Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis

Biochemical Pharmacology

Volumn 83, Issue 7, 2012, Pages 866-873

  Saha, Sougata ^a,b   Wang, Junling ^a   Buckley, Brian ^c   Wang, Qingqing ^d   Lilly, Brenda ^d   Chernov, Mikhail ^c   Kashina, Anna ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b TEZPUR UNIVERSITY   (India)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

Angiogenesis; Arginylation; ATE1 inhibitors; Cell motility; tannic acid

Indexed keywords

ACYLTRANSFERASE INHIBITOR; ARGINYLTRANSFERASE; MERBROMIN; SURAMIN; TANNIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CELL ASSAY; CELL MOTILITY; CONTROLLED STUDY; HEART DISEASE; IN VIVO STUDY; MALE; MOLECULAR LIBRARY; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINOACYLTRANSFERASES; ANGIOGENESIS INHIBITORS; ANIMALS; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, KNOCKOUT; MOLECULAR STRUCTURE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; SMALL MOLECULE LIBRARIES; TRANSFECTION;

EID: 84862817369     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.01.012     Document Type: Article

References (32)

1. Y.T. Kwon, A.S. Kashina, I.V. Davydov, R.G. Hu, J.Y. An, and J.W. Seo An essential role of N-terminal arginylation in cardiovascular development Science 297 2002 96 99
2. C.C. Wong, T. Xu, R. Rai, A.O. Bailey, J.R. Yates 3rd, and Y.I. Wolf Global analysis of posttranslational protein arginylation PLoS Biol 5 2007 e258
3. M. Karakozova, M. Kozak, C.C. Wong, A.O. Bailey, J.R. Yates 3rd, and A. Mogilner Arginylation of beta-actin regulates actin cytoskeleton and cell motility Science 313 2006 192 196
4. S. Saha, M.M. Mundia, F. Zhang, R.W. Demers, F. Korobova, and T. Svitkina Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins Mol Biol Cell 21 2010 1350 1361
5. C.S. Brower, and A. Varshavsky Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations PLoS ONE 4 2009 e7757
6. G. Bongiovanni, G.D. Fidelio, H.S. Barra, and M.E. Hallak The post-translational incorporation of arginine into a beta-amyloid peptide increases the probability of alpha-helix formation Neuroreport 7 1995 326 328
7. M. Mutsuddi, C.M. Marshall, K.A. Benzow, M.D. Koob, and I. Rebay The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila Curr Biol 14 2004 302 308
8. A. Ciechanover, S. Ferber, D. Ganoth, S. Elias, A. Hershko, and S. Arfin Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway J Biol Chem 263 1988 11155 11167
9. J. Kopitz, B. Rist, and P. Bohley Post-translational arginylation of ornithine decarboxylase from rat hepatocytes Biochem J 267 1990 343 348
10. J. Li, and C.M. Pickart nactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: identification of residues proximal to the arsenoxide site Biochemistry 34 1995 39 47
11. M. Kato Heparin as an inhibitor of L-arginyl-tRNA: protein arginyltransferase J Biochem 94 1983 2015 2022
12. F. Yang, X. Xia, H.Y. Lei, and E.D. Wang Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity J Biol Chem 285 2010 39437 39446
13. M. Yu, G. Chakraborty, M. Grabow, and N.A. Ingoglia Serine protease inhibitors block N-terminal arginylation of proteins by inhibiting the arginylation of tRNA in rat brains Neurochem Res 19 1994 105 110
14. R.G. Hu, H. Wang, Z. Xia, and A. Varshavsky The N-end rule pathway is a sensor of heme Proc Natl Acad Sci USA 105 2008 76 81
15. J. Wang, X. Han, S. Saha, T. Xu, R. Rai, and F. Zhang Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo Chem Biol 18 2011 121 130
16. R. Rai, and A. Kashina Identification of mammalian arginyltransferases that modify a specific subset of protein substrates Proc Natl Acad Sci USA 102 2005 10123 10128
17. H. Liu, B. Chen, and B. Lilly Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1 Angiogenesis 11 2008 223 234
18. S. Elias, and A. Ciechanover Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase J Biol Chem 265 1990 15511 15517
19. A. Bachmair, D. Finley, and A. Varshavsky In vivo half-life of a protein is a function of its amino-terminal residue Science 234 1986 179 186
20. I.V. Davydov, and A. Varshavsky RGS4 is arginylated and degraded by the N-end rule pathway in vitro J Biol Chem 275 2000 22931 22941
21. M.J. Lee, T. Tasaki, K. Moroi, J.Y. An, S. Kimura, and I.V. Davydov RGS4 and RGS5 are in vivo substrates of the N-end rule pathway Proc Natl Acad Sci USA 102 2005 15030 15035
22. S. Kurosaka, N.A. Leu, F. Zhang, R. Bunte, S. Saha, and J. Wang Arginylation-dependent neural crest cell migration is essential for mouse development PLoS Genet 6 2010 e1000878
23. H. Kamei, T. Koide, Y. Hashimoto, T. Kojima, and M. Hasegawa Tumor cell growth suppression by tannic acid Cancer Biother Radiopharm 14 1999 135 138
24. X. Liu, J.K. Kim, Y. Li, J. Li, F. Liu, and X. Chen Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells J Nutr 135 2005 165 171
25. E. Trabucchi, F. Preis Baruffaldi, C. Baratti, and W. Montorsi Topical treatment of experimental skin lesions in rats: macroscopic, microscopic and scanning electron-microscopic evaluation of the healing process Int J Tissue React 8 1986 533 544
26. H. Uneyama, C. Uneyama, S. Ebihara, and N. Akaike Suramin and reactive blue 2 are antagonists for a newly identified purinoceptor on rat megakaryocyte Br J Pharmacol 111 1994 245 249
27. W.R. Rice, and F.M. Singleton Reactive blue 2 selectively inhibits P2y-purinoceptor-stimulated surfactant phospholipid secretion from rat isolated alveolar type II cells Br J Pharmacol 97 1989 158 162
28. S. Baghdiguian, J.L. Boudier, J.A. Boudier, and J. Fantini Intracellular localisation of suramin, an anticancer drug, in human colon adenocarcinoma cells: a study by quantitative autoradiography Eur J Cancer 32A 1996 525 532
29. L. Lamalice, F. Le Boeuf, and J. Huot Endothelial cell migration during angiogenesis Circ Res 100 2007 782 794
30. A.R. Albig, and W.P. Schiemann Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling Mol Biol Cell 16 2005 609 625
31. Y. Jin, X. An, Z. Ye, B. Cully, J. Wu, and J. Li RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells J Biol Chem 284 2009 23436 23443
32. X. Chen, J.A. Beutler, T.G. McCloud, A. Loehfelm, L. Yang, and H.F. Dong Tannic acid is an inhibitor of CXCL12 (SDF-1alpha)/CXCR4 with antiangiogenic activity Clin Cancer Res 9 2003 3115 3123