A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan

Laryngoscope

Volumn 122, Issue 4, 2012, Pages 925-929

  Ahmed, Wael A ^a,b   Tsutsumi, Makiko ^a   Nakata, Seiichi ^a   Mori, Terumi ^a   Nishimura, Yoichi ^a   Fujisawa, Toshiyuki ^a   Kato, Ichiro ^a   Nakashima, Mayuki ^a   Kurahashi, Hiroki ^a   Suzuki, Kenji ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

^b SOHAG UNIVERSITY   (Egypt)

Author keywords

functional variation; genes; hypocretin neuropeptide precursor gene; Level of Evidence: 2b; Obstructive sleep apnea syndrome; reporter gene assay

Indexed keywords

GENOMIC DNA; HYPOCRETIN NEUROPEPTIDE PRECURSOR; LUCIFERASE; OREXIN A; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HELA CELL; HUMAN; HUMAN CELL; INTRON; JAPAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REPORTER GENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP APNEA SYNDROME;

ALLELES; DNA; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HUMANS; INCIDENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JAPAN; MALE; MIDDLE AGED; NEUROPEPTIDES; POLYMERASE CHAIN REACTION; SLEEP APNEA, OBSTRUCTIVE; SLEEP, REM;

EID: 84862815787     PISSN: 0023852X     EISSN: 15314995     Source Type: Journal    
DOI: 10.1002/lary.23179     Document Type: Article

References (23)

1. Guilleminault C, Tilkian A, Dement WC,. The sleep apnea syndromes. Annu Rev Med 1976; 27: 465-484.
2. Sleep related breathing disorders in adults: recommendation for syndrome definition and measurement techniques in clinical research. Report of an American Academy of Sleep Medicine Task Force. Sleep 1999; 22: 667-689.
3. Punjabi NM,. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc 2008; 5: 136-143.
4. Punjabi NM, Sorkin JD, Katzel LI, Golberg AP, Schwartz AR, Smith PL,. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 2002; 165: 677-682.
5. Leung RS, Bradley TD,. Sleep apnea and cardiovascular disease. Am J Respir Crit Care Med 2001; 164: 2147-2165.
6. Redline S, Tosteson T, Tishler PV, Carskadon MA, Millman RP,. Studies in the genetics of obstructive sleep apnea: familial aggregation of symptoms associated with sleep related breathing disturbances. Am Rev Respir Dis 1992: 145 (2 pt 1): 440-444.
7. Palmer LJ, Buxbaum SG, Larkin E, et al. A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet 2003; 72: 340-350.
8. Pillar G, Lavie P,. Assessment the role of inheritance in sleep apnea syndrome. Am J Respir Crit Care Med 1995; 151 (3 pt 1): 688-691.
9. Redline SR, Tishler PV,. The genetics of sleep apnea. Sleep Med Rev 2000; 4: 583-602.
10. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-585.
11. De Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998; 95: 322-327.
12. Nishino S,. The hypocretin/orexin system in health and disease. Biol Psychiatry 2003; 54: 87-95.
13. Siegel JM,. Hypocretin (orexin): role in animal behavior and neuropathology. Annu Rev Psychol 2004; 55: 125-148.
14. Busquets X, Barbe F, Barcelo A, et al. Decreased plasma levels of orexin-A in sleep apnea. Respiration 2004; 71: 575-579.
15. Sakurai S, Nishijima T, Takahashi S, Yamauchi K, Arihara Z, Takahashi K,. Clinical significance of daytime plasma orexin-A-like immunoreactivity in patients with obstructive sleep apnea hypopnea syndrome. Respiration 2004; 71: 380-384.
16. Aksu K, Guven Firat S, Aksu F, et al. Obstructive sleep apnoea, cigarette smoking and plasma orexin-A in a sleep clinic cohort. J Int Med Res 2009; 37: 331-340.
17. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP,. Using the Berlin Questionnaire to identify patients at risk for sleep apnea syndrome. Ann Intern Med 1999; 131: 485-491.
18. Williams RH, Burdakov D,. Hypothalamic orexins/hypocretins as regulators of breathing. Expert Rev Mol Med 2008; 10: e28.
19. Sakurai S, Nishijima T, Takahashi S, Yamauchi K, Arihara Z, Takahashi K,. Low plasma orexin-A levels were improved by continuous positive airway pressure treatment in patients with severe obstructive sleep apnea-hypopnea syndrome. Chest 2005; 127: 731-737.
20. Merika M, Orkin SH,. DNA-binding specificity of GATA family transcription factors. Mol Cell Biol 1993; 13: 3999-4010.
21. Mitsuma T, Hirooka Y, Kayama M, et al. Radioimmunoassay for orexin-A. Life Sci 2000; 66: 897-904.
22. Taheri S, Mahmoodi M, Opacka-Juffry J, Ghatei MA, Bloom SR,. Distribution and quantification of immunoreactive orexin-A in rat tissues. FEBS Lett 1999; 457: 157-161.
23. Nishijima T, Sakurai S, Arihara Z, Takahashi K,. Plasma orexin-A like immunoreactivity concentrations in patients with sleep apnea hypopnea syndrome. Peptides 2003; 24: 407-411.