The effects of ketorolac on microvascular thrombosis in lower extremity reconstruction

Plastic and Reconstructive Surgery

Volumn 129, Issue 6, 2012, Pages 1322-1327

  Lee, Kyeong Tae ^a   Jeon, Byung Joon ^a   Lim, So Young ^a   Pyon, Jai Kyung ^a   Bang, Sa Ik ^a   Oh, Kap Sung ^a   Mun, Goo Hyun ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

KETOROLAC; PROSTAGLANDIN SYNTHASE INHIBITOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; FOLLOW UP; FREE TISSUE GRAFT; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEG; MALE; METHODOLOGY; MICROCIRCULATION; MICROSURGERY; MIDDLE AGED; PAIN ASSESSMENT; PLASTIC SURGERY; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; RETROSPECTIVE STUDY; THROMBOSIS; TREATMENT OUTCOME; VASCULARIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CYCLOOXYGENASE INHIBITORS; FEMALE; FOLLOW-UP STUDIES; FREE TISSUE FLAPS; HUMANS; INJECTIONS, INTRAVENOUS; KETOROLAC; LOWER EXTREMITY; MALE; MICROCIRCULATION; MICROSURGERY; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POSTOPERATIVE CARE; RECONSTRUCTIVE SURGICAL PROCEDURES; RETROSPECTIVE STUDIES; THROMBOSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84862825061     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e31824ec33f     Document Type: Review

References (28)

1. Hidalgo DA, Disa JJ, Cordeiro PG, Hu QY. A review of 716 consecutive free flaps for oncologic surgical defects: Refine-ment in donor-site selection and technique. Plast Reconstr Surg. 1998;102:722-732.
2. Khouri RK, Cooley BC, Kunselman AR, et al. A prospective study of microvascular free-flap surgery and outcome. Plast Reconstr Surg. 1998;102:711-721.
3. Basheer MH, Wilson SM, Lewis H, Herbert K. Microvascular free tissue transfer in reconstruction of the lower limb. J Plast Reconstr Aesthet Surg. 2008;61:525-528.
4. Conrad MH, Adams WP Jr. Pharmacologic optimization of microsurgery in the new millennium. Plast Reconstr Surg. 2001;108:2088-2096.
5. Davies DM. A world survey of anticoagulation practice in clinical microvascular surgery. Br J Plast Surg. 1982;35:96-99.
6. Macdonald DJ. Anaesthesia for microvascular surgery: A physiological approach. Br J Anaesth. 1985;57:904-912.
7. Shufflebarger JV, Doyle J, Roth T, Maguire K, Rothkopf DM. The effect of ketorolac on microvascular thrombosis in an experimental rabbit model. Plast Reconstr Surg. 1996;98:140-145.
8. Buckley RC, Davidson SF, Das SK. Effects of ketorolac tromethamine (Toradol) on a functional model of microvascular thrombosis. Br J Plast Surg. 1993;46:296-299.
9. Kroll SS, Schusterman MA, Reece GP, et al. Timing of pedicle thrombosis and flap loss after free-tissue transfer. Plast Reconstr Surg. 1996;98:1230-1233.
10. Herold C, Gohritz A, Meyer-Marcotty M, et al. Is there an association between comorbidities and the outcome of microvascular free tissue transfer? J Reconstr Microsurg. 2011;27:127-132.
11. Nahabedian MY, Momen B, Manson PN. Factors associated with anastomotic failure after microvascular reconstruction of the breast. Plast Reconstr Surg. 2004;114:74-82.
12. Cooley BC, Hanel DP, Anderson RB, Foster MD, Gould JS. The influence of diabetes on free flap transfer: I. Flap survival and microvascular healing. Ann Plast Surg. 1992;29:58-64.
13. Buckley MM, Brogden RN. Ketorolac: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs 1990;39:86-109.
14. Conrad KA, Fagan TC, Mackie MJ, Mayshar PV. Effects of ketorolac tromethamine on hemostasis in volunteers. Clin Pharmacol Ther. 1988;43:542-546.
15. Concannon MJ, Meng L, Welsh CF, Puckett CL. Inhibition of perioperative platelet aggregation using toradol (ketorolac). Ann Plast Surg. 1993;30:264-266.
16. Messina EJ, Weiner R, Kaley G. Microcirculatory effects of prostaglandins E1, E2, and A1 in the rat mesentery and cremaster muscle. Microvasc Res. 1974;8:77-89.
17. Rodriguez Vegas JM, Ruiz Alonso ME, Teran Saavedra PP. PGE-1 in replantation and free tissue transfer: Early preliminary experience. Microsurgery 2007;27:395-397.
18. Ashjian P, Chen CM, Pusic A, Disa JJ, Cordeiro PG, Mehrara BJ. The effect of postoperative anticoagulation on microvascular thrombosis. Ann Plast Surg. 2007;59:36-39.
19. Sharma S, Chang DW, Koutz C, et al. Incidence of hematoma associated with ketorolac after TRAM flap breast reconstruction. Plast Reconstr Surg. 2001;107:352-355.
20. Chin CJ, Franklin JH, Turner B, Sowerby L, Fung K, Yoo JH. Ketorolac in thyroid surgery: Quantifying the risk of hematoma. J Otolaryngol Head Neck Surg. 2011;40:196-199.
21. Chin KR, Sundram H, Marcotte P. Bleeding risk with ketorolac after lumbar microdiscectomy. J Spinal Disord Tech. 2007;20:123-126.
22. McQuay HJ, Poppleton P, Carroll D, Summerfield RJ, Bullingham RE, Moore RA. Ketorolac and acetaminophen for orthopedic postoperative pain. Clin Pharmacol Ther. 1986; 39:89-93.
23. Bloomfield SS, Mitchell J, Cissell GB, Barden TP, Yee JP. Ketorolac versus aspirin for postpartum uterine pain. Pharmacotherapy 1986;6:247-252.
24. Syntex Laboratories, I. Toradol IM (ketorolac tromethamine) prescribing information. Palo Alto, Calif.; 1990.
25. Syntex Laboratories, I. Toradol product monograph. Palo Alto, Calif.; 1990.
26. Jallad NS, Garg DC, Martinez JJ, Mroszczak EJ, Weidler DJ. Pharmacokinetics of single-dose oral and intramuscular ketorolac tromethamine in the young and elderly. J Clin Pharmacol. 1990;30:76-81.
27. Gillies GW, Kenny GN, Bullingham RE, McArdle CS. The morphine sparing effect of ketorolac tromethamine: A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery. Anaesthesia 1987;42:727-731.
28. Spowart K, Greer IA, McLaren M, Lloyd J, Bullingham RE, Forbes CD. Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. Thromb Haemost. 1988;60:382-386.