J.5    Kloppel, G.6    Haglund, C.7
  • 4
  • 5
    • 0034329115 scopus 로고    scopus 로고
    • Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators
    • Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA, et al. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 2000;4:567-79.
    • (2000) J Gastrointest Surg , vol.4 , pp. 567-579
    • Sohn, T.A.1    Yeo, C.J.2    Cameron, J.L.3    Koniaris, L.4    Kaushal, S.5    Abrams, R.A.6
  • 6
    • 0021867923 scopus 로고
    • Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection
    • Kalser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 1985;120:899-903. (Pubitemid 15040883)
    • (1985) Archives of Surgery , vol.120 , Issue.8 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 8
    • 0031960736 scopus 로고    scopus 로고
    • Pancreatic resection for pancreatic carcinoma combined with neo- and adjuvant locoregional targeting immuno-chemotherapy - A prospective randomized study
    • Lygidakis NJ, Spentzouris N, Theodoracopoulos M, Dedemadi G, Gemos K, Kyriakou A. Pancreatic resection for pancreatic carcinoma combined with neoand adjuvant locoregional targeting immuno-chemotherapyea prospective randomized study. Hepatogastroenterology 1998;45:396-403. (Pubitemid 28167657)
    • (1998) Hepato-Gastroenterology , vol.45 , Issue.20 , pp. 396-403
    • Lygidakis, N.J.1    Spentzouris, N.2    Theodoracopoulos, M.3    Dedemadi, G.4    Gemos, K.5    Kyriakou, A.6
  • 9
    • 40749117229 scopus 로고    scopus 로고
    • Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 in patients with resected pancreatic cancer: Japan Adjuvant Study Group of Pancreatic Cancer (JASPAC-01)
    • DOI 10.1093/jjco/hym178
    • Maeda A, Boku N, Fukutomi A, Kondo S, Kinoshita T, Nagino M, et al. Randomized phase III trial of adjuvant chemotherapy with gemcitabine versus S-1 in patients with resected pancreatic cancer: Japan Adjuvant Study Group of Pancreatic Cancer (JASPAC-01). Jpn J Clin Oncol 2008;38:227-9. (Pubitemid 351419748)
    • (2008) Japanese Journal of Clinical Oncology , vol.38 , Issue.3 , pp. 227-229
    • Maeda, A.1    Boku, N.2    Fukutomi, A.3    Kondo, S.4    Kinoshita, T.5    Nagino, M.6    Uesaka, K.7
  • 10
    • 67649295454 scopus 로고    scopus 로고
    • A randomized multicentre phase II trial comparing adjuvant therapy in patients with interferon alpha-2b and 5-FU alone or in combination with either external radiation treatment and cisplatin (CapRI) or radiation alone regarding eventfree survival - CapRI-2
    • Märten A, Schmidt J, Ose J, Harig S, Abel U, Münter MW, et al. A randomized multicentre phase II trial comparing adjuvant therapy in patients with interferon alpha-2b and 5-FU alone or in combination with either external radiation treatment and cisplatin (CapRI) or radiation alone regarding eventfree survival - CapRI-2. BMC Cancer 2009;9:160.
    • (2009) BMC Cancer , vol.9 , pp. 160
    • Märten, A.1    Schmidt, J.2    Ose, J.3    Harig, S.4    Abel, U.5    Münter, M.W.6
  • 13
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: A randomized controlled trial
    • Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010;304:1073-81.
    • (2010) JAMA , vol.304 , pp. 1073-1081
    • Neoptolemos, J.P.1    Stocken, D.D.2    Bassi, C.3    Ghaneh, P.4    Cunningham, D.5    Goldstein, D.6
  • 14
    • 55549116683 scopus 로고    scopus 로고
    • A randomized phase II trial of adjuvant chemotherapy with uracil/tegafur and gemcitabine versus gemcitabine alone in patients with resected pancreatic cancer
    • Yoshitomi H, Togawa A, Kimura F, Ito H, Shimizu H, Yoshidome H, et al. A randomized phase II trial of adjuvant chemotherapy with uracil/tegafur and gemcitabine versus gemcitabine alone in patients with resected pancreatic cancer. Cancer 2008;113:2448-56.
    • (2008) Cancer , vol.113 , pp. 2448-2456
    • Yoshitomi, H.1    Togawa, A.2    Kimura, F.3    Ito, H.4    Shimizu, H.5    Yoshidome, H.6
  • 15
    • 70249099504 scopus 로고    scopus 로고
    • A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer
    • Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer
    • Ueno H, Kosuge T, Matsuyama Y, Yamamoto J, Nakao A, Egawa S, et al. A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer. Br J Cancer 2009;101:908-15.
    • (2009) Br J Cancer , vol.101 , pp. 908-915
    • Ueno, H.1    Kosuge, T.2    Matsuyama, Y.3    Yamamoto, J.4    Nakao, A.5    Egawa, S.6
  • 16
    • 33645858256 scopus 로고    scopus 로고
    • A multicenter randomized controlled trial to evaluate the effect of adjuvant cisplatin and 5-fluorouracil therapy after curative resection in cases of pancreatic cancer
    • Kosuge T, Kiuchi T, Mukai K, Kakizoe T. A multicenter randomized controlled trial to evaluate the effect of adjuvant cisplatin and 5-fluorouracil therapy after curative resection in cases of pancreatic cancer. Jpn J Clin Oncol 2006;36: 159-65.
    • (2006) Jpn J Clin Oncol , vol.36 , pp. 159-165
    • Kosuge, T.1    Kiuchi, T.2    Mukai, K.3    Kakizoe, T.4
  • 17
    • 0031826424 scopus 로고    scopus 로고
    • Adjuvant regional chemotherapy in advanced pancreatic cancer: Results of a prospective study
    • Beger HG, Link KH, Gansauge F. Adjuvant regional chemotherapy in advanced pancreatic cancer: results of a prospective study. Hepatogastroenterology 1998;45:638-43. (Pubitemid 28321033)
    • (1998) Hepato-Gastroenterology , vol.45 , Issue.21 , pp. 638-643
    • Beger, H.G.1    Link, K.H.2    Gansauge, F.3
  • 18
    • 0027461223 scopus 로고
    • Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater - Results of a controlled, prospective, randomised multicentre study
    • Bakkevold KE, Arnesjo B, Dahl O, Kambestad B, et al. Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vatereresults of a controlled, prospective, randomised multicentre study. Eur J Cancer 1993;29A:698-703. (Pubitemid 23077048)
    • (1993) European Journal of Cancer Part A: General Topics , vol.29 , Issue.5 , pp. 698-703
    • Bakkevold, K.E.1    Arnesjo, B.2    Dahl, O.3    Kambestad, B.4
  • 19
    • 0036895262 scopus 로고    scopus 로고
    • Regional targeting chemoimmunotherapy in patients undergoing pancreatic resection in an advanced stage of their disease: A prospective randomized study
    • DOI 10.1097/00000658-200212000-00013
    • Lygidakis NJ, Sgourakis G, Georgia D, Vlachos L, Raptis S. Regional targeting chemoimmunotherapy in patients undergoing pancreatic resection in an advanced stage of their disease: a prospective randomized study. Ann Surg 2002;236:806-13. (Pubitemid 35403236)
    • (2002) Annals of Surgery , vol.236 , Issue.6 , pp. 806-813
    • Lygidakis, N.J.1    Sgourakis, G.2    Georgia, D.3    Vlachos, L.4    Raptis, S.5
  • 20
  • 21
    • 0029929798 scopus 로고    scopus 로고
    • Adjuvant therapy following pancreatic resection for pancreatic duct carcinoma: A prospective randomized study
    • Lygidakis NJ, Stringaris K. Adjuvant therapy following pancreatic resection for pancreatic duct carcinoma: a prospective randomized study. Hepatogastroenterology 1996;43:671-80. (Pubitemid 26191295)
    • (1996) Hepato-Gastroenterology , vol.43 , Issue.9 , pp. 671-680
    • Lygidakis, N.J.1    Stringaris, K.2
  • 22
    • 78049434513 scopus 로고    scopus 로고
    • Adjuvant gemcitabine alone versus gemcitabine-based chemoradiotherapy after curative resection for pancreatic cancer: A randomized EORTC-40013- 22012/FFCD-9203/GERCOR phase II study
    • Van Laethem JL, Hammel P, Mornex F, Azria D, Van Tienhoven G, Vergauwe P, et al. Adjuvant gemcitabine alone versus gemcitabine-based chemoradiotherapy after curative resection for pancreatic cancer: a randomized EORTC-40013- 22012/FFCD-9203/GERCOR phase II study. J Clin Oncol 2010;28:4450-6.
    • (2010) J Clin Oncol , vol.28 , pp. 4450-4456
    • Van Laethem, J.L.1    Hammel, P.2    Mornex, F.3    Azria, D.4    Van Tienhoven, G.5    Vergauwe, P.6
  • 25
    • 58149393693 scopus 로고    scopus 로고
    • Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: A prospective randomized controlled trial
    • Morak MJ, van der Gaast A, Incrocci L, van Dekken H, Hermans JJ, Jeekel J, et al. Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. Ann Surg 2008;248:1031-41.
    • (2008) Ann Surg , vol.248 , pp. 1031-1041
    • Morak, M.J.1    Van Der Gaast, A.2    Incrocci, L.3    Van Dekken, H.4    Hermans, J.J.5    Jeekel, J.6
  • 26
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: Phase III trial of the EORTC gastrointestinal tract cancer cooperative group
    • discussion 782-774
    • Klinkenbijl JH, Jeekel J, Sahmoud T, van Pel R, Couvreur ML, Veenhof CH, et al. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 1999;230:776-82. discussion 782-774.
    • (1999) Ann Surg , vol.230 , pp. 776-782
    • Klinkenbijl, J.H.1    Jeekel, J.2    Sahmoud, T.3    Van Pel, R.4    Couvreur, M.L.5    Veenhof, C.H.6
  • 27
    • 0032985541 scopus 로고    scopus 로고
    • Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database
    • DOI 10.1016/S1072-7515(99)00075-7, PII S1072751599000757
    • Sener SF, Fremgen A, Menck HR, Winchester DP. Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985- 1995, using the National Cancer Database. J Am Coll Surg 1999;189:1-7. (Pubitemid 29307735)
    • (1999) Journal of the American College of Surgeons , vol.189 , Issue.1 , pp. 1-7
    • Sener, S.F.1    Fremgen, A.2    Menck, H.R.3    Winchester, D.P.4
  • 30
    • 58149383101 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: Results of a prospective phase II trial
    • Heinrich S, Schafer M, Weber A, Hany TF, Bhure U, Pestalozzi BC, et al. Neoadjuvant chemotherapy generates a significant tumor response in resectable pancreatic cancer without increasing morbidity: results of a prospective phase II trial. Ann Surg 2008;248:1014-22.
    • (2008) Ann Surg , vol.248 , pp. 1014-1022
    • Heinrich, S.1    Schafer, M.2    Weber, A.3    Hany, T.F.4    Bhure, U.5    Pestalozzi, B.C.6
  • 31
    • 45149091560 scopus 로고    scopus 로고
    • Prospective phase II trial on neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head
    • Heinrich S, Pestalozzi B, Schafer M, Weber A, Bauerfeind P, Knuth A, et al. Prospective phase II trial on neoadjuvant chemotherapy with gemcitabine and cisplatin for resectable adenocarcinoma of the pancreatic head. J Clin Oncol 2008;26:2526-31.
    • (2008) J Clin Oncol , vol.26 , pp. 2526-2531
    • Heinrich, S.1    Pestalozzi, B.2    Schafer, M.3    Weber, A.4    Bauerfeind, P.5    Knuth, A.6
  • 32
    • 80052293264 scopus 로고    scopus 로고
    • Neoadjuvant therapy in pancreatic adenocarcinoma: A meta-analysis of phase II trials
    • Assifi MM, Lu X, Eibl G, Reber HA, Li G, Hines OJ. Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials. Surgery 2011;150:466-73.
    • (2011) Surgery , vol.150 , pp. 466-473
    • Assifi, M.M.1    Lu, X.2    Eibl, G.3    Reber, H.A.4    Li, G.5    Hines, O.J.6
  • 33
    • 81155158875 scopus 로고    scopus 로고
    • Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: A randomized multicenter phase III study (NEOPAC study)
    • Heinrich S, Pestalozzi B, Lesurtel M, Berrevoet F, Laurent S, Delpero JR, et al. Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: a randomized multicenter phase III study (NEOPAC study). BMC Cancer 2011;11:346.
    • (2011) BMC Cancer , vol.11 , pp. 346
    • Heinrich, S.1    Pestalozzi, B.2    Lesurtel, M.3    Berrevoet, F.4    Laurent, S.5    Delpero, J.R.6


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