Universal pleiotropy is not a valid null hypothesis: Reply to Hill and Zhang

Nature Reviews Genetics

Volumn 13, Issue 4, 2012, Pages 296-

  Wagner, Günter P ^a   Zhang, Jianzhi ^b  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPERIMENTAL DESIGN; GENE MUTATION; HUMAN; LETTER; MATHEMATICAL MODEL; NULL HYPOTHESIS; PLEIOTROPY; PRIORITY JOURNAL;

EID: 84862820678     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2949-c2     Document Type: Letter

References (4)

1. Wagner, G. P. & Zhang, J. The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nature Rev. Genet. 12, 204-213 (2011).
2. Hill, W. G. & Zhang, X.-S. Assessing pleiotropy and its evolutionary consequences: pleiotropy is not necessarily limited, nor need it hinder the evolution of complexity. Nature Rev. Genet. 21 Feb 2012 (doi:10.1038/nrg2949-c1) .
3. Fisher, R. A. The Genetic Theory of Natural Selection (Clarendon, Oxford, 1930).
4. Hill, W. G. & Zhang, X. S. On the pleiotropic structure of the genotype-phenotype map and the evolvability of complex organisms. Genetics 3 Jan 2012 (doi:10.1534/genetics.111.135681).