Synthesis of 3-trifluoromethyl-1,4-dihydropyridazines by the PTSA-catalyzed reaction of α,β-unsaturated aldehydes with (E)-1-phenyl-2-(2,2,2- trifluoroethylidene)

Synlett

Volumn 23, Issue 6, 2012, Pages 935-937

  Xie, Haibo ^a   Zhu, Jiangtao ^a   Chen, Zixian ^a   Li, Shan ^a   Wu, Yongming ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

3,3 sigmatropic rearrangement; electro cyclic rearrangement; heterocycles; hydrazine; pyridazine

Indexed keywords

1 PHENYL 2 (2,2,2 TRIFLUOROETHYLIDENE)HYDRAZINE; 3 TRIFLUOROMETHYL 1,4 DIHYDROPYRIDAZINE DERIVATIVE; 4 METHYL 1 PHENYL 3 (TRIFLUOROMETHYL) 1,4 DIHYDROPYRIDAZINE; ALDEHYDE DERIVATIVE; ALPHA BETA UNSATURATED ALDEHYDE DERIVATIVE; CADRALAZINE; EMORFAZONE; HYDRAZINE DERIVATIVE; LEVOSIMENDAN; PIMOBENDAN; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; PROCESS DEVELOPMENT;

EID: 84862823172     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0031-1290608     Document Type: Article

References (10)

1. Kolar P, Tiler M, In Advances in Heterocyclic Chemistry Vol. 75 Katritzky A R. Academic Press San Diego 2000 167
2. Brown D J., In Chemistry of Heterocyclic Compounds Vol. 57 Taylor E C. Wipf P Wiley New York 2000 1
3. Maes B U. W., Lemière G L. F., In Comprehensive Heterocyclic Chemistry 3rd ed., Vol. 8 Aitken A Elsevier Amsterdam 2008 1
4. Knorr L, Ber. Dtsch. Chem. Ges. 1885 299
5. Fischer E, Justus Liebigs Ann. Chem. 1886 147
6. Tauber E, Ber. Dtsch. Chem. Ges. 1895 451
7. Tiler M, Stanovnik B, Adv. Heterocycl. Chem. 1968 211
8. Hunston R N., Parrick J, Shaw C J. G., In Rodd's Chemistry of Carbon Compounds Vol. 4 Coffey S Elsevier Amsterdam 1989 1
9. Mathew T, Keller M, Hunkler D, Pinzbach H, Tetrahedron Lett. 1996 4491
10. Mathew T, Tonne J, Sedelmeier G, Grund C, Keller M, Hunkler D, Knothe L, Pinzbach H, Eur. J. Org. Chem. 2007 2133